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On extending the transmission/disequilibrium test (TDT)

Published online by Cambridge University Press:  01 March 1997

S. R. WILSON
S. R. WILSON
Affiliation:
Centre for Mathematics and its Applications, SMS Australian National University, Canberra, ACT 0200, Australia
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Abstract

The transmission/disequilibrium test (TDT), for evaluation of the null hypothesis of neither linkage nor association between a marker locus and disease, is extended to the more general situation of transmission of two multi-allele marker loci from parents to affected offspring. Transmission probabilities are derived for a generalized single locus disease model, where the disease locus is taken to lie between the two marker loci. There could be unlinked modifier loci for the disease. Examples of the extended TDT are given and it is shown how the contribution from each locus can be evaluated, both separately and jointly.

Type
Research Article
Information
Annals of Human Genetics , Volume 61 , Issue 2 , March 1997 , pp. 151 - 161
Copyright
© University College London 1997

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