Skip to main content Accessibility help
×
Home

Invited review: impact of specific nutrient interventions during mid-to-late gestation on physiological traits important for survival of multiple-born lambs

  • S. A. McCoard (a1), F. A. Sales (a2) and Q. L. Sciascia (a3)

Abstract

To improve production efficiency, the sheep meat industry has increased flock prolificacy. However, multiple-born lambs have lower birth weights, increased mortality and reduced growth rate compared with single-born lambs. Lamb mortality is a major issue for livestock farming globally and solutions are required to increase survival to realise the value of increased flock fecundity. Nutrition during gestation can influence maternal–foetal placental nutrient transfer and thus foetal growth and organ/tissue development, as well as improve postnatal productivity. This review covers the challenges and opportunities associated with increased prolificacy, highlights gaps in our knowledge and identifies some opportunities for how targeted intervention with specific nutrients during mid-to-late pregnancy may influence lamb survival and productivity with a specific focus on pasture-based systems. This time frame was selected as intervention strategies in short-time windows post-pregnancy scanning and before lambing to improve lamb survival in high-risk groups (e.g. triplets) are likely to be the most practical and economically feasible options for pasture-based extensive farming systems.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Invited review: impact of specific nutrient interventions during mid-to-late gestation on physiological traits important for survival of multiple-born lambs
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Invited review: impact of specific nutrient interventions during mid-to-late gestation on physiological traits important for survival of multiple-born lambs
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Invited review: impact of specific nutrient interventions during mid-to-late gestation on physiological traits important for survival of multiple-born lambs
      Available formats
      ×

