1 Barnes, KC, Grant, AV, Hansel, NN, et al. (2007) African Americans with asthma: genetic insights. Proc Am Thorac Soc 4, 58–68.
2 Olshansky, SJ, Passaro, DJ, Hershow, RC, et al. (2005) A potential decline in life expectancy in the United States in the 21st century. N Engl J Med 352, 1138–1145.
3 Vaidya, D, Szklo, M, Ding, J, et al. (2007) Agreement of two metabolic syndrome definitions and their association with subclinical atherosclerosis: multi-ethnic study of atherosclerosis cross sectional study. Metab Syndr Relat Disord 5, 343–352.
4 Burns, SF, Lee, SJ & Arslanian, SA (2009) In vivo insulin sensitivity and lipoprotein particle size and concentration in black and white children. Diabetes Care 32, 2087–2093.
5 Bjorksten, B, Clayton, T, Ellwood, P, et al. (2008) Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol 19, 110–124.
6 Khera, A, McGuire, DK, Murphy, SA, et al. (2005) Race and gender differences in C-reactive protein levels. J Am Coll Cardiol 46, 464–469.
7 Albert, MA, Glynn, RJ, Buring, J, et al. (2004) C-reactive protein levels among women of various ethnic groups living in the United States (from the Women's Health Study). Am J Cardiol 93, 1238–1242.
8 Cordain, L, Eaton, SB, Sebastian, A, et al. (2005) Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 81, 341–354.
9 Flinn, MV, Geary, DC & Ward, CV (2005) Ecological dominance, social competition, and coalitionary arms races: why humans evolved extraordinary intelligence. Evol Hum Behav 26, 10–46.
10 Innis, SM (2003) Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. J Pediatr 143, Suppl. 4, S1–S8.
11 Innis, SM (2008) Dietary omega 3 fatty acids and the developing brain. Brain Res 1237, 35–43.
12 Guillou, H, Zadravec, D, Martin, PGP, et al. (2010) The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice. Prog Lipid Res 49, 186–199.
13 Blasbalg, TL, Hibbeln, JR, Ramsden, CE, et al. (2011) Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr 93, 950–962.
14 Schmitz, G & Ecker, J (2008) The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 47, 147–155.
15 Simopoulos, AP (2008) The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exper Biol Med 233, 674–688.
16 Torrejon, C, Jung, UJ & Deckelbaum, RJ (2007) n-3 Fatty acids and cardiovascular disease: actions and molecular mechanisms. Prostaglandins Leukot Essent Fatty Acids 77, 319–326.
17 Novak, TE, Babcock, TA, Jho, DH, et al. (2003) NF-κB inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-α transcription. Am J Physiol Lung Cell Mol Physiol 284, L84–L89.
18 Soberman, RJ & Christmas, P (2003) The organization and consequences of eicosanoid signaling. J Clin Invest 111, 1107–1113.
19 Jump, DB & Clarke, SD (1999) Regulation of gene expression by dietary fat. Ann Rev Nutr 19, 63–90.
20 Xu, J, Nakamura, MT, Cho, HP, et al. (1999) Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. J Biol Chem 274, 23577–23583.
21 Worgall, TS, Sturley, SL, Seo, T, et al. (1998) Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. J Biol Chem 273, 25537–25540.
22 Ghosh, S & Karin, M (2002) Missing pieces in the NF-κB puzzle. Cell 109, S81–S96.
23 Muskiet, FAJ (2010) Pathophysiology and evolutionary aspects of dietary fats and long-chain polyunsaturated fatty acids across the life cycle. In Fat Detection: Taste, Texture, and Post Ingestive Effects [Montmayeur, JP and le Coutre, J, editors]. Boca Raton, FL: CRC Press. http://www.ncbi.nlm.nih.gov/books/NBK53557/.
24 Hussein, N, Ah-Sing, E, Wilkinson, P, et al. (2005) Long-chain conversion of [13C]linoleic acid and α-linolenic acid in response to marked changes in their dietary intake in men. J Lipid Res 46, 269–280.
25 Vlaardingerbroek, H, Hornstra, G, de Koning, TJ, et al. (2006) Essential polyunsaturated fatty acids in plasma and erythrocytes of children with inborn errors of amino acid metabolism. Mol Genet Metab 88, 159–165.
26 Harris, WS, Mozaffarian, D, Rimm, E, et al. (2009) Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation 119, 902–907.
27 Friesen, RW & Innis, SM (2010) Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. Am J Clin Nutr 91, 23–31.
28 Malerba, G, Schaeffer, L, Xumerle, L, et al. (2008) SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease. Lipids 43, 289–299.
29 Xie, L & Innis, SM (2008) Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J Nutr 138, 2222–2228.
30 Schaeffer, L, Gohlke, H, Muller, M, et al. (2006) Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 15, 1745–1756.
31 Martinelli, N, Girelli, D, Malerba, G, et al. (2008) FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am J Clin Nutr 88, 941–949.
32 Rzehak, P, Heinrich, J, Klopp, N, et al. (2009) Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. Br J Nutr 101, 20–26.
33 Bowden, DW, Lehtinen, AB, Ziegler, JT, et al. (2008) Genetic epidemiology of subclinical cardiovascular disease in the Diabetes Heart Study. Ann Hum Genet 72, 598–610.
34 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP). JAMA 285, 2486–2497.
35 Metcalfe, LD, Schmitz, AA & Pelka, JR (1966) Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis. Anal Chem 38, 514–515.
36 Weaver, KL, Ivester, P, Seeds, MC, et al. (2009) Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem 284, 15400–15407.
37 Tanaka, T, Shen, J, Abecasis, GR, et al. (2009) Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI study. PLoS Genet 5, e1000338.
38 Allayee, H, Baylin, A, Hartiala, J, et al. (2008) Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. Am J Clin Nutr 88, 934–940.
39 Buetow, KH, Edmonson, M, MacDonald, R, et al. (2001) High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci U S A 98, 581–584.
40 Barrett, JC, Fry, B, Maller, J, et al. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263–265.
41 Gabriel, SB, Schaffner, SF, Nguyen, H, et al. (2002) The structure of haplotype blocks in the human genome. Science 296, 2225–2229.
42 Almasy, L & Blangero, J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62, 1198–1211.
43 Lattka, E, Illig, T, Heinrich, J, et al. (2009) FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases. J Nutrigenet Nutrigenomics 2, 119–128.
47 Horrobin, DF, Ells, K, Morse-Fisher, N, et al. (1991) Fatty acid distribution in plasma phospholipids in normal individuals from different geographical locations. J Nutr Environ Med 2, 249–258.
48 Mathias, RA, Sergeant, S, Ruczinski, I, et al. (2011) The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet 12, 50.
49 Haldane, JBS (1949) The rate of mutation of human genes. Proc Eighth Int Congr Genet Hered 35, 267–273.
50 Luca, F, Perry, GH & Di Rienzo, A (2010) Evolutionary adaptations to dietary changes. Ann Rev Nutr 30, 291–314.
51 Ramsden, CE, Hibbeln, JR, Majchrzak, SF, et al. (2010) n-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr 104, 1586–1600.