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Effects of environmental pollutants on the reproduction and welfare of ruminants

  • S. M. Rhind (a1), N. P. Evans (a2), M. Bellingham (a2), R. M. Sharpe (a3), C. Cotinot (a4), B. Mandon-Pepin (a4), B. Loup (a4), K. D. Sinclair (a5), R. G. Lea (a5), P. Pocar (a6), B. Fischer (a7), E. van der Zalm (a7), K. Hart (a7), J.-S. Schmidt (a7), M. R. Amezaga (a8) and P. A. Fowler (a8)...

Abstract

Anthropogenic pollutants comprise a wide range of synthetic organic compounds and heavy metals, which are dispersed throughout the environment, usually at low concentrations. Exposure of ruminants, as for all other animals, is unavoidable and while the levels of exposure to most chemicals are usually too low to induce any physiological effects, combinations of pollutants can act additively or synergistically to perturb multiple physiological systems at all ages but particularly in the developing foetus. In sheep, organs affected by pollutant exposure include the ovary, testis, hypothalamus and pituitary gland and bone. Reported effects of exposure include changes in organ weight and gross structure, histology and gene and protein expression but these changes are not reflected in changes in reproductive performance under the conditions tested. These results illustrate the complexity of the effects of endocrine disrupting compounds on the reproductive axis, which make it difficult to extrapolate between, or even within, species. Effects of pollutant exposure on the thyroid gland, immune, cardiovascular and obesogenic systems have not been shown explicitly, in ruminants, but work on other species suggests that these systems can also be perturbed. It is concluded that exposure to a mixture of anthropogenic pollutants has significant effects on a wide variety of physiological systems, including the reproductive system. Although this physiological insult has not yet been shown to lead to a reduction in ruminant gross performance, there are already reports indicating that anthropogenic pollutant exposure can compromise several physiological systems and may pose a significant threat to both reproductive performance and welfare in the longer term. At present, many potential mechanisms of action for individual chemicals have been identified but knowledge of factors affecting the rate of tissue exposure and of the effects of combinations of chemicals on physiological systems is poor. Nevertheless, both are vital for the identification of risks to animal productivity and welfare.

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References

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Agras, K, Shiroyanagi, Y, Baskin, LS 2007. Progesterone receptors in the developing genital tubercle: implications for the endocrine disruptor hypothesis as the etiology of hypospadias. The Journal of Urology 178, 722727.
Ahel, M, Giger, W, Schaffner, C 1994. Behaviour of alkylphenol polyethoxylate surfactants in the aquatic environment-II. Occurrence and transformation in rivers. Water Research 28, 11431152.
Alonso-Magdalena, P, Laribi, O, Ropero, AB, Fuentes, E, Ripoli, C, Soria, B, Nadal, A 2005. Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic α-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans. Environmental Health Perspectives 113, 969977.
Amezaga, MR, Speers, CJB, Bellingham, M, Evans, NP, Mandon-Pepin, B, Cotinot, C, Sharpe, RM, Rhind, SM, Fowler, PA 2009. Sudden changes in exposure to environmental chemicals perturbs ovarian development. In Proceedings of the Society for Reproduction and Fertility, 7–9 January 2009, Edinburgh, UK, p. 37.
Amstislavsky, SY, Amstislavskaya, TG, Amstislavsky, VS, Tibeikina, MA, Osipov, KV, Eroschenko, VP 2006. Reproductive abnormalities in adult male mice following preimplantation exposures to estradiol or pesticide methoxychlor. Reproductive Toxicology 21, 154159.
Anas, MK, Suzuki, C, Yoshioka, K, Iwamura, S 2003. Effect of mono-(2-ethylhexyl) phthalate on bovine oocyte maturation in vitro. Reproductive Toxicology 17, 305310.
Anway, MD, Cupp, AS, Uzumcu, M, Skinner, MK 2005. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308, 14661469.
Anway, MD, Skinner, MK 2006. Epigenetic transgenerational actions of endocrine disruptors. Endocrinology 147, S43S49.
Barnett, KR, Tomic, D, Gupta, RK, Babus, JK, Roby, KF, Terranova, PF 2007. The aryl hydrocarbon receptor is required for normal gonadotropin responsiveness in the mouse ovary. Toxicology and Applied Pharmacology 223, 6672.
Beard, AP, Bartelewski, PM, Chandolia, RK, Honaramooz, A, Rawlings, NC 1999. Reproductive and endocrine function in rams exposed to the organochlorine pesticides lindane and pentachlorophenol from conception. Journal of Reproduction and Fertility 115, 303314.
Bellingham, M, Fowler, PA, Amezaga, MR, Rhind, SM, Cotinot, C, Mandon-Pepin, B, Sharpe, RM, Kyle, CE, Evans, NP 2009. Exposure to environmental endocrine disrupting compounds in sewage sludge: effects on the KiSS-1/GPR54 system in ovine hypothalamus and pituitary gland. Environmental Health Perspectives 117, 15561562.
Bemis, JC, Seegal, RF 1999. Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro. Environmental Health Perspectives 107, 879885.