Copyright

Corresponding author

References

Hide All
Alexander, G 1978. Quantitative development of adipose tissue in foetal sheep. Australian Journal of Biological Sciences 31, 489504.
Alexander, G and Williams, D 1968. Shivering and non‐shivering thermogenesis during summit metabolism in young lambs. The Journal of Physiology 198, 251276.
Amer, PR, McEwan, JC, Dodds, KG and Davis, GH 1999. Economic values for ewe prolificacy and lamb survival in New Zealand sheep. Livestock Production Science 58, 7590.
Andrewartha, KA, Caple, LW, Davies, WD and MacDonald, JW 1980. Observations on serum thyroxine concentrations in lambs and ewes to assess iodine nutrition. Australian Veterinary Journal 56, 1821.
Arroyo, JA, Brown, LD and Galan, HL 2009. Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction. American Journal of Obstetrics and Gynecology 201, 616. e1e7.
Ashworth, CJ, Dwyer, CM, McIlvaney, K, Werkman, M and Rooke, JA 2011. Breed differences in fetal and placental development and feto-maternal amino acid status following nutrient restriction during early and mid pregnancy in Scottish Blackface and Suffolk sheep. Reproduction, Fertility and Development 23, 10241033.
Boland, TM, Callan, JJ, Brophy, PO, Quinn, PJ and Crosby, TF 2006. Lamb serum vitamin E and immunoglobulin G concentrations in response to various maternal mineral and iodine supplementation regimens. Animal Science 82, 319325.
Boland, TM, Hayes, L, Sweeney, T, Callan, JJ, Baird, AW, Keely, S and Crosby, TF 2008. The effects of cobalt and iodine supplementation of the pregnant ewe diet on immunoglobulin G, vitamin E, T3 and T4 levels in the progeny. Animal 2, 197206.
Brown, LD and Hay, WW 2006. Effect of hyperinsulinemia on amino acid utilization and oxidation independent of glucose metabolism in the ovie fetus. American Journal of Physiology – Endocrinology and Metabolism 291, E1333E1340.
Brown, LD, Rozance, PJ, Thorn, SR, Friedman, JE and Hay, WW 2012. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. American Journal of Physiology – Endocrinology and Metabolism 303, E352E364.
Capobianco, E, Ramirez, VI, Fornes, D, Powell, TL, Jansson, PT and Jawerbaum, A 2015. Activation of mTOR signaling and increased nitric oxide metabolism in the placenta of rats with gestational diabetes. Placenta 36, 516.
Capper, JL, Wildinson, RG, Kasapidou, E, Pattinson, SE, Mackenzie, AM and Sinclair, LA 2005. The effect of dietary vitamin E and fatty acid supplementation of pregnant and lactating ewes on placental and mammary transfer of vitamin E to the lamb. The British Journal of Nutrition 93, 549557.
Capper, JL, Wilkinson, RG, Mackenzie, AM and Sinclair, LA 2006. Polyunsaturated fatty acid supplementation during pregnancy alters neonatal behaviour in sheep. The Journal of Nutrition 136, 397403.
Chen, CY, Carstens, GE, Gilbert, CD, Theis, CM, Archibeque, SL, Kurz, MW, Slay, LJ and Smith, SB 2007. Dietary supplementation of high levels of saturated and monounsaturated fatty acids to ewes during late gestation reduces thermogenesis in newborn lambs by depressing fatty acid oxidation in perirenal brown adipose tissue. The Journal of Nutrition 137, 4348.
Dalton, DC, Knight, TW and Johnson, DL 1980. Lamb survival in sheep breeds on New Zealand hill country. New Zealand Journal of Agricultural Research 23, 167173.
Daniels, JT, Hatfield, PG, Burgess, DE, Kott, RW and Bowman, JG 2000. Evaluation of ewe and lamb immune response when ewes were supplemented with vitamin E. Journal of Animal Science 78, 27312736.
De Boo, HA, van Sijl, PL, Smith, DEC, Kuik, W, Lafeber, HN and Harding, JE 2005. Arginine and mixed amino acids increase protein accretion in the growth restricted and normal ovine fetus by different mechanisms. Pediatric Research 85, 15751583.
Donald, GE, Langlands, JP, Bowles, JE and Smith, AJ 1994. Subclinical selenium insufficiency. 6. Thermoregulatory ability of perinatal lambs born to ewes supplemented with selenium and iodine. Australian Journal of Experimental Agriculture 34, 1924.
Dønnema, I, Randbya, AT, Hektoenb, L, Avdemc, F, Meling, S, Våge, ÅØ, Ådnøya, T, Steinheima, G and Waage, S 2015. Effect of vitamin E supplementation to ewes in late pregnancy on the rate of stillborn lambs. Small Ruminant Research 125, 154162.
Dwyer, CM 2007. The welfare of the neonatal lamb. Small Ruminant Research 76, 3141.
