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Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3–13.4 by an intragenic polymorphic marker

Published online by Cambridge University Press:  01 May 1998

J. BELLINGHAM ,
K. GREGORY-EVANS  and
C. Y. GREGORY-EVANS
J. BELLINGHAM
Affiliation:
Department of Molecular Genetics, Imperial College School of Medicine, Norfolk Place, London W2 1PG, UK
K. GREGORY-EVANS
Affiliation:
Academic Unit of Ophthalmology, Imperial College School of Medicine, Norfolk Place, London W2 1PG, UK
C. Y. GREGORY-EVANS
Affiliation:
Department of Molecular Genetics, Imperial College School of Medicine, Norfolk Place, London W2 1PG, UK
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Abstract

We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3–13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1. An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3–13.4 maps Irf3 to either mouse chromosome 7 or 17.

Type
Research Article
Information
Annals of Human Genetics , Volume 62 , Issue 3 , May 1998 , pp. 231 - 234
Copyright
© University College London 1998

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