Bøgh, IB, Christensen, P, Dantzer, V, Groot, M, Thøfner, ICN, Rasmussen, RK, Schmidt, M, Greve, T 2001. Endocrine disrupting compounds: effect of octylphenol on reproduction over three generations. Theriogenology 55, 131150.
Bostrom, CE, Gerde, P, Hanberg, A, Jernstrom, B, Johansson, C, Kyrklund, T, Rannug, A, Törnqvist, M, Victorin, K, Westerholm, R 2002. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environmental Health Perspectives 110 (suppl. 3), 451488.
Brevini, TAL, Vassena, R, Paffoni, A, Francisci, C, Fascio, U, Gandolfi, F 2004. Exposure of pig oocytes to PCBs during in vitro maturation: effects on developmental competence, cytoplasmic remodelling and communications with cumulus cells. European Journal of Histochemistry 48, 347356.
Brevini, TAL, Cillo, F, Antonini, S, Gandolfi, F 2005. Effects of endocrine disrupters on the oocytes and embryos of farm animals. Reproduction in Domestic Animals 40, 291299.
Brooke, DN, Nielsen, IR, Dobson, S, Howe, PD 1991. Environmental hazard assessment: di-(2-ethylhexyl) phthalate. Toxic Substances, Division, Directorate for Air Climate and Toxic Substances Department of the Environment, Watford, England.
Brotons, JA, Olea-Serrano, MF, Villalobos, M, Pedraza, V, Olea, N 1995. Xenoestrogens released from lacquer coatings in food cans. Environmental Health Perspectives 103, 608612.
Christiansen, S, Scholze, M, Axelstad, M, Boberg, J, Kortenkamp, A, Hass, U 2008. Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat. International Journal of Andrology 31, 241248.
Clausen, I, Kietz, S, Fischer, B 2005. Lineage-specific effects of polychlorinated biphenyls (PCB) on gene expression in the rabbit blastocyst. Reproductive Toxicology 20, 4756.
Colborn, T, Vom Saal, AM, Soto, AM 1993. Developmental effects of endocrine disrupting chemicals in wildlife and human. Environmental Health Perspectives 101, 378384.
Commission of the European Communities 1994. Directorate Generale XI, Waste Management – Sewage Sludge, Part I. Survey of Sludge Production, Treatment, Quality and Disposal in the European Union. EU Commission, Brussels, Belgium.
Crofton, KM, Craft, ES, Hedge, JM, Gennings, C, Simmons, JE, Carchman, RA, Carter, WH, deVito, MJ 2005. Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism. Environmental Health Perspectives 113, 15491554.
Davey, JC, Bodwell, JE, Gosse, JA, Hamilton, JW 2007. Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicological Sciences 98, 7586.
De Swart, RL, Ross, PS, Timmerman, HH, Vos, HW, Reijnders, PJH, Vos, JG, Osterhaus, ADME 1995. Impaired cellular immune response in harbour seals (Phoca vitulina) feeding on environmentally contaminated herring. Clinical and Experimental Immunology 101, 480486.
Detmar, J, Rabaqlino, T, Taniuchi, Y, Oh, J, Acton, BM, Benito, A, Nunez, G, Juriscova, A 2006. Embryonic loss due to exposure to polycyclic aromatic hydrocarbons is mediated by Bax. Apoptosis 11, 14131425.
Dietert, RR, Piepenbrink, S 2006. Perinatal immunotoxicity: why adult exposure assessment fails to predict risk. Environmental Health Perspectives 114, 477483.
Duarte-Davidson, R, Jones, KC 1996. Screening the environmental fate of organic contaminants in sewage sludge applied to agricultural soils: II the potential for transfers to plants and grazing animals. The Science of the Total Environment 185, 5970.
Edwards, TM, Miller, HD, Guillette, LJ 2006. Water quality influences reproduction in female mosquitofish (Gambusia holbrooki) from eight Florida springs. Environmental Health Perspectives 114 (suppl.), 6975.
Edwards, TM, Myers, JP 2007. Environmental exposures and gene regulation in disease etiology. Environmental Health Perspectives 115, 12641270.
Ema, M, Fujii, S, Ikka, T, Matsumoto, M, Hirose, A, Kamata, E 2007. Early pregnancy failure induced by dibutyltin dichloride in mice. Environmental Toxicology 22, 4452.
Erenberg, A, Omori, K, Menkes, JH, Oh, W, Fisher, DA 1974. Growth and development of the thyroidectomized ovine fetus. Pediatric Research 8, 783789.
Erhard, HW, Rhind, SM 2004. Prenatal and postnatal exposure to environmental pollutants in sewage sludge alters emotional reactivity and exploratory behaviour in sheep. The Science of the Total Environment 332, 101108.
Eriksson, P, Jakobsson, E, Fredriksson, A 2001. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment. Environmental Health Perspectives 109, 903908.
Evans, NP, North, T, Dye, S, Sweeney, T 2004. Differential effects of the endocrine-disrupting compounds bisphenol-A and octylphenol on gonadotrophin secretion, in prepubertal ewe lambs. Domestic Animal Endocrinology 26, 6173.
