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Two separate pathways for cerebellar LTD: NO-dependent and NO-independent
Published online by Cambridge University Press: 19 May 2011
Abstract
Strong stimulation of parallel fibers (PFs) leads to localized calcium influx and a long-term depression (LTD) of PF responses at the site of stimulation. These same stimuli also induce depression at spatially distant synapses to the same cell that is mediated by the diffusible messenger nitric oxide (NO). The demonstration of two distinct forms of LTD provide an explanation for the absence of the NO/cGMP pathway in cultured cells, [CBÉPEL et al.; LINDEN; VINCENT]
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