Dwyer, CM, Conington, J, Corbiere, F, Holmoy, IH, Muri, K, Nowak, R, Rooke, J, Viopond, J and Gautier, J-M 2016. Invited review: improving neonatal survival in small ruminants: science into practice. Animal 10, 449459.
Dwyer, CM and Morgan, CA 2006. Maintenance of body temperature in the neonatal lamb: effects of breed, birth weight, and litter size. Journal of Animal Science 84, 10931101.
Ergaz, Z, Avgil, M and Ornoy, A 2005. Intrauterine growth restriction – etiology and consequences: what do we know about the human situation and experimental animal models? Reproductive Toxicology 20, 301322.
Everett-Hincks, J and Dodds, K 2008. Management of maternal-offspring behavior to improve lamb survival in easy care sheep systems. Journal of Animal Science 86, E259E270.
Everett-Hincks, J, Lopez-Villalobos, N, Blair, H and Stafford, K 2005. The effect of ewe maternal behaviour score on lamb and litter survival. Livestock Production Science 93, 5161.
Fleming, T, Velazquez, M, Eckert, J, Lucas, E and Watkins, A 2012. Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring. Animal Reproduction Science 130, 193197.
Ford, S 2000. Cotyledonary placenta. In Encyclopedia of Reproduction (ed. J Neill and E Knobil), pp. 730738. Academic Press, San Diego, CA, USA.
Fowden, A, Ward, J, Wooding, F, Forhead, A and Constancia, M 2006. Programming placental nutrient transport capacity. The Journal of Physiology 572, 515.
Gilsanz, V, Chung, SA, Jackson, H, Dorey, FJ and Hu, HH 2011. Functional brown adipose tissue is related to muscle volume in children and adolescents. Journal of Pediatrics 158, 722726.
Gootwine, E, Spencer, TE and Bazer, FW 2007. Litter-size-dependent intrauterine growth restriction in sheep. Animal 1, 547564.
Grace, ND and Knowles, SO 2010. Iodine. In Managing mineral deficiencies in grazing livestock (ed. ND Grace, SO Knowles and AR Sykes), pp. 95105. New Zealand Society of Animal Production, Hamilton, New Zealand.
Grace, ND and Knowles, SO 2012. Trace element supplementation of livestock in New Zealand: meeting the challenges of free-range grazing systems. Veterinary Medicine International 2012, 1–8.
Greenwood, PL, Hunt, AS, Slepetis, RM, Finnerty, KD, Alston, C, Beermann, DH and Bell, AW 2002. Effects of birth weight and postnatal nutrition on neonatal sheep: III. Regulation of energy metabolism. Journal of Animal Science 80, 28502861.
Hammer, CJ, Thorson, JF, Meyer, AM, Redmer, DA, Luther, JS, Neville, TL, Reed, JJ, Reynolds, LP, Caton, JS and Vonnahme, KA 2011. Effects of maternal selenium supply and plane of nutrition during gestation on passive transfer of immunity and health in neonatal lambs. Journal of Animal Science 89, 36903698.
Hinch, GN and Brien, F 2014. Lamb survival in Australian flocks: a review. Animal Production Science 54, 656666.
Hodgson, J, Cameron, K, Clark, D, Condron, I, Fraser, T, Hedley, M, Holmes, C, Kemp, P, Lucas, R, Moot, D, Morris, S, Nicholas, P, Shadbolt, N, Sheath, G, Valentine, I, Waghorn, G and Woodfield, D 2005. New Zealand’s pastoral industries: efficient use of grassland resources. In Grasslands developments, opportunities, perspectives (ed. SG Reynolds and J Frame), pp. 181205. Science Publication, New Hampshire, USA.
Huber, JT 1988. Vitamins in ruminant nutrition. In The ruminant animal: digestive physiology and nutrition (ed. DC Church), pp. 313325. Prentice Hall, Englewood Cliffs, NJ, USA.
Ito, N, Ruegg, UT, Kudo, A, Miyagoe-Suzuki, Y and Takeda, S 2013. Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy. Nature Medicine 19, 101106.
Jansson, T and Powell, TL 2006. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? – a review. Placenta 27 (suppl. A), 91–97.
Kajimura, S, Seale, P and Spiegelman, BM 2010. Transcriptional control of brown fat development. Cell Metabolism 11, 257262.
Keithly, JI, Kott, RW, Berardinelli, JD, Moreaux, S and Hatfield, PG 2011. Thermogenesis, blood metabolites and hormones, and growth of lambs born to ewes supplemented with algae-derived docosahexanenoic acid. Journal of Animal Science 89, 43054313.
Kenyon, P 2008. A review of in-utero environmental effects on sheep production. Proceedings of the New Zealand Society of Animal Production 68, 142155.
Kenyon, PR and Blair, HT 2014. Foetal programming in sheep – effects on production. Small Ruminant Research 118, 1630.