Fenton, SE 2006. Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequences. Endocrinology 147, S18S24.
Forsdike, RA, Hardy, K, Bull, L, Stark, J, Webber, LJ, Stubbs, S, Robinson, JE, Franks, S 2007. Disordered follicle development in ovaries of prenatally androgenized ewes. Journal of Endocrinology 192, 421428.
Fowler, PA, Abramovich, DR, Haites, NE, Cash, P, Groome, NO, Al-Qahtani, A, Murray, TJ, Lea, RG 2007a. Human fetal testis Leydig cell disruption by exposure to the pesticide dieldrin at low concentrations. Human Reproduction 22, 29192927.
Fowler, PA, Gordon, KL, Thow, CA, Cash, P, Miller, DW, Lea, RG, Rhind, SM 2007b. Exposure to sewage sludge disrupts ewe mammogenesis. In Proceedings of the Society for Reproduction and Fertility, 15–18 April 2007, York, UK, p. 75.
Fowler, PA, Dorà, NJ, McFerran, H, Amezaga, MR, Miller, DW, Lea, RG, Cash, P, McNeilly, AS, Evans, NP, Cotinot, C, Sharpe, RM, Rhind, SM 2008. In utero exposure to low doses of environmental pollutants disrupts fetal ovarian development in sheep. Molecular Human Reproduction 14, 269280.
Fox, JE 2004. Chemical communication threatened by endocrine-disrupting compounds. Environmental Health Perspectives 112, 648653.
Fries, GF 1995. A review of the significance of animal food products as potential pathways of human exposures to dioxins. Journal of Animal Science 73, 16391650.
Fries, GF 1996. Ingestion of sludge applied organic chemicals by animals. The Science of the Total Environment 185, 93108.
Fries, GF, Marrow, GS 1977. Distribution of hexachlorobenzene residues in beef steers. Journal of Animal Science 45, 11601165.
Fries, GF, Cook, RM, Prewitt, LR 1978. Distribution of polybrominated biphenyl residues in the tissue of environmentally contaminated dairy cows. Journal of Dairy Science 61, 420425.
Fujiyoshi, PT, Michalek, JE, Matsumura, F 2006. Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in US air force veterans of the Vietnam War. Environmental Health Perspectives 114, 16771683.
Greenlee, AR, Ellis, TM, Berg, RL, Mercieca, MD 2005. Pregnancy outcomes for mouse preimplantation embryos exposed in vitro to the estrogenic pesticide o,p’-DDT. Reproductive Toxicology 20, 229238.
Grun, F, Watanabe, H, Zamanian, Z, Maeda, L, Arima, K, Cubacha, R, Gardiner, DM, Kanno, J, Iguchi, T, Blumberg, B 2006. Endocrine disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Molecular Endocrinology 20, 21412155.
Guerquin, MJ, Duquenne, C, Coffigny, H, Rouiller-Fabre, V, Lambrot, R, Bakalska, M, Frydman, R, Habert, R, Livera, G 2009. Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation. Human Reproduction 24, 670678.
Guillette, LJ 2006. Endocrine disrupting compounds – beyond the dogma. Environmental Health Perspectives 114 (suppl. 1), 912.
Guillette, LJ, Edwards, T 2005. Is nitrate an ecologically relevant endocrine disruptor in vertebrates? Integrative and Comparative Biology 45, 1927.
Hanlon, PR, Ganem, LG, Cho, YC, Yamamoto, M, Jefcoate, CR 2003. AhR- and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-gamma1 expression and subsequent adipocyte differentiation. Toxicology and Applied Pharmacology 189, 1127.
Hanlon, PR, Cimafranca, MA, Liu, X, Cho, YC, Jefcoate, CR 2005. Microarray analysis of early adipogenesis in C3H10T1/2 cells: cooperative inhibitory effects of growth factors and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology 207, 3958.
Hansen, L 1998. Stepping backward to improve assessment of PCB congener toxicities. Environmental Health Perspectives 106, 171189.
Hausburg, MA, Dekrey, GK, Salmen, JJ, Palic, MR, Gardiner, CS 2005. Effects of paraquat on development of preimplantation embryos in vivo and in vitro. Reproductive Toxicology 20, 239246.
Hauser, R, Williams, P, Altshul, L, Calafat, AM 2005. Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm count. Environmental Health Perspectives 113, 425430.
Heltsley, R, Cope, WG, Bringolf, R, Eads, C, Shea, D 2006. Prozac elicits spawning in native freshwater mussels. Poster presented at the 232nd Meeting of the American Chemistry Society. American Chemical Society, Washington, DC.
Hirshfield, AN 1991. Development of follicles in the mammalian ovary. International Review of Cytology 124, 43101.
Hong, S, Candelone, J-P, Patterson, CC, Boutron, CF 1996. History of ancient copper smelting pollution during Roman and medieval times recorded in Greenland ice. Science 272, 246249.
Hotchkiss, AK, Rider, CV, Blystone, CR, Wilson, VS, Hartig, PC, Ankley, GT, Foster, PM, Gray, CL, Gray, LE 2008. Fifteen years after ‘Wingspread’ – environmental endocrine disruptors and human and wildlife health: where are we today and where we need to go. Toxicological Sciences 105, 235259.
