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Assignment of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) between D3S3118 and GCT4B10 on the short arm of chromosome 3 by somatic cell hybrid analysis

Published online by Cambridge University Press:  01 July 1997

P. J. TOWNSEND
Affiliation:
Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY
M. H. YACOUB
Affiliation:
Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY
P. J. R. BARTON
Affiliation:
Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY
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Abstract

We have determined the chromosomal location of the human cardiac/slow skeleletal muscle troponin C gene (TNNC1) to the short arm of chromosome 3 using somatic cell hybrids. PCR-based analysis of a ‘monochromosomal’ hybrid panel identified the presence of the TNNC1 gene on human chromosome 3 and subsequent analysis of the Genebridge4 radiation hybrid panel located the gene between D3S3118 (7·3cR) and GCT4B10 (4·2cR) with a lod score of >3·0.

Type
SHORT COMMUNICATION
Copyright
© University College London 1997

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