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Dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in children – a workshop report

  • Berthold Koletzko (a1), Ricardo Uauy (a2) (a3), Andreu Palou (a4) (a5), Frans Kok (a6), Gerard Hornstra (a7), Ans Eilander (a8), Diego Moretti (a8), Saskia Osendarp (a8), Peter Zock (a8) and Sheila Innis (a9)...

Abstract

There is controversy whether children should have a dietary supply of preformed long-chain polyunsaturated n-3 fatty acids EPA and DHA. The aims of the workshop were to review evidence for a possible benefit of a preformed EPA and/or DHA supply, of data required to set desirable intakes for children aged 2–12 years, and of research priorities. The authors concluded that EPA and DHA intakes per kg body weight may often be low in 2- to 12-year-old children, relative to intakes per kg body weight of breast-fed infants and adult intakes, but reliable data are scarce. Little information is available that increasing dietary intakes of EPA or DHA in children has benefits to physical or mental function or other health endpoints. Studies addressing EPA and DHA intakes and tissue status among groups of children with different dietary habits, and measures of relevant development and health endpoints, are needed for developing potential advice on desirable intakes of EPA and/or DHA in children. At this time it appears prudent to advise that dietary intakes in childhood are consistent with future eating patterns supporting adult health, such as prevention of metabolic disorders and CVD, supporting immune function, and reproductive health. In conclusion, the available information relating dietary EPA and DHA intakes in children aged 2–12 years to growth, development and health is insufficient to derive dietary intake recommendations for EPA and DHA. Adequately designed studies addressing dietary intakes, measures of status and relevant functional or health effects across this age group are needed.

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Corresponding author

*Corresponding author: Professor Berthold Koletzko, fax +49 89 5160 7742, email office.koletzko@med.uni-muenchen.de