Hoyer, PB 2005. Damage to ovarian development and function. Cell and Tissue Research 322, 99106.
Huang, J-C 2008. The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos. PPAR Research, doi:10.1155/2008/732303.
Humblet, O, Birnbaum, L, Rimm, E, Mittleman, MA, Hauser, R 2008. Dioxins and cardiovascular disease mortality. Environmental Health Perspectives 116, 14431448.
Hunt, PA, Koehler, KE, Susiarjo, M, Hodges, CA, Ilagan, A, Voigt, RC, Thomas, S, Thomas, BF, Hassold, TJ 2003. Bisphenol A exposure causes meiotic aneuploidy in the female mouse. Current Biology 13, 546553.
Hussein, HS, Brasel, JM 2001. Toxicity, metabolism and impact of mycotoxins on humans and animals. Toxicology 167, 101134.
Hutchison, GR, Scott, HM, Walker, M, McKinnell, C, Mahood, IK, Ferrara, D, Sharpe, RM 2008. Sertoli cell development and function in an animal model of testicular dysgenesis syndrome. Biology of Reproduction 78, 352360.
Hutt, KJ, Shi, Z, Albertini, DF, Petroff, BK 2008. The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo. BMC Developmental Biology 8, 1, 10.1186/1471-213X-8-1.
Institute for Environment and Health (IEH) 1999. IEH assessment on the ecological significance of endocrine disruption: effects on reproductive function and consequences for natural populations (assessment A4). MRC Institute for Environment and Health, Leicester, UK.
Inoue, T, Kaibara, M, Sakurai-Yamashita, Y, Kawano, M, Ishimaru, T, Taniyama, K 2004. Increases in serum nitrite and nitrate of a few-fold adversely affect the outcome of pregnancy in rats. Journal of Pharmacological Sciences 95, 228233.
IPCS 2002. Global Assessment of the State-of-the-Science of Endocrine Disruptors (ed. T Damstra, S Barlow, A Bergman, R Kavlock and G Van Der Kraak), from http://ehp.niehs.nih.gov/who/preface.pdf
Jekat, FW, Meisel, ML, Eckard, R, Winterhoff, H 1994. Effects of pentachlorophenol (PCP) on the pituitary and thyroidal hormone regulation in the rat. Toxicology Letters 71, 925.
Katoh, K, Matsuda, A, Ishigami, A, Yonekura, S, Ishiwata, H, Chen, C, Obara, Y 2004. Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells. Cell Biology International 28, 463469.
Kelly, KE 1995. Health effects of hazardous waste incineration – more of the rest of the story. In Proceedings of the International Incineration Conference, 8–12 May 1995, Seattle, WA. Retrieved 19 March 2010 from http://www.deltatoxicology.com/pdf/5cases.pdf
Kietz, S, Fischer, B 2003. Polychlorinated biphenyls affect gene expression in the rabbit preimplantation embryo. Molecular Reproduction and Development 64, 251260.
Kirigaya, A, Hayashi, S, Iguchi, T, Sato, T 2006. Developmental effects of ethinylestradiol on reproductive organs of female mice. In Vivo 20, 867873.
Korrick, SA, Bellinger, DG 2007. Persistent organic pollutants and childhood learning and behavioural disorders. Journal of Epidemiology and Community Health 61, 564565.
Kortenkamp, A 2007. Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals. Environmental Health Perspectives 115, 98105.
Krogenaes, AK, Tauboll, E, Stien, A, Oskam, IC, Lyche, JL, Dahl, E, Thomassen, RF, Sweeney, T, Ropstad, E 2008. Valproate affects reproductive endocrine function, testis diameter and some semen variables in non-epileptic adolescent goat bucks. Theriogenology 70, 1526.
Lanphear, BP, Hornung, R, Khoury, J, Yolton, K, Baghurst, P, Bellinger, DC, Canfield, RL, Dietrich, KN, Bornschein, R, Greene, T, Rothenberg, SJ, Needleman, HL, Schnaas, L, Wasserman, G, Graziano, J, Roberts, R 2005. Low level environmental lead exposure and children’s intellectual function: an international pooled analysis. Environmental Health Perspectives 113, 894899.
Li, E 2002. Chromatin modification and epigenetic reprogramming in mammalian development. Nature Reviews Genetics 3, 662673.
Li, B, Liu, HY, Dai, LJ, Lu, JC, Yang, ZM, Huang, L 2006. The early embryo loss caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin may be related to the accumulation of this compound in the uterus. Reproductive Toxicology 21, 301306.
Lind, PM, Milnes, MR, Lundberg, R, Bermudez, D, Orberg, J, Guillette, LJ 2004a. Abnormal bone composition in female juvenile American alligators from a pesticide-polluted lake (Lake Apopka, Florida). Environmental Health Perspectives 112, 359362.
Lind, PM, Orberg, J, Edlund, U-B, Sjoblom, L, Lind, L 2004b. The dioxin-like pollutant PCB 126 (3,3′,4,4′,5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats. Toxicology Letters 150, 293299.
