Skip to main content Accessibility help
×
Home

Mid-season targeted selective anthelmintic treatment based on flexible weight gain threshold for nematode infection control in dairy calves

  • A. Merlin (a1), N. Ravinet (a1), A. Madouasse (a1), N. Bareille (a1), A. Chauvin (a1) and C. Chartier (a1)...

Abstract

The suitability of a single mid-season targeted selective treatment (TST) for gastrointestinal nematodes control, based on flexible average daily weight gain (ADWG) thresholds, was investigated in 23 groups of first grazing season calves. In each group, animals were weighed three times: before turnout, at mid-season and at housing. Just after the first weighing, each group was divided in two homogenous sub-groups in terms of age, breed and weight, and randomly allocated to one of two sub-groups intented for two different mid-season anthelmintic treatment strategies: (1) a treatment of all calves composing the sub-group (whole-group treatment (WT)) or (2) a targeted selective weight gain-based treatment (TST) of the animals showing an individual pre-treatment ADWG inferior to the mean pre-treatment ADWG of the corresponding WT sub-group. Anthelmintic treatment (levamisole 7.5 mg/kg BW) was performed 3 to 4 months after turnout. At housing, two parasitological parameters (the anti-Ostertagia ostertagi antibody level-Ostertagia optical density ratio (ODR) and the pepsinogen level) and a clinical parameter (the breech soiling score) were assessed at individual level in each group. Then, the high exposed groups to gastrointestinal nematode (GIN) were defined as groups for which untreated animals exhibited a mean Ostertagia ODR ⩾0.7 and among these groups, the ones characterized by high abomasal damage due to Ostertagia for which untreated animals exhibited a mean pepsinogen level ⩾2.5 U Tyr were also identified. Among TST sub-groups, the treatment ADWG thresholds varied from 338 to 941 g/day and the percentage of treated animals from 28% to 75%. Pre- and post-treatment ADWG as well as parasitological and clinical parameters measured at housing were similar between TST and WT sub-groups including the 17 high exposed groups to GIN. Within these 17 groups, the treatment allowed to significantly improve post-treatment ADWG compared with untreated animals. In the six high exposed groups showing mean pepsinogen level ⩾2.5 U Tyr, the average effect of treatment on post-treatment ADWG was the highest and estimated up to 14 kg after a grazing duration of 4 months. In contrast, in six other groups showing mean Ostertagia ODR<0.7 in untreated animals, no effect of treatment was seen suggesting an absence of production losses related to a low level of GIN infection. This study highlighted the suitability of a convenient mid-season TST strategy for first grazing season calves, based on the use of flexible thresholds of ADWG, allowing similar growth compared with a whole-group treatment while keeping a GIN population in refugia.

