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Supportive evidence for contribution of the dopamine D2 receptor gene to heritability of stature: linkage and association studies

Published online by Cambridge University Press:  01 March 1999

T. ARINAMI ,
Y. IIJIMA ,
K. YAMAKAWA-KOBAYASHI ,
H. ISHIGURO ,
T. OHTSUKI ,
H. YANAGI ,
Y. SHIMAKURA ,
H. ISHIKAWA  and
H. HAMAGUCHI
T. ARINAMI
Affiliation:
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan
Y. IIJIMA
Affiliation:
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan
K. YAMAKAWA-KOBAYASHI
Affiliation:
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan
H. ISHIGURO
Affiliation:
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan
T. OHTSUKI
Affiliation:
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan
H. YANAGI
Affiliation:
Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan
Y. SHIMAKURA
Affiliation:
Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305–8575, Japan
H. ISHIKAWA
Affiliation:
Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan
H. HAMAGUCHI
Affiliation:
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan
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Abstract

Increases in height were reported in children chronically exposed prenatally and postnatally to D2 receptor-blocking drugs. A possible haplotypic association between stature and the DRD2 gene was also reported. In this study, we examined linkage between stature and DRD2 by genotyping a dinucleotide repeat polymorphism in 79 sib-pairs aged 8–17 years. An association between stature and a putative functional polymorphism in the promoter region of the DRD2 gene was examined in the sib-pairs and in 125 unrelated male adults. All the subjects were Japanese. Linkage (p = 0.004, SIBPAL) and an association (p = 0.009, paired t-test, in the sib-pairs; p = 0.006, ANOVA, in the adults) with stature were suggested. These findings indicate that DRD2 is one of the genes that contribute to heritability of stature.

Type
Research Article
Information
Annals of Human Genetics , Volume 63 , Issue 2 , March 1999 , pp. 147 - 151
Copyright
© University College London 1999

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