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Association of fish consumption and dietary intake of marine n-3 PUFA with myocardial infarction in a prospective Danish cohort study

  • Anders Gammelmark (a1), Michael S. Nielsen (a1), Christian S. Bork (a1), Søren Lundbye-Christensen (a1) (a2), Anne Tjønneland (a3), Kim Overvad (a1) (a4) and Erik B. Schmidt (a1)...

Abstract

Several studies have investigated the potential benefits of marine n-3 PUFA in CVD, generally suggesting a lower risk of CHD. However, recent trials have questioned these results. This study investigated the association of fish consumption with dietary intake of marine n-3 PUFA with incident myocardial infarction (MI). In a Danish cohort study, 57 053 subjects between 50 and 64 years of age were enrolled from 1993 to 1997. From national registries, we identified all cases of incident MI. Dietary fish consumption was assessed using a semi-quantitative food questionnaire, including twenty-six questions regarding fish intake. In addition, we calculated the intake of total and individual marine n-3 PUFA. During a median follow-up of 17·0 years, we identified 3089 cases of incident MI. For both men and women, a high intake of fatty fish was inversely related to incident MI. Thus, when comparing the highest and the lowest quintile of fatty fish intake, we found a 12 % lower relative risk of MI in men (hazard ratio (HR) 0·88; 95 % CI 0·77, 1·00) and a 22 % lower relative risk in women (HR 0·78; 95 % CI 0·63, 0·96) after adjustments. For women, similar associations were observed for individual and total marine n-3 PUFA. In contrast, intake of lean fish was not associated with MI. In conclusion, incident MI was inversely related to a high intake of fatty fish, but not lean fish. However, test for trends across quintiles was not statistically significant. In general, this study supports the view that consumption of fatty fish may protect against MI.

