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Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

  • J. Alfredo Blakeley-Ruiz (a1) (a2), Carlee S. McClintock (a3), Ralph Lydic (a1) (a2), Helen A. Baghdoyan (a1) (a2), James J. Choo (a3) and Robert L. Hettich (a1) (a2)...


The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.



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Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

  • J. Alfredo Blakeley-Ruiz (a1) (a2), Carlee S. McClintock (a3), Ralph Lydic (a1) (a2), Helen A. Baghdoyan (a1) (a2), James J. Choo (a3) and Robert L. Hettich (a1) (a2)...


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