1 La Vecchia, C (2004) Mediterranean diet and cancer. Public Health Nutr 7, 965–968.
2 Cooke, D, Steward, WP, Gescher, AJ, et al. (2005) Anthocyans from fruits and vegetables – does bright colour signal cancer chemopreventive activity? Eur J Cancer 41, 1931–1940.
3 Surh, YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3, 768–780.
4 Hemingway, RW & Karchesy, JJ (1989) Structural variations in proanthocyanidins and their derivatives. In Chemistry and Significance of Condensed Tannins, pp. 47–60 [Hemingway, RW and Karchesy, JJ, editors]. New York: Plenum Press.
5 Gerhauser, C (2008) Cancer chemopreventive potential of apples, apple juice and apple components. Planta Med 74, 1608–1624.
6 Can-Lan, S, Jian-Min, Y, Woon-Puay, K, et al. (2006) Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies. Carcinogenesis 27, 1310–1315.
7 Carlson, S, Peng, N, Prasain, JK, et al. (2008) Effects of botanical dietary supplements on cardiovascular, cognitive, and metabolic function in males and females. Gend Med 5A, S76–S90.
8 Ye, X, Krohn, RL, Liu, W, et al. (1999) The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol Cell Biochem 196, 99–108.
9 Singh, RP, Tyagi, AK, Dhanalakshmi, S, et al. (2004) Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int J Cancer 108, 733–740.
10 Singletary, KW & Meline, B (2001) Effect of grape seed proanthocyanidins on colon aberrant crypts and breast tumors in a rat dual-organ tumor model. Nutr Cancer 39, 252–258.
11 Engelbrecht, AM, Mattheyse, M, Ellis, B, et al. (2007) Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett 258, 144–153.
12 Kaur, M, Mandair, R, Agarwal, R, et al. (2008) Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells. Nutr Cancer 60, Suppl. 1, 2–11.
13 Landis, SH, Murray, T, Bolden, S, et al. (1999) Cancer statistics. CA Cancer J Clin 49, 8–31.
14 Yeatman, TJ & Chambers, AF (2003) Osteopontin and colon cancer progression. Clin Exp Metastasis 20, 85–90.
15 Clifton, PM (2004) Effect of grape seed extract and quercetin on cardiovascular and endothelial parameters in high risk subjects. J Biomed Biotechnol 5, 272–278.
16 Cavaliere, C, Foglia, P, Marini, F, et al. (2010) The interactive effects of irrigation, nitrogen fertilization rate, delayed harvest and storage on polyphenol content in grape (Vitis vinifera) berry: a factorial experimental design. J Agric Food Chem .
17 Cavaliere, C, Foglia, P, Gubbiotti, R, et al. (2008) Rapid-resolution liquid chromatography/mass spectrometry for determination and quantitation of polyphenols in grape berries. Rapid Commun Mass Spectrom 22, 3089–3099.
18 Marel, AK, Lizard, G, Izard, JC, et al. (2008) Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells. Mol Nutr Food Res 52, 538–548.
19 Benitez, DA, Pozo-Guisado, E, Alvarez-Barrientos, A, et al. (2007) Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell lines. J Androl 28, 282–293.
20 Li, L, Adams, LS, Chen, S, et al. (2009) Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J Agric Food Chem 57, 826–831.
21 Thomasset, S, Teller, N, Cai, H, et al. (2009) Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs? Cancer Chemother Pharmacol 64, 201–211.
22 Veluri, R, Singh, RP, Liu, Z, et al. (2006) Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis 27, 1445–1453.
23 MacKenzie, SH & Clark, AC (2008) Targeting cell death in tumors by activating caspases. Curr Cancer Drug Targets 8, 98–109.
24 Sharma, G, Tyagi, AK, Singh, RP, et al. (2004) Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res Treat 85, 1–12.
25 Nandakumar, V, Singh, T & Katiyar, SK (2008) Multi-targeted prevention and therapy of cancer by protoanthocyanidins. Cancer Lett 269, 378–387.
26 Joshi, SS, Kuszynki, CA & Bagchi, D (2001) The cellular and molecular basis of health benefits of grape seed proanthocyanidins extract. Curr Pharmacol Biotechnol 2, 2187–2200.
27 Kaur, M, Mandair, R, Agarwal, R, et al. (2008) Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells. Nutr Cancer 60, 2–11.
28 Leifert, WR & Abeywardena, MY (2008) Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutr Res 28, 842–850.
29 Gabetta, B, Fuzzati, N, Griffino, A, et al. (2000) Characterization of proanthocyanidins from grape seeds. Fitoterapia 71, 162–175.
30 Weber, HA, Hodges, AE, Guthrie, JR, et al. (2007) Comparison of proanthocyanidins in commercial antioxidants: grape seed and pine bark extracts. J Agric Food Chem 55, 148–156.
31 Saeki, K, Hayakawa, S, Isemura, M, et al. (2000) Importance of a pyrogallol-type structure in catechin compounds for apoptosis-inducing activity. Phytochemistry 53, 391–394.
32 Inaba, H, Nagaoka, Y, Kushima, Y, et al. (2008) Comparative examination of anti-proliferative activities of ( − )-epigallocatechin gallate and ( − )-epigallocatechin against HCT116 colorectal carcinoma cells. Biol Pharm Bull 31, 79–84.
33 Achiwa, Y, Hibasami, H, Katsuzaki, H, et al. (1997) Inhibitory effects of persimmon (Diospyros kaki) extract and related polyphenol compounds on growth of human lymphoid leukemia cells. Biosci Biotechnol Biochem 61, 1099–1101.
34 Hibasami, H, Komiya, T, Achiwa, Y, et al. (1998) Induction of apoptosis in human stomach cancer cells by green tea catechins. Oncol Rep 5, 527–529.
35 Kim, YJ, Park, HJ, Yoon, SH, et al. (2005) Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4. World J Gastroenterol 11, 4674–4678.
36 Nakazato, T, Ito, K, Ikeda, Y, et al. (2000) Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Cancer Res 11, 6040–6049.
37 Wu, PP, Kuo, SC, Huang, WW, et al. (2009) ( − )-Epigallocatechin gallate induced apoptosis in human adrenal cancer NCI-H295 cells through caspase-dependent and caspase-independent pathway. Anticancer Res 29, 1435–1442.