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Dietary magnesium intake can affect mechanical properties of rat carotid artery

Published online by Cambridge University Press:  09 March 2007

Pascal Laurant ,
Daniel Hayoz ,
Hans Brunner  and
Alain Berthelot
Pascal Laurant*
Affiliation:
Laboratoire Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Place St-Jacques, 25030 Besançon Cedex, France
Daniel Hayoz
Affiliation:
Division of Hypertension, CHUV, 1011 Lausanne, Switzerland
Hans Brunner
Affiliation:
Division of Hypertension, CHUV, 1011 Lausanne, Switzerland
Alain Berthelot
Affiliation:
Laboratoire Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Place St-Jacques, 25030 Besançon Cedex, France
*
*Corresponding author: Pascal Laurant, fax +333 81 66 56 91, email pascal.laurant@univ-fcomte.fr
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Abstract

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The purpose of the present study was to determine the effects of Mg deficiency and supplementation on the mechanical properties of the rat common carotid artery. The internal diameter and intra-arterial pressure of carotid artery were measured continuously using an echo-tracking device. Systolic, diastolic and mean intra-arterial pressures were not significantly different in Mg-deficient, -supplemented or control rats. Histological examination showed a larger cross-sectional area, increased intima-media thickness and a greater media:lumen value in carotid artery of Mg-deficient rats, indicating that Mg deficiency may directly stimulate growth and/or proliferation of arterial wall components. In addition, we observed a negative linear relationship between intima-media thickness and plasma Mg concentration, suggesting that increased Mg intake may counteract arterial wall hypertrophy. Neither Mg deficiency nor supplementation modified the arterial distensibility v. intra-arterial pressure curve or the Eincv. wall stress curve, indicating that dietary Mg intake did not modify wall stiffness in young rats. At mean intra-arterial pressure, the stress and Einc values were, however, significantly lower in Mg-deficient rats (P<0·05 in both cases); this finding could be related to the alteration in the geometry of the carotid artery. In conclusion, these findings suggest that Mg deficiency modifies the mechanical properties of the common carotid artery in young rats. Since Mg deficiency is considered a risk factor, these mechanical alterations could contribute to the development of atherosclerosis, hypertension and cardiovascular diseases.

Keywords

Magnesium intakeEcho trackingWall thicknessCalcium
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 5 , November 2000 , pp. 757 - 764
Copyright
Copyright © The Nutrition Society 2000

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