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A comparison of the effect of a Growing Up Milk – Lite (GUMLi) v. cows’ milk on longitudinal dietary patterns and nutrient intakes in children aged 12–23 months: the GUMLi randomised controlled trial

  • Amy L. Lovell (a1), Peter S. W. Davies (a2), Rebecca J. Hill (a2), Tania Milne (a3), Misa Matsuyama (a2), Yannan Jiang (a4), Rachel X. Chen (a4), Cameron C. Grant (a5) (a6) (a7) and Clare R. Wall (a1)...

Abstract

The second year of life is a period of nutritional vulnerability. We aimed to investigate the dietary patterns and nutrient intakes from 1 to 2 years of age during the 12-month follow-up period of the Growing Up Milk – Lite (GUMLi) trial. The GUMLi trial was a multi-centre, double-blinded, randomised controlled trial of 160 healthy 1-year-old children in Auckland, New Zealand and Brisbane, Australia. Dietary intakes were collected at baseline, 3, 6, 9 and 12 months post-randomisation, using a validated FFQ. Dietary patterns were identified using principal component analysis of the frequency of food item consumption per d. The effect of the intervention on dietary patterns and intake of eleven nutrients over the duration of the trial were investigated using random effects mixed models. A total of three dietary patterns were identified at baseline: ‘junk/snack foods’, ‘healthy/guideline foods’ and ‘breast milk/formula’. A significant group difference was observed in ‘breast milk/formula’ dietary pattern z scores at 12 months post-randomisation, where those in the GUMLi group loaded more positively on this pattern, suggesting more frequent consumption of breast milk. No difference was seen in the other two dietary patterns. Significant intervention effects were seen on nutrient intake between the GUMLi (intervention) and cows’ milk (control) groups, with lower protein and vitamin B12, and higher Fe, vitamin D, vitamin C and Zn intake in the GUMLi (intervention) group. The consumption of GUMLi did not affect dietary patterns, however, GUMLi participants had lower protein intake and higher Fe, vitamins D and C and Zn intake at 2 years of age.

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Corresponding author

*Corresponding author: A. L. Lovell, fax +64 9 3035962, email a.lovell@auckland.ac.nz

References

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1. National Health and Medical Research Council (2012) Infant Feeding Guidelines: Summary. Canberra: National Health and Medical Research Council.
2. Birch, L, Savage, JS & Ventura, A (2007) Influences on the development of children’s eating behaviours: from infancy to adolescence. Can J Diet Pract Res 68, s1s56.
3. Northstone, K & Emmett, P (2013) The associations between feeding difficulties and behaviours and dietary patterns at 2 years of age: the ALSPAC cohort. Matern Child Nutr 9, 533542.
4. Hilger, J, Goerig, T, Weber, P, et al. (2015) Micronutrient intake in healthy toddlers: a multinational perspective. Nutrients 7, 69386955.
5. Webb, K, Rutishauser, I & Knezevic, N (2008) Foods, nutrients and portions consumed by a sample of Australian children aged 16–24 months. Nutr Diet 65, 5665.
6. Livingstone, M, Robson, PJ & Wallace, J (2004) Issues in dietary intake assessment of children and adolescents. Br J Nutr 92, Suppl. 2, S213–S222.
7. Robinson, S, Marriott, L, Poole, J, et al. (2007) Dietary patterns in infancy: the importance of maternal and family influences on feeding practice. Br J Nutr 98, 10291037.
8. Ambrosini, GL (2014) Childhood dietary patterns and later obesity: a review of the evidence. Proc Nutr Soc 73, 137146.
9. Jolliffe, I (2002) Principal Component Analysis. Wiley Online Library.
10. Hu, FB (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 13, 39.
11. Smithers, LG, Golley, RK, Brazionis, L, et al. (2011) Characterizing whole diets of young children from developed countries and the association between diet and health: a systematic review. Nutr Rev 69, 449467.
12. Smithers, LG, Brazionis, L, Golley, RK, et al. (2012) Associations between dietary patterns at 6 and 15 months of age and sociodemographic factors. Eur J Clin Nutr 66, 658666.
13. Baird, J, Poole, J, Robinson, S, et al. (2008) Milk feeding and dietary patterns predict weight and fat gains in infancy. Paediatr Perinat Epidemiol 22, 575586.
14. Harvey, NC, Robinson, SM, Crozier, SR, et al. (2009) Breast-feeding and adherence to infant feeding guidelines do not influence bone mass at age 4 years. Br J Nutr 102, 915920.
15. Robinson, SM, Marriott, LD, Crozier, SR, et al. (2009) Variations in infant feeding practice are associated with body composition in childhood: a prospective cohort study. J Clin Endocrinol Metab 94, 27992805.
16. Kiefte-de Jong, JC, de Vries, JH, Bleeker, SE, et al. (2013) Socio-demographic and lifestyle determinants of ‘Western-like’ and ‘Health conscious’ dietary patterns in toddlers. Br J Nutr 109, 137147.
17. Smithers, LG, Golley, RK, Brazionis, L, et al. (2012) Dietary patterns of infants and toddlers are associated with nutrient intakes. Nutrients 4, 935948.
18. Shin, KO, Oh, S & Park, HS (2007) Empirically derived major dietary patterns and their associations with overweight in Korean preschool children. Br J Nutr 98, 416421.
19. Hojsak, I, Bronsky, J, Campoy, C, et al. (2018) Young child formula: a position paper by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 66, 177185.
20. Przyrembel, H & Agostoni, C (2013) Growing-up milk: a necessity or marketing? World Rev Nutr Diet 108, 49–55.
21. European Commission, Directorate-General for Health and Food Safety (2016) Young Child Formulae: Background Information. Brussels: European Commission.
22. European Commission, Directorate-General for Health and Food Safety (2016) Report from the Commission to the European Parliament and the Council on Young Child Formulae. Brussels: European Commission.
23. Bell, LK, Golley, RK, Daniels, L, et al. (2013) Dietary patterns of Australian children aged 14 and 24 months, and associations with socio-demographic factors and adiposity. Eur J Clin Nutr 67, 638645.
24. Wall, CR, Hill, RJ, Lovell, AL, et al. (2019) A multi-center, double blind, randomised, placebo controlled trial to evaluate the effect of consuming Growing Up Milk ‘lite’ on body composition in children aged 12–23 months. Am J Clin Nutr (In the Press).
25. Watson, EO, Heath, AM, Taylor, RW, et al. (2015) Relative validity and reproducibility of an FFQ to determine nutrient intakes of New Zealand toddlers aged 12–24 months. Public Health Nutr 18, 32653271.
26. Mills, VC, Skidmore, PM, Watson, EO, et al. (2015) Relative validity and reproducibility of a food frequency questionnaire for identifying the dietary patterns of toddlers in New Zealand. J Acad Nutr Diet 115, 551558.
27. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2013) Scientific opinion on nutrient requirements and dietary intakes of infants and young children in the European Union. EFSA J 11, 3408.
28. Taylor, BJ, Heath, AM, Galland, BC, et al. (2011) Prevention of overweight in infancy (POI. nz) study: a randomised controlled trial of sleep, food and activity interventions for preventing overweight from birth. BMC Public Health 11, 942.
29. Huang, TT, Roberts, SB, Howarth, NC, et al. (2005) Effect of screening out implausible energy intake reports on relationships between diet and BMI. Obes Res 13, 12051217.
30. Cattell, RB (1966) The scree test for the number of factors. Multivariate Behav Res 1, 245276.
31. Gorsuch, RL (1974) Factor Analysis. Philadelphia, PA: WB Saunders.