Kerslake, JI, Kenyon, PR, Stafford, KJ, Morris, ST and Morel, PCH. 2010. Can maternal iodine supplementation improve twin- and triplet-born lamb plasma thyroid hormone concentrations and thermoregulation capabilities in the first 24-36 h of life? Journal of Agricultural Science 148, 453463.
Kim, J-Y, Burghardt, RC, Wu, G, Johnson, GA, Spencer, TE and Bazer, FW 2011. Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines. Biology of Reproduction 84, 7078.
Kivimae, A and Carpena, C 1973. The level of vitamin E content in some conventional feeding stuffs and the effects of genetic ariety, harvesting, processing and storage. Acta Agriculture Scandanavia 19 (suppl.), 161168.
Knowles, SO and Grace, ND 2015. Serum total iodine concentrations in pasture-fed pregnant ewes and newborn lambs challenged by iodine supplementation and goitrogenic kale. Journal of Animal Science 93, 425432.
Kwon, H, Ford, SP, Bazer, FW, Spencer, TE, Nathanielsz, PW, Nijland, MJ, Hess, BW and Wu, G 2004. Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids. Biology of Reproduction 71, 901908.
Kwon, H, Spencer, TE, Bazer, FW and Wu, G 2003. Developmental changes of amino acids in ovine fetal fluids. Biology of Reproduction 68, 18131820.
Lammoglia, MA, Bellows, RA, Grings, EE and Bergman, JW 1999. Effects of prepartum supplementary fat and muscle hypertrophy genotype on cold tolerance in newborn calves. Journal of Animal Science 77, 22272233.
Lane, J, Jubb, T, Shephard, R, Webb-Ware, J and Fordyce, G 2015. Priority list of endemic diseases for the red meat industries. Meat and Livestock Australia Final Report B.AHE.0010, 20 March 2015, North Sydney, New South Wales, Australia.
Lassala, A, Bazer, FW, Cudd, TA, Datta, S, Keisler, DH, Satterfield, MC, Spencer, TE and Wu, G 2010. Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewes. The Journal of Nutrition 140, 12421248.
Lassala, A, Bazer, FW, Cudd, TA, Datta, S, Keisler, DH, Satterfield, MC, Spencer, TE and Wu, G 2011. Parenteral administration of L-arginine enhances fetal survival and growth in sheep carrying multiple fetuses. The Journal of Nutrition 141, 849855.
Liechty, EA, Boyle, DW, Moorehead, H, Auble, L and Denne, SC 1999. Aromatic amino acids are utilized and protein synthesis is stimulated during amino acid infusion in the ovine fetus. The Journal of Nutrition 129, 11611166.
McCoard, S, Henderson, HV, Knol, FW, Dowling, SK and Webster, JR 2014b. Infrared thermal imaging as a method to study thermogenesis in the neonatal lamb. Animal Production Science 54, 14971501.
McCoard, S, Sales, F, Wards, N, Sciascia, Q, Oliver, M, Koolaard, J and van der Linden, D 2013. Parenteral administration of twin-bearing ewes with L-arginine enhances the birth weight and brown fat stores in sheep. SpringerPlus 2, 684.
McCoard, S, Wards, N, Koolaard, J and Salerno, MS 2014a. The effect of maternal arginine supplementation on the development of the thermogenic program in the ovine fetus. Animal Production Science 54, 18431847.
McCoard, SA, McNabb, WC, Birtles, MJ, Harris, PM, McCutcheon, SN and Peterson, SW 2001. Immunohistochemical detection of myogenic cells in muscles of fetal and neonatal lambs. Cells Tissues Organs 169, 2133.
McCoard, SA, Peterson, SW, McNabb, WC, Harris, PM and McCutcheon, SN 1997. Maternal constraint influences muscle fibre development in fetal lambs. Reproduction, Fertility and Development 9, 675681.
McCoard, SA, Sales, FA and Sciascia, QL 2016. Amino acids in sheep production. Frontiers in Bioscience, Elite 8, 264288.
McGovern, FM, Magee, DA, Browne, JA, MacHugh, DE and Boland, TM 2015. Iodine supplementation of the pregnant dam alters intestinal gene expression and immunoglobulin uptake in the newborn lamb. Animal, https://doi.org/10-.1017/S1751731115002505
Meijer, AJ and Dubbelhuis, PF 2004. Amino acid signalling and the integration of metabolism. Biochemical and Biophysical Research Communications 313, 397403.
Mellor, D 1983. Nutritional and placental determinants of foetal growth rate in sheep and consequences for the newborn lamb. The British Veterinary Journal 139, 307324.
Merrell, BC 1998. The effects of lamb survival rate of supplementing ewes with vitamin E during late pregnancy. Proceedings of Sheep Veterinary Society, Spring Meeting, Scarborough, Youdshire, UK, pp. 57–61.
