There are many indications that humans have a tendency to affiliate with nature, and with other living beings, including non-human species. Examples of such affiliation range from spending time in parks and nature reserves to humanising our companion animals to the point that we accord them family-member status and strongly grieve their passing. Research has also shown that humans can benefit significantly from their relationships with non-human animals. For example, studies have indicated that even the mere observation of animals can result in reduced physiological responding to stressors, and in increased positive mood. In the present review, we propose that findings such as these may provide important information regarding the potential benefits to be derived from incorporating non-human animals into intervention strategies, particularly for children. Of specific relevance for children is their fascination with, and attraction to, non-human animals. There is also the very nonjudgemental nature of human–animal interactions (i.e., unconditional positive regard) that has been argued, among other benefits, to serve as a useful “bridge” for the establishment of rapport between therapist and child. However, despite promising avenues of investigation, the area of animal-assisted intervention remains largely neglected by researchers. In this paper, we call for sound empirical investigation into proposals regarding the potential therapeutic benefits of incorporating non-human animals into intervention programs.