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A multistep process for the dispersal of a Y chromosomal lineage in the Mediterranean area

Published online by Cambridge University Press:  02 October 2001

P. MALASPINA
Affiliation:
Department of Biology, University ‘Tor Vergata’, Rome, Italy
M. TSOPANOMICHALOU
Affiliation:
Department of Forensic Sciences, University of Crete, Heraklion, Greece
T. DUMAN
Affiliation:
Pediatrics Department, Ankara University, Turkey
M. STEFAN
Affiliation:
Genetics Department, University of Bucharest, Rumania
A. SILVESTRI
Affiliation:
Department of Biology, University ‘Tor Vergata’, Rome, Italy
B. RINALDI
Affiliation:
Department of Biology, University ‘Tor Vergata’, Rome, Italy
O. GARCIA
Affiliation:
Basque Country Police, Bilbao, Spain
M. GIPARAKI
Affiliation:
Ministry of Health Center for Thalassemia, Athens, Greece
E. PLATA
Affiliation:
Ministry of Health Center for Thalassemia, Athens, Greece
A. I. KOZLOV
Affiliation:
Arct-An C Innovative Laboratory, Moscow, Russian Federation
G. BARBUJANI
Affiliation:
Department of Biology, University of Ferrara, Italy
C. VERNESI
Affiliation:
Department of Biology, University of Ferrara, Italy
F. PAPOLA
Affiliation:
Centro Regionale di Immunoematologia e Tipizzazione Tissutale, L'Aquila, Italy
G. CIAVARELLA
Affiliation:
IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy
D. KOVATCHEV
Affiliation:
Department of Biology, Medical University, Varna, Bulgaria
M. G. KERIMOVA
Affiliation:
Department of Hygiene, Azerbaijan Medical University, Baku, Azerbaijan
N. ANAGNOU
Affiliation:
Institute of Molecular Biology and Biotechnology, Heraklion and University of Athens, Greece
L. GAVRILA
Affiliation:
Genetics Department, University of Bucharest, Rumania
L. VENEZIANO
Affiliation:
Institute of Experimental Medicine, CNR, Rome, Italy
N. AKAR
Affiliation:
Pediatrics Department, Ankara University, Turkey
A. LOUTRADIS
Affiliation:
Ministry of Health Center for Thalassemia, Athens, Greece
E. N. MICHALODIMITRAKIS
Affiliation:
Department of Forensic Sciences, University of Crete, Heraklion, Greece
L. TERRENATO
Affiliation:
Department of Biology, University ‘Tor Vergata’, Rome, Italy
A. NOVELLETTO
Affiliation:
Department of Cell Biology, University of Calabria, Rende, Italy
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Abstract

In this work we focus on a microsatellite-defined Y-chromosomal lineage (network 1.2) identified by us and reported in previous studies, whose geographic distribution and antiquity appear to be compatible with the Neolithic spread of farmers. Here, we set network 1.2 in the Y-chromosomal phylogenetic tree, date it with respect to other lineages associated with the same movements by other authors, examine its diversity by means of tri- and tetranucleotide loci and discuss the implications in reconstructing the spread of this group of chromosomes in the Mediterranean area. Our results define a tripartite phylogeny within HG 9 (Rosser et al. 2000), with the deepest branching defined by alleles T (Haplogroup Eu10) or G (Haplogroup Eu9) at M172 (Semino et al. 2000), and a subsequent branching within Eu9 defined by network 1.2. Population distributions of HG 9 and network 1.2 show that their occurrence in the surveyed area is not due to the spread of people from a single parental population but, rather, to a process punctuated by at least two phases. Our data identify the wide area of the Balkans, Aegean and Anatolia as the possible homeland harbouring the largest variation within network 1.2. The use of recently proposed tests based on the stepwise mutation model suggests that its spread was associated to a population expansion, with a high rate of male gene flow in the Turkish–Greek area.

Type
Research Article
Copyright
University College London 2001

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