Morel, PCH, Morris, ST and Kenyon, PR 2008. Effect of birthweight on survival in triplet-born lambs. Australian Journal of Experimental Agriculture 48, 984987.
Morris, ST and Kenyon, PR 2004. The effect of litter size and sward height on ewe and lamb performance. New Zealand Journal of Agricultural Research 48, 275286.
Morris, ST and Kenyon, PR 2014. Intensive sheep and beef production from pasture – a New Zealand perspective of conerns, opportunities and challenges. Meat Science 98, 330335.
Oliver, MH, Jaquiery, AL, Bloomfield, FH and Harding, JE 2007. The effects of maternal nutrition around the time of conception on the health of the offspring. Society of Reproduction and Fertility Supplement 64, 397410.
Pacheco, D, Treloar, BP, Kenyon, PR, Blair, HT and McCoard, S 2010. Brief communication: intracellular concentrations of free amino acids are reduced in skeletal muscle of late gestation twin compared to single fetuses. Proceedings of the New Zealand Society of Animal Production 70, 199201.
Pickard, RM, Beard, AJ, Seal, CJ and Edwards, SA 2005. Supplementation of ewe diets with algal biomass rich in docosahexaenoic acid for different time periods before lambing affects measures of lamb viability. Proceedings of the British Society of Animal Science, 89pp.
Pickard, RM, Beard, AP, Seal, CJ and Edwards, SA 2008. Neonatal lamb vigour is improved by feeding docosahexaenoic acid in the form of algal biomass during late gestation. Animal 2, 11861192.
Quirk, MF and Norton, BW 1987. The relationship between the cobalt nutrition of ewes and the vitamin B12 status of ewes and their lambs. Australian Journal of Agricultural Research 38, 10711082.
Rooke, JA, Dwyer, CM and Ashworth, CJ 2008. The potential for improving physiological, behavioural and immunological responses in the neonatal lamb by trace element and vitamin supplementation of the ewe. Animal 2, 514524.
Roos, S, Jansson, N, Palmberg, I, Säljö, K, Powell, TL and Jansson, T 2007. Mammalian target of rapamycin in the human placenta regulates leucine transport and is down‐regulated in restricted fetal growth. The Journal of Physiology 582, 449459.
Roos, S, Palmberg, I, Säljö, K, Powell, TL and Jansson, T 2005. Expression of placental mammalian target of rapamycin (mTOR) is altered in relation to fetal growth and mTOR regulates leucine transport. Placenta 26, A9.
Rose, MT, Wolf, BT and Haresign, W 2007. Effect of the level of iodine in the diet of pregnant ewes on the concentration of immunoglobulin G in the plasma of neonatal lambs following the consumption of colostrum. British Journal of Nutrition 97, 315320.
Rosenfeld, CR, Cox, BE, Roy, T and Magness, RR 1996. Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation. Journal of Clinical Investigation 98, 21582166.
Rowland, JP, Salman, MD, Kimberling, CV, Schweitzer, DJ and Keefe, TJ 1992. Epidemiologic factors involved in perinatal lamb mortality on four range sheep operations. American Journal of Veterinary Research 53, 262267.
Rumball, C, Harding, J, Oliver, M and Bloomfield, F 2008. Effects of twin pregnancy and periconceptional undernutrition on maternal metabolism, fetal growth and glucose – insulin axis function in ovine pregnancy. The Journal of Physiology 586, 13991411.
Sales, F 2014. Amino acids and skeletal muscle growth in lambs. PhD thesis, Massey University, Palmerston North, New Zealand.
Sales, F, Pacheco, D, Blair, H, Kenyon, P and McCoard, S 2013. Muscle free amino acid profiles are related to differences in skeletal muscle growth between single and twin ovine fetuses near term. SpringerPlus 2, 19.
Sales, F, Pacheco, D, Blair, H, Kenyon, P, Nicholas, G, Senna Salerno, M and McCoard, S 2014. Identification of amino acids associated with skeletal muscle growth in late gestation and at weaning in lambs of well-nourished sheep. Journal of Animal Science 92, 50415052.
Sargison, ND, West, DM and Clark, RG 1998. The effects of iodine deficiency on ewe fertility and perinatal lamb mortality. New Zealand Veterinary Journal 46, 7275.
Satterfield, M and Wu, G 2011. Growth and development of brown adipose tissue: significance and nutritional regulation. Frontiers in Bioscience 16, 15891608.
Satterfield, MC, Bazer, FW, Spencer, TE and Wu, G 2010. Sildenafil citrate treatment enhances amino acid availability in the conceptus and fetal growth in an ovine model of intrauterine growth restriction. Journal of Nutrition 140, 251258.