References

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1Mozaffarian, D & Rimm, EB (2006) Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA 296, 18851899.
2Kris-Etherton, PM & Innis, S (2007) Position of the American Dietetic Association and Dietitians of Canada: dietary fatty acids. J Am Diet Assoc 107, 15991611.
3Szajewska, H, Horvath, A & Koletzko, B (2006) Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Am J Clin Nutr 83, 13371344.
4Horvath, A, Koletzko, B & Szajewska, H (2007) Effect of supplementation of women in high-risk pregnancies with long-chain polyunsaturated fatty acids on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Br J Nutr 98, 253259.
5Makrides, M, Duley, L & Olsen, SF (2006) Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction. The Cochrane Database of Systematic Reviews 2006, issue 3, CD003402. http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD003402/frame.html.
6Koletzko, B, Cetin, I & Brenna, JT (2007) Dietary fat intakes for pregnant and lactating women. Br J Nutr 98, 873877.
7Koletzko, B, Lien, E, Agostoni, C, et al. (2008) The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perinat Med 36, 514.
8Food and Agriculture Organization & World Health Organization (1994) Fats and Oils in Human Nutrition. FAO Food and Nutrition Paper no. 57. Rome: FAO.
9Innis, SM & Elias, SL (2003) Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. Am J Clin Nutr 77, 473478.
10Meyer, BJ, Mann, NJ, Lewis, JL, et al. (2003) Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids. Lipids 38, 391398.
11Astorg, P, Arnault, N, Czernichow, S, et al. (2004) Dietary intakes and food sources of n-6 and n-3 PUFA in French adult men and women. Lipids 39, 527535.
12Welch, AA, Lund, E, Amiano, P, et al. (2002) Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 5, 12731285.
13United States Department of Agriculture Agricultural Research Service (2007) Nutrient Intakes from Food: Mean Amounts Consumed per Individual, One Day, 2003–2004. http://www.ars.usda.gov/SP2UserFiles/Place/12355000/pdf/0506/Table_2_NIF_05.pdf.
14Koletzko, B, Rodriguez-Palmero, M, Demmelmair, H, et al. (2001) Physiological aspects of human milk lipids. Early Hum Dev 65, Suppl., S3S18.
15Ailhaud, G, Massiera, F, Weill, P, et al. (2006) Temporal changes in dietary fats: role of n-6 polyunsaturated fatty acids in excessive adipose tissue development and relationship to obesity. Prog Lipid Res 45, 203236.
16World Health Organization & Food and Agriculture Organization (2004) Vitamin and Mineral Requirements in Human Nutrition. Joint FAO/WHO Expert Consultation on Human Vitamin and Mineral Requirements. Geneva: WHO/FAO.
17Institute of Medicine (2005) Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: The National Academies Press.
18Davis, BC & Kris-Etherton, PM (2003) Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications. Am J Clin Nutr 78, 640S646S.
19Akabas, SR & Deckelbaum, RJ (2006) Summary of a workshop on n-3 fatty acids: current status of recommendations and future directions. Am J Clin Nutr 83, 1536S1538S.
20Cheatham, CL, Colombo, J & Carlson, SE (2006) n-3 Fatty acids and cognitive and visual acuity development: methodologic and conceptual considerations. Am J Clin Nutr 83, 1458S1466S.
21Carpentier, YA, Portois, L & Malaisse, WJ (2006) n-3 Fatty acids and the metabolic syndrome. Am J Clin Nutr 83, 1499S1504S.
22Sijben, JWC & Calder, PC (2007) Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. Proc Nutr Soc 66, 237259.
23Eilander, A, Hundscheid, DC, Osendarp, SJ, et al. (2007) Effects of n-3 long chain polyunsaturated fatty acid supplementation on visual and cognitive development throughout childhood: a review of human studies. Prostaglandins Leukot Essent Fatty Acids 76, 189203.
24Beblo, S, Reinhardt, H, Muntau, AC, et al. (2001) Fish oil supplementation improves visual evoked potentials in children with phenylketonuria. Neurology 57, 14881491.
25Beblo, S, Reinhardt, H, Demmelmair, H, et al. (2007) Effect of fish oil supplementation on fatty acid status, coordination, and fine motor skills in children with phenylketonuria. J Pediatr 150, 479484.
26Agostoni, C, Massetto, N, Biasucci, G, et al. (2000) Effects of long-chain polyunsaturated fatty acid supplementation on fatty acid status and visual function in treated children with hyperphenylalaninemia. J Pediatr 137, 504509.
27Agostoni, C, Verduci, E, Massetto, N, et al. (2003) Long term effects of long chain polyunsaturated fats in hyperphenylalaninemic children. Arch Dis Child 88, 582583.
28Stevens, L, Zhang, W, Peck, L, et al. (2003) EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids 38, 10071021.
29Richardson, AJ & Puri, BK (2002) A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry 26, 233239.
30Richardson, AJ & Montgomery, P (2005) The Oxford–Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115, 13601366.
