1 O'Keefe, JH, Gheewala, NM & O'Keefe, JO (2008) Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol 51, 249–255.
2 Bazzano, LA, He, J, Ogden, LG, et al. (2002) Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am J Clin Nutr 76, 93–99.
3 Joshipura, KJ, Ascherio, A, Manson, JE, et al. (1999) Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 282, 1233–1239.
4 Joshipura, KJ, Hu, FB, Manson, JE, et al. (2001) The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 134, 1106–1114.
5 Appel, LJ, Moore, TJ, Obarzanek, E, et al. (1997) A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336, 1117–1124.
6 Hamer, M & Chida, Y (2007) Intake of fruit, vegetables, and antioxidants and risk of type 2 diabetes: systematic review and meta-analysis. J Hypertens 25, 2361–2369.
7 Dembinska-Kiec, A, Mykkanen, O, Kiec-Wilk, B, et al. (2008) Antioxidant phytochemicals against type 2 diabetes. Br J Nutr 99, E Suppl. 1, ES109–ES117.
8 Marchesini, G, Brizi, M, Bianchi, G, et al. (2001) Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50, 1844–1850.
9 van Dokkum, W, Frølich, W, Saltmarsh, M, et al. (2008) The health effects of bioactive plant components in food: results and opinions of the EU COST 926 action. Nutr Bull 33, 133–139.
10 Scalbert, A & Williamson, G (2000) Dietary intake and bioavailability of polyphenols. J Nutr 130, 2073S–2085S.
11 Moore, T (1929) Vitamin A and carotene: the association of vitamin A activity with carotene in the carrot root. Biochem J 23, 803–811.
12 Metzger, BT, Barnes, DM & Reed, JD (2008) Purple carrot (Daucus carota L.) polyacetylenes decrease lipopolysaccharide-induced expression of inflammatory proteins in macrophage and endothelial cells. J Agric Food Chem 56, 3554–3560.
13 Sun, T, Simon, PW & Tanumihardjo, SA (2009) Antioxidant phytochemicals and antioxidant capacity of biofortified carrots (Daucus carota L.) of various colors. J Agric Food Chem 57, 4142–4147.
14 Grassmann, J, Schnitzler, WH & Habegger, R (2007) Evaluation of different coloured carrot cultivars on antioxidative capacity based on their carotenoid and phenolic contents. Int J Food Sci Nutr 58, 603–611.
15 Charron, CS, Kurilich, AC, Clevidence, BA, et al. (2009) Bioavailability of anthocyanins from purple carrot juice: effects of acylation and plant matrix. J Agric Food Chem 57, 1226–1230.
16 Christensen, LP & Kreutzmann, S (2007) Determination of polyacetylenes in carrot roots (Daucus carota L.) by high-performance liquid chromatography coupled with diode array detection. J Sep Sci 30, 483–490.
17 Hozawa, A, Jacobs, DR Jr, Steffes, MW, et al. (2009) Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. J Hypertens 27, 237–242.
18 Yanagisawa, A, Suzuki, K, Kimura, A, et al. (2009) Possible protective effect of serum β-carotene levels on the association between interleukin-1B C-31T polymorphism and hypertension in a Japanese population. Clin Nutr 28, 198–202.
19 Liu, S, Ajani, U, Chae, C, et al. (1999) Long-term β-carotene supplementation and risk of type 2 diabetes mellitus: a randomized controlled trial. JAMA 282, 1073–1075.
20 Kataja-Tuomola, M, Sundell, JR, Mannisto, S, et al. (2008) Effect of α-tocopherol and β-carotene supplementation on the incidence of type 2 diabetes. Diabetologia 51, 47–53.
21 Paiva, SA & Russell, RM (1999) β-Carotene and other carotenoids as antioxidants. J Am Coll Nutr 18, 426–433.
22 El-Agamey, A, Lowe, GM, McGarvey, DJ, et al. (2004) Carotenoid radical chemistry and antioxidant/pro-oxidant properties. Arch Biochem Biophys 430, 37–48.
23 Tapiero, H, Townsend, DM & Tew, KD (2004) The role of carotenoids in the prevention of human pathologies. Biomed Pharmacother 58, 100–110.
24 Lin, WT, Huang, CC, Lin, TJ, et al. (2009) Effects of β-carotene on antioxidant status in rats with chronic alcohol consumption. Cell Biochem Funct 27, 344–350.
25 Maritim, A, Dene, BA, Sanders, RA, et al. (2002) Effects of β-carotene on oxidative stress in normal and diabetic rats. J Biochem Mol Toxicol 16, 203–208.
26 Furusho, T, Kataoka, E, Yasuhara, T, et al. (2002) Administration of β-carotene suppresses lipid peroxidation in tissues and improves the glucose tolerance ability of streptozotocin-induced diabetic rats. Int J Vitam Nutr Res 72, 71–76.