Lind, PM, Gustavsson, M, Hermsen, S, Larsson, S, Kyle, CE, Örberg, J, Rhind, SM 2009. Exposure to sewage sludge disrupts bone tissue homeostasis in sheep. Science of the Total Environment 407, 22002208.
Lovekamp-Swan, T, Davis, BJ 2003. Mechanisms of phthalate ester toxicity in the female reproductive system. Environmental Health Perspectives 111, 139145.
Lundberg, R, Lyche, JL, Ropstad, E, Aleksandersen, M, Ronn, M, Skaare, JU, Larsson, S, Örberg, J, Lind, PM 2006. Perinatal exposure to PCB 153, but not PCB 126, alters bone tissue composition in female goat offspring. Toxicology 228, 3340.
Lundberg, R, Fox, GA, Wejheden, C, Lind, L, Larsson, S, Örberg, J, Lind, PM 2008. Altered bone properties in herring gulls (Larus Argentatus) residing in the Great Lakes in the early 1990s. Journal of Toxicology and Environmental Health, Part A 71, 19.
Lyche, JL, Oskam, IC, Skaare, JU, Reksen, O, Sweeney, T, Dahl, E, Farstad, W, Ropstad, E 2004. Effects of gestational and lactational exposure to low doses of PCBs 126 and 153 on anterior pituitary and gonadal hormones and on puberty in female goats. Reproductive Toxicology 19, 8795.
Makrigiannakis, A, Minas, V, Kalantaridou, SN, Chrousos, GP 2006. Hormonal and cytokine regulation of early implantation. Trends in Endocrinology and Metabolism 17, 178185.
Mandon-Pepin, B, Loup, B, Poumerol, E, Fowler, PA, Amezaga, MR, Sharpe, RM, Evans, NP, Bellingham, M, Rhind, SM, Cotinot, C 2009. Consequences of in utero exposure to environmental chemicals on ovary development in sheep. In Poster presented at the 5th Copenhagen Workshop on Endocrine Disruptors, 20–22 May, 2009, Copenhagen, Denmark, 1 pp.
Martineau, D, Lagace, A, Beland, P, Higgins, R, Armstrong, D, Shugart, LR 1988. Pathology of stranded beluga whales (Dephinapterus leucas) from the St. Lawrence estuary, Quebec, Canada. Journal of Comparative Pathology 98, 287311.
McMillan, BJ, Bradfield, CA 2007. The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Molecular Pharmacology 72, 487498.
McNatty, KP, Heath, DA, Lundy, T, Fidler, AE, Quirke, L, O’Connell, A, Smith, P, Groome, N, Tisdall, DJ 1999. Control of early ovarian follicular development. Journal of Reproduction and Fertility Supplement 54, 316.
Meador, JP, McCaarty, LS, Escher, BI, Adams, WJ 2008. The tissue-residue approach for toxicity assessment: concepts, issues, applications, and recommendations. Journal of Environmental Monitoring 10, 14861498.
Meharg, AA, Deacon, C, Edwards, KJ, Donaldson, M, Davidson, DA, Spring, C, Scrimgeour, CM, Feldmann, J, Rabb, A 2006. Ancient manuring practices pollute arable soils at St Kilda World Heritage Site, Scottish North Atlantic. Chemosphere 64, 18181828.
Meijer, GAL, de Bree, JA, Wagenaar, JA, Spoelstra, SF 1999. Sewerage overflows put production and fertility of dairy cows at risk. Journal of Environmental Quality 28, 13811383.
Minervini, F, Dell’Aquila, ME, Maritato, F, Minoia, P, Visconti, A 2001. Toxic effects of the mycotoxin zearalenone and its derivatives on in vitro maturation of bovine oocytes and 17 -estradiol levels in mural granulosa cell cultures. Toxicology In Vitro 15, 489495.
Moral, R, Wang, R, Russo, IH, Lamartiniere, CA, Pereira, J, Russo, J 2008. Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature. Journal of Endocrinology 196, 101112.
Morgan, HD, Santos, F, Green, K, Dean, W, Reik, W 2005. Epigenetic reprogramming in mammals. Human Molecular Genetics 14, R47R58.
Nakanishi, T 2008. Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor. The Journal of Toxicological Sciences 33, 269276.
Nandi, S, Gupta, PS, Selvaraju, S, Roy, SC, Ravindra, JP 2010. Effects of exposure to heavy metals on viability, maturation, fertilization, and embryonic development of buffalo (Bubalus bubalis) oocytes in vitro. Archives of Environmental Contamination and Toxicology 58, 194204.
Navarrete Santos, A, Ramin, N, Tonack, S, Fischer, B 2008. Cell lineage-specific signalling of insulin and insulin like growth factor (IGF) 1 in rabbit blastocysts. Endocrinology 149, 515524.
Navarrete Santos, A, Tonack, S, Kirstein, M, Kietz, S, Fischer, B 2004a. Two insulin-responsive glucose transporter isoforms and the insulin receptor are developmentally expressed in rabbit preimplantation embryos. Reproduction 128, 503516.