Copyright

Corresponding author

References

Hide All
Armour, J and Duncan, M 1987. Arrested larval development in cattle nematodes. Parasitology Today 3, 171176.
Bennema, SC, Vercruysse, J, Morgan, E, Stafford, K, Höglund, J, Demeler, J, von Samson-Himmelstjerna, G and Charlier, J 2010. Epidemiology and risk factors for exposure to gastrointestinal nematodes in dairy herds in Northwestern Europe. Veterinary Parasitology 173, 247254.
Berk, Z, Laurenson, YCSM, Forbes, AB and Kyriazakis, I 2016. Modelling the consequences of targeted selective treatment strategies on performance and emergence of anthelmintic resistance amongst grazing calves. International Journal for Parasitology: Drugs and Drug Resistance 6, 258271.
Charlier, J, Demeler, J, Höglund, J, von Samson-Himmelstjerna, G, Dorny, P and Vercruysse, J 2010. Ostertagia ostertagi in first-season grazing in Belgium, Germany and Sweden: general levels of infection and related management practices. Veterinary Parasitology 171, 9198.
Charlier, J, Dorny, P, Levecke, B, Demeler, J, von Samson-Himmerlstjerna, G, Höglund, J and Vercruysse, J 2011. Serum pepsinogen levels to monitor gastrointestinal nematode infections in cattle revisited. Research in Veterinary Science 90, 451456.
Charlier, J, van der Voort, M, Kenyon, F, Skuce, P and Vercruysse, J 2014. Chasing helminths and their economic impact on farmed ruminants. Trends in Parasitology 30, 361367.
Costa, JCA, Mejita, ME, Martinez, EF and Cabaret, J 1989. El control de la gastroenteritis verminosa bovina en la ‘Pampa humeda’ (Argentina), bajo condiciones de campo, entre 1979 y 1987: Resultados, Limitantes y futuro del mismo. Tecnicrea 15, 317.
Demeler, J, Van Zeveren, AMJ, Kleinschmidt, N, Vercruysse, J, Höglund, J, Koopman, R, Cabaret, J, Claerebout, E, Areskog, M and von Samson-Himmelstjerna, G 2009. Monitoring the efficacy of ivermectin and albendazole against gastrointestinal nematodes of cattle in Northern Europe. Veterinary Parasitology 160, 109115.
Eysker, M and Ploeger, HW 2000. Value of present diagnostic methods for gastrointestinal nematode infections in ruminants. Parasitology 120, 109119.
Fahrenkrog, J 2013. Optimisation of Treatment Strategies to Control Parasitic Infections in Grazing Cattle. PhD thesis, Freie Universistät, Berlin, Germany.
Geurden, T, Chartier, C, Fanke, J, di Regalbono, AF, Traversa, D, von Samson-Himmelstjerna, G, Demeler, J, Vanimisetti, HB, Bartram, DJ and Denwood, MJ 2015. Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe. International Journal for Parasitology: Drugs and Drug Resistance 5, 163171.
Greer, AW, McAnulty, RW and Gibbs, SJ 2010. Performance-based targeted selective anthelmintic treatment regime for grazing dairy calves. In Proceeding of the 4th Australasian Dairy Science Symposium, 31 August–2 September, Christchurch, New Zealand, pp. 385–389.
Höglund, J, Morrison, DA, Charlier, J, Dimander, SO and Larsson, A 2009. Assessing the feasibility of targeted selective treatments for gastrointestinal nematodes in first-season grazing cattle based on mid-season daily weight gains. Veterinary Parasitology 164, 8088.
Höglund, J, Dahlström, F, Sollenberg, S and Hessle, A 2013. Weight gain-based targeted selective treatment (TST) of gastrointestinal nematodes in first-season grazing cattle. Veterinary Parasitology 196, 358365.
Kenyon, F, Greer, AW, Coles, GC, Cringoli, G, Papadopoulos, E, Cabaret, J, Berrag, B, Varady, M, Van Wyk, JA, Thomas, E, Vercruysse, J and Jackson, F 2009. The role of targeted selective treatments in the development of refugia-based approaches to the control of gastrointestinal nematodes of small ruminants. Veterinary Parasitology 164, 311.
Kenyon, F and Jackson, F 2012. Targeted flock/herd and an individual ruminant treatment approaches. Veterinary Parasitology 186, 1017.
Kerboeuf, D, Koch, C, Le Dréan, E and Lacourt, A 2002. Méthode simplifiée de mesure de la concentration en pepsinogène dans le sérum. Revue de Medécine Vétérinaire 153, 707712.
McAnulty, RW, Gibbs, SJ and Greer, AW 2011. Brief communication: Liveweight gain of grazing dairy calves in their first grazing season subjected to a selective anthelmintic treatment (TST) regime. In Proceedings of the 71th New Zealand Society of Animal Production, Invercargill, New Zealand, pp. 301–303.
Merlin, A, Chauvin, A, Madouasse, A, Froger, S, Bareille, N and Chartier, C 2016. Explaining variability in first grazing season heifer growth combining individually measured parasitological and clinical indicators with exposure to gastrointestinal nematode infection based on grazing management practices. Veterinary Parasitology 225, 6169.
Merlin, A, Chauvin, A, Madouasse, A, Lehebel, A, Brisseau, N, Bareille, N and Chartier, C 2017. End-season daily weight gains as rationale for targeted selective treatment against gastrointestinal nematodes in highly exposed first-grazing season cattle. Preventive Veterinary Medicine 138, 104112.
O’Shaughnessy, J, Earley, B, Mee, JF, Doherty, ML, Crosson, P, Barrett, D and de Waal, T 2015. Controlling nematodes in dairy calves using targeted selective treatments. Veterinary Parasitology 209, 221228.
Ploeger, HW, Borgsteede, FHM, Eysker, M and van den Brink, R 1990. Effect of nematode infections on growth performance of calves after stabling on commercial dairy farms. Veterinary Parasitology 36, 7181.
Ploeger, HW, Borgsteede, FHM, Sol, J, Mirck, MH, Huyben, MWC, Kooyman, FNJ and Eysker, M 2000. Cross-sectional serological survey on gastrointestinal and lung nematode infections in first and second-year replacement stock in The Netherlands: relation with management practices use of anthelmintic. Veterinary Parasitology 90, 285304.
Ploeger, HW and Kloosterman, A 1993. Gastrointestinal nematode infections and weight gain in dairy replacement stock: first-year calves. Veterinary Parasitology 46, 223241.
Ploeger, HW, Kloosterman, A, Rietveld, FW, Berghen, P, Hilderson, H and Hollanders, W 1994. Quantitative estimation of the level of exposure to gastrointestinal nematode infection in first-year calves. Veterinary Parasitology 55, 287315.
Ravinet, N, Bareille, N, Lehebel, A, Ponnau, A, Chartier, C and Chauvin, A 2014. Change in milk production after treatment against gastrointestinal nematodes according to grazing history, parasitological and production-based indicators in adult dairy cows. Veterinary Parasitology 201, 95109.
Raynaud, JP, Bouchet, A, William, G, Leroy, JC, Naudin, B and Brunault, G 1976. Bovine ostertagiosis, a review. Analysis of types and syndromes found in France by post mortem examinations and total worm counts. Annales de Recherches Vétérinaires 7, 253280.
R Core Team 2013. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. from http://www.Rproject.org/.
SAS Technical Report R-101 1978. Tests of hypotheses in fixed-effects linear models copyright ©. SAS Institute Inc., Cary, NC, USA.
Shaw, DJ, Vercruysse, J, Claerebout, E, Agneessens, J and Dorny, P 1997. Gastrointestinal nematode infections of first-season grazing calves in Belgium: general patterns and the effect of chemoprophylaxis. Veterinary Parasitology 69, 103116.
Shaw, DJ, Vercruysse, J, Claerebout, E and Dorny, P 1998. Gastrointestinal nematode infections of first-grazing season calves in Western Europe: associations between parasitological, physiological and physical factors. Veterinary Parasitology 75, 133151.
Van Wyk, JA, Hoste, H, Kaplan, RM and Besier, RB 2006. Targeted selective treatment for worm management-How do we sell rational programs for farmers? Veterinary Parasitology 139, 336346.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed