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Age-related changes of the 3′APOB-VNTR genotype pool in ageing cohorts

Published online by Cambridge University Press:  01 March 1998

G. De BENEDICTIS ,
L. CAROTENUTO ,
G. CARRIERI ,
M. De LUCA ,
E. FALCONE ,
G. ROSE ,
A. I. YASHIN ,
M. BONAFÈ  and
C. FRANCESCHI
G. De BENEDICTIS
Affiliation:
Cell Biology Dept., University of Calabria, Italy
L. CAROTENUTO
Affiliation:
D.E.I.S., University of Calabria, Italy
G. CARRIERI
Affiliation:
Cell Biology Dept., University of Calabria, Italy
M. De LUCA
Affiliation:
Cell Biology Dept., University of Calabria, Italy I.N.R.C.A., Ancona, Italy
E. FALCONE
Affiliation:
Cell Biology Dept., University of Calabria, Italy
G. ROSE
Affiliation:
Cell Biology Dept., University of Calabria, Italy
A. I. YASHIN
Affiliation:
Max Planck Inst. for Demographic Research, Rostock, Germany Duke University Center for Demographic Studies, USA
M. BONAFÈ
Affiliation:
Department of Biomedical Sciences, University of Modena, Italy
C. FRANCESCHI
Affiliation:
I.N.R.C.A., Ancona, Italy Department of Biomedical Sciences, University of Modena, Italy
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Abstract

The analysis of seven different age cohorts (697 individuals from 10 to 109 years old) revealed age-related changes in the 3′APOB-VNTR genotype pool. By recoding the 3′APOB-VNTR alleles into three size-classes (small, S, 26–34 repeats; medium, M, 35–39 repeats; large, L, 41–55 repeats), an age-related convex trajectory of the frequency of SS homozygotes was found. The frequency of SS in the genotype pool increased from the group aged 10–19 years (3.06±1.74%) to that aged 40–49 years (8.51±4.07%). Then it declined reaching the minimum value in centenarians (1.58±0.90%). The observed trajectory is in agreement with that expected by assuming crossing of mortality curves relevant to subgroups of individuals having different genotypes.

Type
Research Article
Information
Annals of Human Genetics , Volume 62 , Issue 2 , March 1998 , pp. 115 - 122
Copyright
© University College London 1998

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