32. Twisk, J, Kemper, H & Mellenbergh, GJ (1994) Mathematical and analytical aspects of tracking. Epidemiol Rev 16, 165183.
33. Luque, V, Escribano, J, Closa-Monasterolo, R, et al. (2018) Unhealthy dietary patterns established in infancy track to mid-childhood: the EU childhood obesity project. J Nutr 148, 752759.
34. National Health and Medical Research Council (2006) Nutrient Reference Values for Australia and New Zealand Including Recommended Dietary Intakes. Canberra: National Health and Medical Research Council.
35. Carriquiry, AL (1999) Assessing the prevalence of nutrient inadequacy. Public Health Nutr 2, 2334.
36. Food and Nutrition Board, Institute of Medicine (2000) Dietary Reference Intakes: Applications in Dietary Assessment. Washington, DC: Institute of Medicine.
37. Ystrom, E, Niegel, S & Vollrath, ME (2009) The impact of maternal negative affectivity on dietary patterns of 18‐month‐old children in the Norwegian Mother and Child Cohort Study. Matern Child Nutr 5, 234242.
38. Lioret, S, Betoko, A, Forhan, A, et al. (2015) Dietary patterns track from infancy to preschool age: cross-sectional and longitudinal perspectives. J Nutr 145, 775782.
39. Wall, CR, Thompson, J, Robinson, E, et al. (2013) Dietary patterns of children at 3.5 and 7 years of age: a New Zealand birth cohort study. Acta Paediatr 102, 137142.
40. Bocquet, A, Bresson, JL, Briend, A, et al. (2003) Alimentation du nourrisson et de l’enfant en bas âge. Réalisation pratique (Feeding infants and toddlers. Practical realisation). Arch Pediatr 10, 7681.
41. Ghisolfi, J, Fantino, M, Turck, D, et al. (2013) Nutrient intakes of children aged 1–2 years as a function of milk consumption, cows’ milk or growing-up milk. Public Health Nutr 16, 524534.
42. Bramhagen, AC & Axelsson, I (1999) Iron status of children in southern Sweden: effects of cow’s milk and follow-on formula. Acta Paediatr 88, 13331337.
43. Walton, J & Flynn, A (2013) Nutritional adequacy of diets containing growing up milks or unfortified cow’s milk in Irish children (aged 12–24 months). Food Nutr Res 57, 21836.
44. Gibson, S & Sidnell, A (2014) Nutrient adequacy and imbalance among young children aged 1–3 years in the UK. Nutr Bull 39, 172180.
45. Soh, P, Ferguson, EL, McKenzie, JE, et al. (2002) Dietary intakes of 6–24-month-old urban South Island New Zealand children in relation to biochemical iron status. Public Health Nutr 5, 339346.
46. Virtanen, MA, Svahn, C, Viinikka, LU, et al. (2001) Iron‐fortified and unfortified cow’s milk: effects on iron intakes and iron status in young children. Acta Paediatr 90, 724731.
47. Sazawal, S, Dhingra, U, Dhingra, P, et al. (2010) Micronutrient fortified milk improves iron status, anemia and growth among children 1–4 years: a double masked, randomized, controlled trial. PLoS ONE 5, e12167.
48. Szymlek-Gay, EA, Ferguson, EL, Heath, AM, et al. (2009) Food-based strategies improve iron status in toddlers: a randomized controlled trial. Am J Clin Nutr 90, 15411551.
49. Atkins, LA, McNaughton, SA, Campbell, KJ, et al. (2016) Iron intakes of Australian infants and toddlers: findings from the Melbourne infant feeding, activity and nutrition trial (InFANT) program. Br J Nutr 115, 285293.
50. Hower, J, Knoll, A, Ritzenthaler, KL, et al. (2013) Vitamin D fortification of growing up milk prevents decrease of serum 25-hydroxyvitamin D concentrations during winter: a clinical intervention study in Germany. Eur J Pediatr 172, 15971605.
51. Houghton, LA, Gray, AR, Szymlek-Gay, EA, et al. (2011) Vitamin D-fortified milk achieves the targeted serum 25-hydroxyvitamin D concentration without affecting that of parathyroid hormone in New Zealand toddlers. J Nutr 141, 18401846.
52. Food Standards Australia New Zealand (2012) Australia New Zealand Food Standards Code – Standard 1.3.2. Vitamins and Minerals. Canberra: FSANZ.
53. Akkermans, MD, Eussen, SR, van der Horst-Graat, JM, et al. (2017) A micronutrient-fortified young-child formula improves the iron and vitamin D status of healthy young European children: a randomized, double-blind controlled trial. Am J Clin Nutr 105, 391399.
54. Calvert, C, Cade, J, Barrett, JH, et al. (1997) Using cross-check questions to address the problem of mis-reporting of specific food groups on Food Frequency Questionnaires. UKWCS Steering Group. United Kingdom Women’s Cohort Study Steering Group. Eur J Clin Nutr 51, 708712.
55. Movassagh, EZ, Baxter-Jones, AD, Kontulainen, S, et al. (2017) Tracking dietary patterns over 20 years from childhood through adolescence into young adulthood: the Saskatchewan Pediatric Bone Mineral Accrual Study. Nutrients 9, 990.
56. Tucker, KL (2010) Dietary patterns, approaches, and multicultural perspective. Appl Physiol Nutr Metab 35, 211218.
57. EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA) (2010) Scientific opinion on dietary reference values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. EFSA J 8, 14611568.
58. FAO, WHO (2010) Expert Consultation on Fats and Fatty Acids in Human Nutrition: Fats and Fatty Acids in Human Nutrition: Report of an Expert Consultation, 10–14 November 2008. Food and Agriculture Organization of the United Nation.

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