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Corresponding author

* Corresponding author: A. Gammelmark, email anders.gammelmark@rn.dk

References

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1. He, K, Song, Y, Daviglus, ML, et al. (2004) Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation 109, 27052711.
2. De Caterina, R (2011) n-3 Fatty acids in cardiovascular disease. N Engl J Med 364, 24392450.
3. Rizos, EC, Ntzani, EE, Bika, E, et al. (2012) Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA 308, 10241033.
4. Saravanan, P, Davidson, NC, Schmidt, EB, et al. (2010) Cardiovascular effects of marine omega-3 fatty acids. Lancet 375, 540550.
5. Lemaitre, RN, King, IB, Mozaffarian, D, et al. (2003) n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. Am J Clin Nutr 77, 319325.
6. Bjerregaard, LJ, Joensen, AM, Dethlefsen, C, et al. (2010) Fish intake and acute coronary syndrome. Eur Heart J 31, 2934.
7. Joensen, AM, Overvad, K, Dethlefsen, C, et al. (2011) Marine n-3 polyunsaturated fatty acids in adipose tissue and the risk of acute coronary syndrome. Circulation 124, 12321238.
8. Miyagawa, N, Miura, K, Okuda, N, et al. (2014) Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: a 24-year follow-up of NIPPON DATA80. Atherosclerosis 232, 384389.
9. Daviglus, ML, Stamler, J, Orencia, AJ, et al. (1997) Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med 336, 10461053.
10. de Goede, J, Geleijnse, JM, Boer, JMA, et al. (2010) Marine (n-3) fatty acids, fish consumption, and the 10-year risk of fatal and nonfatal coronary heart disease in a large population of Dutch adults with low fish intake. J Nutr 140, 10231028.
11. Hu, FB, Bronner, L, Willett, WC, et al. (2002) Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 287, 18151821.
12. Streppel, MT, Ocké, MC, Boshuizen, HC, et al. (2008) Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study. Eur Heart J 29, 20242030.
13. Oomen, CM, Feskens, EJ, Räsänen, L, et al. (2000) Fish consumption and coronary heart disease mortality in Finland, Italy, and The Netherlands. Am J Epidemiol 151, 9991006.
14. Yuan, JM, Ross, RK, Gao, YT, et al. (2001) Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai, China. Am J Epidemiol 154, 809816.
15. Amiano, P, Machón, M, Dorronsoro, M, et al. (2013) Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. Nutr Metab Cardiovasc Dis 24, 321327.
16. Ascherio, A, Rimm, EB, Stampfer, MJ, et al. (1995) Dietary intake of marine n-3 fatty acids, fish intake, and the risk of coronary disease among men. N Engl J Med 332, 977982.
17. Burr, ML, Fehily, AM, Gilbert, JF, et al. (1989) Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 344, 757761.
18. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354, 447455.
19. Saito, Y, Yokoyama, M, Origasa, H, et al. (2008) Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis 200, 135140.
20. Kromhout, D, Giltay, EJ & Geleijnse, JM (2010) n-3 Fatty acids and cardiovascular events after myocardial infarction. N Engl J Med 363, 20152026.
21. Rauch, B, Schiele, R, Schneider, S, et al. (2010) OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation 122, 21522159.
22. Galan, P, Kesse-Guyot, E, Czernichow, S, et al. (2010) Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. BMJ 341, c6273.
23. Tjønneland, A, Olsen, A, Boll, K, et al. (2007) Study design, exposure variables, and socioeconomic determinants of participation in Diet, Cancer and Health: a population-based prospective cohort study of 57053 men and women in Denmark. Scand J Public Health 35, 432441.
24. Tjønneland, A, Overvad, K, Haraldsdóttir, J, et al. (1991) Validation of a semiquantitative food frequency questionnaire developed in Denmark. Int J Epidemiol 20, 906912.
25. Andersen, TF, Madsen, M, Jørgensen, J, et al. (1999) The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 46, 263268.
26. Joensen, AM, Jensen, MK, Overvad, K, et al. (2009) Predictive values of acute coronary syndrome discharge diagnoses differed in the Danish National Patient Registry. J Clin Epidemiol 62, 188194.
27. Kris-Etherton, PM, Harris, WS & Appel, LJ (2003) Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 23, 151152.
28. Catapano, AL, Reiner, Z, De Backer, G, et al. (2011) ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis 217, 346.
29. Wu, JHY & Mozaffarian, D (2014) ω-3 fatty acids, atherosclerosis progression and cardiovascular outcomes in recent trials: new pieces in a complex puzzle. Heart 100, 530533.
30. Mozaffarian, D & Wu, JHY (2011) Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58, 20472067.
31. Rodriguez, BL, Sharp, DS, Abbott, RD, et al. (1996) Fish intake may limit the increase in risk of coronary heart disease morbidity and mortality among heavy smokers. The Honolulu Heart Program. Circulation 94, 952956.
32. Eshak, ES, Iso, H, Yamagishi, K, et al. (2014) Modification of the excess risk of coronary heart disease due to smoking by seafood/fish intake. Am J Epidemiol 179, 11731181.
33. London, B, Albert, C, Anderson, ME, et al. (2007) Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop. Circulation 116, 320335.
34. Christensen, JH (2003) n-3 Fatty acids and the risk of sudden cardiac death. Emphasis on heart rate variability. Dan Med Bull 50, 347367.
35. Thies, F, Garry, JMC, Yaqoob, P, et al. (2003) Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet 361, 477485.
36. Calder, PC (2012) The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability. Mol Nutr Food Res 56, 10731080.
37. Eslick, GD, Howe, PRC, Smith, C, et al. (2009) Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis. Int J Cardiol 136, 416.
38. Gammelmark, A, Madsen, T, Varming, K, et al. (2012) Low-dose fish oil supplementation increases serum adiponectin without affecting inflammatory markers in overweight subjects. Nutr Res 32, 1523.
39. Wu, JHY, Cahill, LE & Mozaffarian, D (2013) Effect of fish oil on circulating adiponectin: a systematic review and meta-analysis of randomized controlled trials. J Clin Endocrinol Metab 98, 24512459.
40. Mozaffarian, D & Wu, JHY (2012) (n-3) Fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary? J Nutr 142, 614625.
41. Gammelmark, A, Nielsen, MS, Bork, C, et al. (2016) Adipose tissue content of marine n-3 polyunsaturated fatty acids is inversely associated with myocardial infarction. J Am Coll Cardiol 67, 10081009.
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British Journal of Nutrition
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  • EISSN: 1475-2662
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