27 Kris-Etherton, PM, Hecker, KD, Bonanome, A, et al. (2002) Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med 113, Suppl. 9B, 71S–88S.
28 Galvano, F, La Fauci, L, Lazzarino, G, et al. (2004) Cyanidins: metabolism and biological properties. J Nutr Biochem 15, 2–11.
29 Cignarella, A, Nastasi, M, Cavalli, E, et al. (1996) Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 84, 311–322.
30 Valcheva-Kuzmanova, S, Kuzmanov, K, Mihova, V, et al. (2007) Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet. Plant Foods Hum Nutr 62, 19–24.
31 Guo, H, Ling, W, Wang, Q, et al. (2007) Effect of anthocyanin-rich extract from black rice (Oryza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats. Plant Foods Hum Nutr 62, 1–6.
32 Shindo, M, Kasai, T, Abe, A, et al. (2007) Effects of dietary administration of plant-derived anthocyanin-rich colors to spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 53, 90–93.
33 Stanhope, KL & Havel, PJ (2008) Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Curr Opin Lipidol 19, 16–24.
34 Buettner, R, Scholmerich, J & Bollheimer, LC (2007) High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 15, 798–808.
35 Poudyal, H, Campbell, F & Brown, L (2010) Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. J Nutr 140, 946–953.
36 Zhang, G & Hamaker, BR (2009) Slowly digestible starch: concept, mechanism, and proposed extended glycemic index. Crit Rev Food Sci Nutr 49, 852–867.
37 Lee, J, Durst, RW & Wrolstad, RE (2005) Determination of total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants, and wines by the pH differential method: collaborative study. J AOAC Int 88, 1269–1278.
38 Brown, L, Fenning, A, Chan, V, et al. (2002) Echocardiographic assessment of cardiac structure and function in rats. Heart Lung Circ 11, 167–173.
39 Brown, L, Duce, B, Miric, G, et al. (1999) Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin–angiotensin system. J Am Soc Nephrol 10, Suppl. 11, S143–S148.
40 Sim, AS, Salonikas, C, Naidoo, D, et al. (2003) Improved method for plasma malondialdehyde measurement by high-performance liquid chromatography using methyl malondialdehyde as an internal standard. J Chromatogr B Analyt Technol Biomed Life Sci 785, 337–344.
41 Singh, VN, Singh, M & Venkitasubramanian, TA (1969) Early effects of feeding excess vitamin A: mechanism of fatty liver production in rats. J Lipid Res 10, 395–401.
42 Gerber, LE & Erdman, JW Jr (1979) Effect of retinoic acid and retinyl acetate feeding upon lipid metabolism in adrenalectomized rats. J Nutr 109, 580–589.
43 Ziouzenkova, O, Orasanu, G, Sharlach, M, et al. (2007) Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med 13, 695–702.
44 Pan, J & Baker, KM (2007) Retinoic acid and the heart. Vitam Horm 75, 257–283.
45 Lu, L, Yao, T, Zhu, YZ, et al. (2003) Chronic all-trans retinoic acid treatment prevents medial thickening of intramyocardial and intrarenal arteries in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 285, H1370–H1377.
46 Muller, K, Carpenter, KL, Challis, IR, et al. (2002) Carotenoids induce apoptosis in the T-lymphoblast cell line Jurkat E6.1. Free Radic Res 36, 791–802.
47 Siems, W, Capuozzo, E, Crifo, C, et al. (2003) Carotenoid cleavage products modify respiratory burst and induce apoptosis of human neutrophils. Biochim Biophys Acta 1639, 27–33.
48 Siems, W, Sommerburg, O, Schild, L, et al. (2002) β-Carotene cleavage products induce oxidative stress in vitro by impairing mitochondrial respiration. FASEB J 16, 1289–1291.
49 Du, X, Edelstein, D, Obici, S, et al. (2006) Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest 116, 1071–1080.
50 Steinberg, HO, Tarshoby, M, Monestel, R, et al. (1997) Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 100, 1230–1239.
51 van Heerebeek, L, Somsen, A & Paulus, WJ (2009) The failing diabetic heart: focus on diastolic left ventricular dysfunction. Curr Diab Rep 9, 79–86.
52 Mene, P & Punzo, G (2008) Uric acid: bystander or culprit in hypertension and progressive renal disease? J Hypertens 26, 2085–2092.
53 Hultcrantz, R, Mengarelli, S & Strandvik, B (1986) Morphological findings in the liver of children with cystic fibrosis: a light and electron microscopical study. Hepatology 6, 881–889.
54 Hubbell, RB, Mendel, LB & Wakeman, AJ (1937) New salt mixture for use in experimental diets. J Nutr 14, 273–285.