Navarrete Santos, A, Tonack, S, Kirstein, M, Pantaleon, M, Kaye, P, Fischer, B 2004b. Insulin acts via MAPK phosphorylation in rabbit blastocysts. Reproduction 128, 517526.
Nebert, DW 2005. Inter-individual susceptibility to environmental toxicants – a current assessment. Toxicology and Applied Pharmacology 207, S34S42.
Nikaido, Y, Yoshizawa, K, Danbara, N, Tsujita-Kyutoku, M, Yuri, T, Uehara, N, Tsubura, A 2004. Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring. Reproductive Toxicology 18, 803811.
Nimrod, AC, Benson, WH 1996. Environmental estrogenic effects of alkylphenol ethoxylates. Critical Reviews in Toxicology 26, 335364.
Nordstrom Joensen, U, Skakkebaek, NE, Jorgensen, N 2009. Is there a problem with male reproduction? Nature Clinical Practice – Endocrinology and Metabolism 5, 144145.
Norstrom, RJ 2002. Understanding bioaccumulation of POPs in food webs: chemical, biological, ecological and environmental considerations. Environmental Science and Pollution Research 9, 300303.
Office for National Statistics 2008. Cancer Statistics registrations: Registrations of cancer diagnosed in 2005, England. Series MB1 no. 36. National Statistics, London, UK.
Ohtake, F, Fujii-Kuriyama, Y, Shigeaki, K 2009. AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions. Biochemical Pharmacology 77, 474484.
Oskam, IC, Lyche, JL, Krogenaes, A, Thomassen, R, Skaare, JU, Wiger, R, Dahl, E, Sweeney, T, Stien, A, Ropstad, E 2005. Effects of long-term maternal exposure to low doses of PCB126 and PCB153 on the reproductive system and related hormones of young male goats. Reproduction 130, 731742.
Paul, C, Rhind, SM, Kyle, CE, Scott, H, McKinnell, C, Sharpe, RM 2005. Cellular and hormonal disruption of fetal testis development in sheep reared on pasture treated with sewage sludge. Environmental Health Perspectives 113, 15801587.
Payne, J, Rajapakse, N, Wilkins, M, Kortenkamp, A 2000. Prediction and assessment of the effects of four xenoestrogens. Environmental Health Perspectives 108, 983987.
Pocar, P, Augustin, R, Fischer, B 2004. Constitutive expression of CYP1A1 in bovine cumulus oocyte-complexes in vitro: mechanisms and biological implications. Endocrinology 145, 15941601.
Pocar, P, Augustin, R, Gandolfi, F, Fischer, B 2003. Toxic effects of in vitro exposure to p-tert-octylphenol on bovine oocyte maturation and developmental competence. Biology of Reproduction 69, 462468.
Pocar, P, Fischer, B, Klonisch, T, Hombach-Klonisch, S 2005a. Molecular interactions of the aryl hydrocarbon receptor and its biological and toxicological relevance for reproduction. Reproduction 129, 379389.
Pocar, P, Brevini, TA, Perazzoli, F, Cillo, F, Modina, S, Gandolfi, F 2001b. Cellular and molecular mechanisms mediating the effects of polychlorinated biphenyls on oocyte developmental competence in cattle. Molecular Reproduction and Development 60, 535541.
Pocar, P, Perazzoli, F, Luciano, AM, Gandolfi, F 2001a. In vitro reproductive toxicity of polychlorinated biphenyls: effects on oocyte maturation and developmental competence in cattle. Molecular Reproduction and Development 58, 411416.
Pocar, P, Nestler, D, Risch, M, Fischer, B 2005b. Apoptosis in bovine cumulus-oocyte complexes after exposure to polychlorinated biphenyl mixtures during in vitro maturation. Reproduction 130, 857868.
Rajapakse, N, Silva, E, Kortenkamp, A 2002. Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone action. Environmental Health Perspectives 110, 917921.
Rhind, SM 2002. Endocrine disrupting compounds and farm animals: their properties, actions and routes of exposure. Domestic Animal Endocrinology 23, 179187.
Rhind, SM 2005. Are endocrine disrupting compounds a threat to farm animal health, welfare and productivity? Reproduction in Domestic Animals 40, 282290.
Rhind, SM 2008. Endocrine disruptors and other food contaminating environmental pollutants as risk factors in animal reproduction. Reproduction in Domestic Animals 43 (suppl. 2), 1522.
Rhind, SM 2009. Anthropogenic pollutants – a threat to ecosystem sustainability and our survival? Philosophical Transactions of the Royal Society of London 364, 33913401.
Rhind, SM, Rae, MT, Brooks, AN 2001. Effects of nutrition and environmental factors on the fetal programming of the reproductive axis. Reproduction 122, 205214.
Rhind, SM, Kyle, CE, Telfer, G, Duff, EI, Smith, A 2005a. Alkyl phenols and diethylhexyl phthalate in tissues of sheep grazing pastures fertilised with sewage sludge or inorganic fertilizer. Environmental Health Perspectives 113, 447453.
Rhind, SM, Kyle, CE, Owen, J 2005b. Accumulation of potentially toxic metals in the liver tissue of sheep grazed on sewage sludge-treated pastures. Animal Science 81, 107113.
