1Durrant, KL (2002) Known and hidden sources of caffeine in drug, food, and natural products. J Am Pharm Assoc 42, 625–637.
2Nishimura, H & Nakai, K (1960) Congenital malformations in offspring of mice treated with caffeine. Proc Soc Exp Biol Med 104, 140–142.
3Committee on Toxicity of Chemicals in Foods, Consumer Products and the Environment (COT) (2001) Statement on the Reproductive Effects of Caffeine. London: Food Standards Agency.
4Beaulac-Baillargeon, L & Desrosiers, C (1987) Caffeine-cigarette interaction on fetal growth. Am J Obstet Gynecol 157, 1236–1240.
5Martin, TR & Bracken, MB (1987) The association between low birth weight and caffeine consumption during pregnancy. Am J Epidemiol 126, 813–821.
6Vlajinac, HD, Petrovic, RR, Marinkovic, JM, Sipetic, SB & Adanja, BJ (1997) Effect of caffeine intake during pregnancy on birth weight. Am J Epidemiol 145, 335–338.
7Barr, HM & Streissguth, AP (1991) Caffeine use during pregnancy and child outcome: a 7-year prospective study. Neurotoxicol Teratol 13, 441–448.
8Godel, JC, Pabst, HF, Hodges, PE, Johnson, KE, Froese, GJ & Joffres, MR (1992) Smoking and caffeine and alcohol intake during pregnancy in a northern population: effect on fetal growth. CMAJ 147, 181–188.
9Santos, IS, Victora, CG, Huttly, S & Carvalhal, JB (1998) Caffeine intake and low birth weight: a population-based case–control study. Am J Epidemiol 147, 620–627.
10Clausson, B, Granath, F, Ekbom, A, Lundgren, S, Nordmark, A, Signorello, LB & Cnattingius, S (2002) Effect of caffeine exposure during pregnancy on birth weight and gestational age. Am J Epidemiol 155, 429–436.
11Linn, S, Schoenbaum, SC, Monson, RR, Rosner, B, Stubblefield, PG & Ryan, KJ (1982) No association between coffee consumption and adverse outcomes of pregnancy. N Engl J Med 306, 141–145.
12Mau, G & Netter, P (1974) Are coffee and alcohol consumption risk factors in pregnancy? (article in German). Geburtshilfe Frauenheilkd 34, 1018–1022.
13McDonald, AD, Armstrong, BG & Sloan, M (1992) Cigarette, alcohol, and coffee consumption and prematurity. Am J Public Health 82, 87–90.
14Klebanoff, MA, Levine, RJ, DerSimonian, R, Clemens, JD & Wilkins, DG (1998) Serum caffeine and paraxanthine as markers for reported caffeine intake in pregnancy. Ann Epidemiol 8, 107–111.
15Danhof, M & Breimer, DD (1978) Therapeutic drug monitoring in saliva. Clin Pharmacokinet 3, 39–57.
16Horning, MG, Brown, L, Nowlin, J, Lertratanangkoon, K, Kellaway, P & Zion, TE (1977) Use of saliva in therapeutic drug monitoring. Clin Chem 23, 157–164.
17James, JE, Bruce, MS, Lader, MH & Scott, NR (1989) Self-report reliability and symptomatology of habitual caffeine consumption. Br J Clin Pharmacol 27, 507–514.
18Murray, S, Lake, BG, Gray, S, Edwards, AJ, Springall, C, Bowey, EA, Williamson, G, Boobis, AR & Gooderham, NJ (2001) Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man. Carcinogenesis 22, 1413–1420.
19Fuhr, U, Klittich, K & Staib, AH (1993) Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin Pharmacol 35, 431–436.
20Fontana, RJ, Lown, KS, Paine, MF, Fortlage, L, Santella, RM, Felton, JS, Knize, MG, Greenberg, A & Watkins, PB (1999) Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers. Gastroenterology 117, 89–98.
21Ministry of Agriculture, Fisheries and Food – Food Safety Directorate (1998) Survey of Caffeine and Other Methylxanthines in Energy Drinks and Other Caffeine-Containing Products (updated). 144. Food Survellance Information Sheet. London: MAFF.
22Butler, MA, Lang, NP, Young, JF, Caporaso, NE, Vineis, P, Hayes, RB, Teitel, CH, Massengill, JP, Lawsen, MF & Kadlubar, FF (1992) Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics 2, 116–127.
23Rasbash, J, Browne, W & Goldstein, H (2001) A User's Guide to MLwiN. London: University of London.
24Office for National Statistics (2002) The National Statistics Socio-Economic Classification User Manual, 1st ed.London: HM Stationery Office.
25Barone, JJ & Roberts, HR (1996) Caffeine consumption. Food Chem Toxicol 34, 119–129.
26Butler, MA, Iwasaki, M, Guengerich, FP & Kadlubar, FF (1989) Human cytochrome P-450PA (P-4501A2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci U S A 86, 7696–7700.
27Zaigler, M, Rietbrock, S, Szymanski, J, Dericks-Tan, JSE, Staib, AH & Fuhr, U (2000) Variation of CYP1A2-dependent caffeine metabolism during menstrual cycle in healthy women. Int J Clin Pharmacol Ther 38, 235–244.
28Andersen, MR, Farin, FM & Omiecinski, CJ (1998) Quantification of multiple human cytochrome P450 mRNA molecules using competitive reverse transcriptase-PCR. DNA Cell Biol 17, 231–238.
29Finnstrom, N, Thorn, M, Loof, L & Rane, A (2001) Independent patterns of cytochrome P450 gene expression in liver and blood in patients with suspected liver disease. Eur J Clin Pharmacol 57, 403–409.
30Vineis, P, Malats, N, Lang, M, d'Errico, A, Caporaso, N, Cuzick, J & Boffetta, P (1999) Metabolic Polymorphisms and Susceptibility to Cancer. Lyon: International Agency for Research on Cancer.
31Carrillo, JA, Christensen, M, Ramos, SI, et al. (2000) Evaluation of caffeine as an in vivo probe for CYP1A2 using measurements in plasma, saliva, and urine. Ther Drug Monit 22, 409–417.
32Newton, R, Broughton, LJ, Lind, MJ, Morrison, PJ, Rogers, HJ & Bradbrook, ID (1981) Plasma and salivary pharmacokinetics of caffeine in man. Eur J Clin Pharmacol 21, 45–52.
33Notarianni, LJ, Oliver, SE, Dobrocky, P, Bennett, PN & Silverman, BW (1995) Caffeine as a metabolic probe: a comparison of the metabolic ratios used to assess CYP1A2 activity. Br J Clin Pharmacol 39, 65–69.
34Bracken, MB, Triche, E, Grosso, L, Hellenbrand, K, Belanger, K & Leaderer, BP (2002) Heterogeneity in assessing self-reports of caffeine exposure: implications for studies of health effects. Epidemiology 13, 165–171.
35Aldridge, A, Bailey, J & Neims, AH (1981) The disposition of caffeine during and after pregnancy. Semin Perinatol 5, 310–314.