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Association between FADS1 rs174547 and levels of long-chain PUFA: a meta-analysis

Published online by Cambridge University Press:  17 December 2020

Yan Wang
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People’s Republic of China.
Yiwei Tang
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People’s Republic of China.
Ye Ji
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People’s Republic of China.
Wenhui Xu
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People’s Republic of China.
Naeem Ullah
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People’s Republic of China.
Haitao Yu
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People’s Republic of China.
Yixia Wu
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People’s Republic of China.
Lin Xie
Affiliation:
Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, People’s Republic of China.
Corresponding
E-mail address:

Abstract

In the present study, we analysed the effects of SNP rs174547 (T/C) in the fatty acid desaturase 1 (FADS1) gene on long-chain PUFA levels. Four databases were searched to retrieve related literature with keywords such as fatty acid (FA), SNP, FADS1 and rs174547. A meta-analysis of the data was performed using Stata12.0 software, including summary statistics, test for heterogeneity, evaluation of publication bias, subgroup analysis and sensitivity analysis. The associations between rs174547 in FADS1 and seven types of FA, and Δ-5 (D5D) and Δ-6 fatty acid desaturase (D6D) activity were assessed based on the pooled results from eleven papers. A total of 3713 individuals (1529 TT and 2184 TC + CC) were included. The results demonstrated that minor C allele carriers of rs174547 had higher linoleic acid (LA; P < 0·001) and α-linolenic acid (P = 0·020) levels, lower γ-linolenic acid (GLA; P = 0·001) and arachidonic acid (P = 0·024) levels, and lower D5D (P = 0·005) and D6D (P = 0·004) activities than the TT genotype group. Stratification analysis showed that minor C allele carriers of rs174547 had higher LA and lower GLA levels and lower D6D activities in plasma (LA, P < 0·001; GLA, P < 0·001; D6D activity, P < 0·001) samples and in Asian populations (LA, P < 0·001; GLA, P = 0·001; D6D activity, P = 0·001) than the TT genotype group. In conclusion, minor C allele carriers of the SNP rs174547 were associated with decreased activity of D5D and D6D.

Type
Systematic Review and Meta-Analysis
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Nutrition Society

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