Rhind, SM, Kyle, CK, Mackie, C, Telfer, G 2007. Effects of exposure of ewes to sewage sludge-treated pasture on phthalate and alkyl phenol concentrations in their milk. The Science of the Total Environment 383, 7080.
Rhind, SM, Kyle, CE, Mackie, C, Telfer, G 2009. PCB and PBDE accumulation in adult and fetal sheep grazing sludge treated pastures. Journal of Environmental Monitoring 11, 14691476.
Robinson, J 2006. Prenatal programming of the female reproductive neuroendocrine system by androgens. Reproduction 132, 539547.
Rider, CV, Wilson, VS, Howdeshell, KL, Hotchkiss, AK, Furr, JR, Lambright, CR, Gray, LE Jr 2009. Cumulative effects of in utero administration of mixtures of “antiandrogens” on male rat reproductive development. Toxicologic Pathology 37, 100113.
Rüsse, I 1983. Oogenesis in cattle and sheep. Bibliotheca Anatomica 24, 7792.
Safe, SH 1990. Polychlorinated biphenyls (CBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds : environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Critical Reviews in Toxicology 21, 5188.
Santillo, D, Johnston, P 2006. Effect thresholds and ‘adequate control of risks. The fatal flaws in the EU Council’s position on authorisation within REACH. Environmental Science and Pollution Research 13, 425431.
Savabieasfahani, M, Kannan, K, Astapova, O, Evans, NP, Padmanabhan, V 2006. Developmental programming: differential effects of prenatal exposure to bisphenol-A or methoxychlor on reproductive function. Endocrinology 147, 59565966.
Sawyer, HR, Smith, P, Heath, DA, Juengel, JL, Wakefield, SJ, McNatty, KP 2002. Formation of ovarian follicles during fetal development in sheep. Biology of Reproduction 66, 11341150.
Scott, HM, Hutchison, GR, Jobling, MS, McKinnell, C, Drake, AJ, Sharpe, RM 2008. Relationship between androgen action in the ‘male programming window’, fetal Sertoli cell number and adult testis size in the rat. Endocrinology 149, 52805287.
Scott, HM, Hutchison, GR, Mahood, IK, Hallmark, N, Welsh, M, de Gendt, K, Verhoeven, G, O’Shaughnessy, PJ, Sharpe, RM 2007. Role of androgens in fetal testis development and dysgenesis. Endocrinology 148, 20272036.
Setchell, BP 1997. Sperm counts in semen of farm animals 1932–1995. International Journal of Andrology 20, 209214.
Sharpe, RM 1994. Regulation of spermatogenesis. In The Physiology of Reproduction (ed. E Knobil and JD Neill), 2nd edition, pp. 13631434. Raven Press, New York.
Sharpe, RM, Skakkebaek, NE 2003. Male reproductive disorders and the role of endocrine disruption: advances in understanding and identification of areas for future research. Pure and Applied Chemistry 75, 20232038.
Shi, ZD, Barrell, GK 1992. Requirement of thyroid function for the expression of seasonal reproductive and related changes in red deer (Cervus elaphus) stags. Journal of Reproduction and Fertility 94, 251259.
Sikka, SC, Naz, RK 1999. Endocrine disruptors and male fertility. In Endocrine disruptors. Effects on male and female reproductive systems (ed. RK Naz ), pp. 225246. CRC Press, London, UK.
Sinclair, KD, Allegrucci, C, Singh, R, Gardner, DS, Sebastian, S, Bispham, J, Thurston, A, Huntley, JF, Rees, WD, Maloney, CA, Lea, RG, Craigon, J, McEvoy, TG, Young, LE 2007. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proceedings of the National Academy of Sciences of the United States of America 104, 1935119356.
Skakkebaek, NE, Rajpert-De Meyts, E, Main, KM 2001. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Human Reproduction 16, 972978.
Skene, SA, Dewhurst, IC, Greenberg, M 1989. Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans: the risk to human health. A review. Human Toxicology 8, 173203.
Skinner, MK 2005. Regulation of primordial follicle assembly and development. Human Reproduction Update 11, 461471.
Smith, SR 1995. Organic pollutants. InAgricultural recycling of sewage sludge and the environment (ed. SR Smith), Chapter 10, pp. 207236. CAB International Publishing, Wallingford, UK.
Spurgeon, DJ, Hopkin, SP, Jones, DT 1994. The effects of cadmium, copper, lead and zinc on growth, reproduction and survival of the earthworm Eisenia fetida (Savigny): assessing the environmental impact of point-source metal contamination in terrestrial ecosytems. Environmental Pollution 84A, 123130.
Stahlhut, RW, van Wijngaarden, E, Dye, TD, Cook, S, Swan, SH 2007. Concentrations of urinary phthalate metabolites are associated with increased waist cicumference and insulin resistance in adult US males. Environmental Health Perspectives 115, 876882.
Steinberg, RM, Walker, DM, Juenger, TE, Woller, MJ, Gore, AC 2008. Effects of perinatal polychlorinated biphenyls on adult female rat reproduction: development, reproductive physiology, and second generation effects. Biology of Reproduction 78, 10911101.
