Skip to main content Accessibility help
×
Home

Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

  • J. A. CAVANAUGH (a1), D. F. CALLEN (a2), S. R. WILSON (a3), P. M. STANFORD (a1), M. E. SRAML (a1), M. GORSKA (a1), J. CRAWFORD (a2), S. A. WHITMORE (a2), C. SHLEGEL (a1), S. FOOTE (a4), M. KOHONEN-CORISH (a5) and P. PAVLI (a1)...
    • Published online by Cambridge University Press: 01 July 1998

Abstract

A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al. (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al. 1996; Parkes et al. 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.

Copyright

Corresponding author

Correspondence: J. A. Cavanaugh, Gastroenterology Unit, The Canberra Hospital, PO Box 11, Garran, ACT 2606, Australia. Tel.: 61 262442195. Fax: 61 262815179. E-mail: juleen.cavanaugh@anu.edu.au

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed