Published online by Cambridge University Press: 12 April 2004
A dorsalization mechanism is a good candidate for the evolutionary origin of the isocortex, producing a radial and tangential expansion of the dorsal pallium (and perhaps other structures that acquired a cortical phenotype). Evidence suggests that a large part of the dorsal ventricular ridge (DVR) of reptiles and birds derives from the embryonic ventral pallium, whereas the isocortex possibly derives mostly from the dorsal pallium. In early mammals, the development of olfactory-hippocampal associative networks may have been pivotal in facilitating the selection of a larger and more complex dorsal pallium which received both collothalamic and lemnothalamic sensory information. Finally, although it is not clear exactly when mammalian brain expansion began, fossil evidence indicates that this was a late event in mammaliaform evolution.