31Hirayama, S, Hamazaki, T & Terasawa, K (2004) Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder – a placebo-controlled double-blind study. Eur J Clin Nutr 58, 467473.
32Voigt, RG, Llorente, AM, Jensen, CL, et al. (2001) A randomized, double-blind, placebo-controlled trial of docosahexaenoic acid supplementation in children with attention-deficit/hyperactivity disorder. J Pediatr 139, 189196.
33Ells, LJ, Hillier, FC & Summerbell, CD (2007) A Systematic Review of the Effect of Nutrition, Diet and Dietary Change on Learning, Education and Performance of Children of Relevance to UK Schools. Middlesbrough, UK: University of Teesside, School of Health & Social Care, Centre for Food, Physical Activity and Obesity Research.
34Calder, PC (2006) n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83, 1505S1519S.
35Krauss-Etschmann, S, Hartl, D, Rzehak, P, et al. (2008) Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-β levels after fish oil supplementation of pregnant women. J Allergy Clin Immunol 121, 464470.
36Nagakura, T, Matsuda, S, Shichijyo, K, et al. (2000) Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. Eur Respir J 16, 861865.
37Parsons, TJ, Manor, O & Power, C (2006) Physical activity and change in body mass index from adolescence to mid-adulthood in the 1958 British cohort. Int J Epidemiol 35, 197204.
38Lanigan, J, Turnbull, B & Singhal, A (2007) Toddler diets in the UK: deficiencies and imbalances. 2. Relationship of toddler diet to later health. J Fam Health Care 17, 197200.
39Prentice, A, Branca, F, Decsi, T, et al. (2004) Energy and nutrient dietary reference values for children in Europe: methodological approaches and current nutritional recommendations. Br J Nutr 92, Suppl. 2, S83S146.
40Atkinson, SA & Koletzko, B (2007) Determining life-stage groups and extrapolating nutrient intake values (NIVs). Food Nutr Bull 28, S61S76.
41Blank, C, Neumann, MA, Makrides, M, et al. (2002) Optimizing DHA levels in piglets by lowering the linoleic acid to α-linolenic acid ratio. J Lipid Res 43, 15371543.
42Schaeffer, L, Gohlke, H, Muller, M, et al. (2006) Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 15, 17451756.
43Ungar, D, Joffe, S & Kodish, E (2006) Children are not small adults: documentation of assent for research involving children. J Pediatr 149, S31S33.
44Knudson, PL (2002) Research with children. Arch Med Res 33, 203204.
45Cohen, JT, Bellinger, DC, Connor, WE, et al. (2005) A quantitative risk–benefit analysis of changes in population fish consumption. Am J Prev Med 29, 325334.
46Sioen, I, De, HS, Verbeke, W, et al. (2008) Fish consumption is a safe solution to increase the intake of long-chain n-3 fatty acids. Public Health Nutr 11, 11071116.
47Oken, E, Radesky, JS, Wright, RO, et al. (2008) Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. Am J Epidemiol 167, 11711181.
48Halldorsson, TI, Meltzer, HM, Thorsdottir, I, et al. (2007) Is high consumption of fatty fish during pregnancy a risk factor for fetal growth retardation? A study of 44 824 Danish pregnant women. Am J Epidemiol 166, 687696.
49Agence Française de Sécurité Sanitaire des Aliments, Centre Nationale d'Etudes et de Recommendations sur la Nutrition et l'Alimentation & Centre National de la Recherche Scientifique (2001) Apports Nutritionnels Conseilles pour la Population Française (Dietary Advice for the French Population), 3rd ed.Paris: Editions Tec & Doc.
50Health Council of The Netherlands (2001) Dietary Reference Intakes: Energy, Proteins, Fats, and Digestible Carbohydrates, publication no. 2001/19. The Hague: Health Council of The Netherlands.
51Rajala, M (2001) Nutrition and diet for healthy lifestyles in Europe: science and policy implications. Public Health Nutr 4, 339340.
52World Health Organization (2003) Diet, Nutrition and the Prevention of Chronic Diseases. Joint WHO/FAO Expert Consultation. WHO Technical Report Series no. 916. Geneva: WHO.
53UK Scientific Advisory Committee on Nutrition (2004) Advice on Fish Consumption: Benefits and Risks. London: The Stationery Office.
54Cunnane, SC, Drevon, CA, Harris, B, et al. (2004) Recommendations for Intake of Polyunsaturated Fatty Acids in Healthy Adults. Tiverton, UK: International Society for the Study of Fatty Acids and Lipids.
55Brasseur, D, Delzenne, N, Henderickx, H, et al. (2004) Recommandations et Allégations Concernant les Acides Gras Oméga-3 (Recommendations and Claims Concerning Omega-3 Fatty Acids). Brussels: Conseil Supérieur d'Hygiène.
56Deutsche Gesellschaft für Ernährung (German Nutrition Society) (2005) Nutrition Report 2004. Bonn: DGE.

Keywords

Dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in children – a workshop report

  • Berthold Koletzko (a1), Ricardo Uauy (a2) (a3), Andreu Palou (a4) (a5), Frans Kok (a6), Gerard Hornstra (a7), Ans Eilander (a8), Diego Moretti (a8), Saskia Osendarp (a8), Peter Zock (a8) and Sheila Innis (a9)...

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