Scales, GH, Burton, RN and Moss, RA 1986. Lamb mortality, birth weight and nutrition in late pregnancy. New Zealand Journal of Agricultural Research 29, 7582.
Sciascia, Q, Pacheco, D, Bracegirdle, J, Berry, C, Kenyon, P, Blair, H, Senna Salerno, M, Nicholas, G and McCoard, S 2010. Brief communication: effects of restricted fetal nutrition in utero on mTOR signalling in ovine skeletal muscle. Proceedings of the New Zealand Society of Animal Production 70, 180182.
Seale, P, Bjork, B, Yang, W, Kajimura, S, Chin, S, Kuang, S, Scimè, A, Devarakonda, S, Conroe, HM, Erdjument-Bromage, H, Tempst, P, Rudnicki, MA, Beier, DR and Spiegelman, BM 2008. PRDM16 controls a brown fat/skeletal muscle switch. Nature 454, 961967.
Shorten, PR, O’Connell, AR, Demmers, KJ, Edwards, SJ, Cullen, NG and Juengel, JL 2013. Effect of age, weight, and sire on embryo and fetal survival in sheep. Journal of Animal Science 91, 46414653.
Stafford, KJ 2013. Welfare of sheep and goats. Animal welfare in New Zealand. Occasional publication no 16. New Zealand Society of Animal Production, Cambridge, New Zealand, pp. 56–71.
Stafford, KJ, Kenyon, PR, Morris, ST and West, DM 2007. The physical state and metabolic status of lambs of different birth rank soon after birth. Livestock Science 111, 1015.
Stoewsand, GS 1995. Bioactive organosulfur phytochemicals in Brassica oleracea vegetables – a review. Food Chemistry and Toxicology 33, 537543.
Symonds, ME 2013. Brown adipose tissue growth and development. Scientifica https://doi.org/10.1155/2013/305763
Symonds, ME and Lomax, MA 1992. Maternal and environmental influences on thermoregulation in the neonate. Proceedings of the Nutrition Society 51, 165172.
Symonds, ME, Sebert, SP and Budge, H 2010. Nutritional regulation of fetal growth and implications for productive life in ruminants. Animal 4, 10751083.
Symonds, ME, Sebert, S and Budge, H 2011. The obesity epidemic: from the environment to epigenetics – not simply a response to dietary manipulation in a thermoneutral environment. Frontiers in Genetics 2, 24.
Tan, XL, Yin, Y, Wu, Z, Liu, C, Tekwe, CD and Wu, G 2012. Regulatory roles for L-arginine in reducing white adipose tissue. Frontiers in Bioscience 17, 2237.
van der Linden, D, Sciascia, Q, Sales, F and McCoard, S 2013. Placental nutrient transport is affected by pregnancy rank in sheep. Journal of Animal Science 91, 644653.
van der Linden, D, Sciascia, Q, Sales, F, Wards, NJ, Oliver, MH and McCoard, SA 2015. Intravenous maternal L-arginine administration to twin-bearing ewes during late pregnancy enhances placental growth and development. Journal of Animal Science 93, 4917–4925.
Vonnahme, KA, Evoniuk, J, Johnson, ML, Borowicz, PP, Luther, JS, Pant, D, Redmer, DA, Reynolds, LP and Grazul-Bilska, AT 2008. Placental vascularity and growth factor expression in singleton, twin, and triplet pregnancies in the sheep. Endocrine 33, 5361.
Vonnahme, KA, Lemley, CO, Caton, JS and Meyer, AM 2015. Impacts of maternal nutrition on vascularity of nutrient transferring tissues during gestation and lactation. Nutrients 7, 34973523.
West, DM, Bruere, AN and Ridler, AI 2008. The sheep: health, disease and production, (3rd edition). Vet Learn Foundation, Wellington, New Zealand.
Wu, G, Bazer, FW, Burghardt, RC, Johnson, GA, Kim, SW, Li, XL, Satterfield, MC and Spencer, TE 2010. Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine production. Journal of Animal Science 88, E195E204.
Wu, G, Bazer, FW, Wallace, JM and Spencer, TE 2006. Board-invited review: intrauterine growth retardation: implications for the animal sciences. Journal of Animal Science 84, 23162337.
Yoon, M-S and Chen, J 2013. Distinct amino acid-sensing mTOR pathways regulate skeletal myogenesis. Molecular Biology of the Cell 24, 37543763.
Zhu, MJ, Ford, SP, Means, WJ, Hess, BW, Nathanielsz, PW and Du, M 2006. Maternal nutrient restriction affects properties of skeletal muscle in offspring. Journal of Physiology 575, 241250.

Keywords

Related content

Powered by UNSILO

Invited review: impact of specific nutrient interventions during mid-to-late gestation on physiological traits important for survival of multiple-born lambs

  • S. A. McCoard (a1), F. A. Sales (a2) and Q. L. Sciascia (a3)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.