Sugiyama, S, Shimada, N, Miyoshi, H, Yamauchi, K 2005. Detection of thyroid system-disrupting chemicals using in vitro and in vivo screening assays in Xenopus laevis. Toxicological Sciences 88, 367374.
Suk, WA, Olden, K, Yang, RSH 2002. Chemical mixtures research: significance and future perspectives. Environmental Health Perspectives 110 (suppl. 6), 891892.
Swan, SH, Elkin, EP, Fenster, L 2000. The question of declining sperm density revisited: an analysis of 101 studies published 1934–1996. Environmental Health Perspectives 108, 961966.
Swanson, RL, Bortman, U, O’Connor, P, Stanford, HM 2004. Science, policy and the management of sewage materials. The New York City experience. Marine Pollution Bulletin 49, 679687.
Swedenborg, E, Ruegg, J, Makela, S, Pongratz, I 2009. Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders. Journal of Molecular Endocrinology 43, 110.
Sweeney, T, Fox, J, Robertson, L, Kelly, G, Duffy, P, Lonergan, P, O’Doherty, J, Roche, JF, Evans, NP 2007. Postnatal exposure to octylphenol decreases semen quality in the adult ram. Theriogenology 67, 10681075.
Sweeney, T, Nicol, L, Roche, JF, Brooks, AN 2000. Maternal exposure to octylphenol suppresses ovine fetal follicle hormone secretion, testis size, and Sertoli cell number. Endocrinology 141, 26672673.
Thompson, J, Bannigan, J 2008. Cadmium: toxic effects on the reproductive system and the embryo. Reproductive Toxicology 25, 304315.
Tonack, S, Kind, K, Thompson, JG, Wobus, AM, Fischer, B, Navarrete Santos, A 2007. Dioxin affects glucose transport via the arylhydrocarbon receptor signal cascade in pluripotent embryonic carcinoma cells. Endocrinology 148, 59025912.
Toppari, J, Larsen, JC, Christiansen, P, Giwercman, A, Grandjean, P, Guillette, LJ, Jegou, B, Jensen, TK, Jouannet, P, Keiding, N, Leffers, H, McLachlan, JA, Meyer, O, Muller, J, Meyts, ER, Scheike, T, Sharpe, RM, Sumpter, J, Skakkebaek, NE 1996. Male reproductive health and environmental xenoestrogens. Environmental Health Perspectives 104 (suppl. 4), 741803.
Uzumcu, M, Zachow, R 2007. Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function. Reproductive Toxicology 23, 337352.
Villard, PH, Caverni, S, Baanannou, A, Khalil, A, Martin, PG, Penel, C, Pineau, T, Seree, E, Barra, Y 2007. PPARalpha transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects. Biochemical and Biophysical Research Communications 364, 896901.
Vreugdenhil, HJI, Slijper, FME, Mulder, PGH, Weisglas-Kuperus, N 2002. Effects of perinatal exposure to PCBs and dioxins on play behavior in Dutch children at school age. Environmental Health Perspectives 110, A593A598.
Welsh, M, Saunders, PTK, Fisken, M, Scott, HM, Hutchison, GR, Smith, LB, Sharpe, RM 2008. Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. Journal of Clinical Investigation 118, 14791490.
Wild, SR, Jones, KC 1992. Organic chemicals entering agricultural soils in sewage sludges: screening for their potential to transfer to crop plants and livestock. The Science of the Total Environment 119, 85119.
Wójtowicz, AK, Augustowska, K, Gregoraszczuk, EL 2007. The short- and long-term effects of two isomers of DDT and their metabolite DDE on hormone secretion and survival of human choriocarcinoma JEG-3 cells. Pharmacological Reports 59, 224232.
Wood, RI, Foster, DL 1998. Sexual differentiation of neuroendocrine function in sheep. Reviews of Reproduction 3, 130140.
Wright, C, Evans, ACO, Evans, NP, Duffy, P, Fox, J, Boland, MP, Roche, JF, Sweeney, T 2002. Effect of maternal exposure to the environmental estrogen, octyl phenol, during fetal and/or postnatal life on onset of puberty, endocrine status, and ovarian follicular dynamics in ewe lambs. Biology of Reproduction 67, 17341740.
Yunker, MB, Macdonald, RW, Vingarzan, R, Mitchell, RH, Goyette, D, Sylvestre, S 2002. PAHs in the Fraser River basin: a critical appraisal of PAH ratios as indicators of PAH source and composition. Organic Geochemistry 33, 489515.

Keywords

Effects of environmental pollutants on the reproduction and welfare of ruminants

  • S. M. Rhind (a1), N. P. Evans (a2), M. Bellingham (a2), R. M. Sharpe (a3), C. Cotinot (a4), B. Mandon-Pepin (a4), B. Loup (a4), K. D. Sinclair (a5), R. G. Lea (a5), P. Pocar (a6), B. Fischer (a7), E. van der Zalm (a7), K. Hart (a7), J.-S. Schmidt (a7), M. R. Amezaga (a8) and P. A. Fowler (a8)...

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