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Behavioural measures reflect pain-mitigating effects of meloxicam in combination with Tri-Solfen® in mulesed Merino lambs

  • L. Inglis (a1), S. Hancock (a1), M. Laurence (a1) and A. Thompson (a1)

Abstract

Flystrike costs the Australian industry $173 to 280 M per annum and 70% to 80% of Merino lambs are currently mulesed to reduce the risk of flystrike. To alleviate welfare concerns there has been widespread adoption of analgesics to mitigate the pain associated with mulesing. The objective of this experiment was to determine the effectiveness of Tri-Solfen® and meloxicam (Metacam® 20) at reducing pain-related behavioural responses to mulesing in Merino lambs. One hundred and forty Merino lambs were allocated to one of seven treatment groups: (1) non-mulesed (Control); (2) mulesed with no pain relief; (3) subcutaneous (s.c.) meloxicam administered 15 min before mulesing; (4) Tri-Solfen® administered at time of mulesing; (5) Tri-Solfen® and saline injection (s.c.) 15 min before mulesing; (6) Tri-Solfen® and meloxicam (s.c.) 15 min before mulesing; and (7) meloxicam (s.c.) at time the of mulesing. Behavioural responses such as standing, walking and lying were measured every 15 min for 6 h on the day of marking and for up to 2 h for 4 days thereafter. Standing (hunched v. normal) and walking (stiff v. normal) behaviours were then categorised into pain- and normal-related behaviours while lying remained in its own category. Mulesed lambs with no pain relief displayed significantly more pain-related behaviours than Control lambs during the 6 h post-mulesing (1.22 v. 0.22 out of a total score of 3; RSD=1.15). Lambs that received a combination of pain relief displayed significantly less pain-related behaviour than mulesed lambs with no pain relief on the day of mulesing (0.85 v. 1.22 out of a total score of 3; RSD=1.15). Administration of meloxicam or Tri-Solfen® on their own had minimal if any significant effect on pain-related behaviours on the day of mulesing. The results of this experiment support the use of pain-related behaviours to measure the efficacy of analgesics and the use of multimodal analgesia during mulesing of lambs.

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Chapman, R, Fell, L and Shutt, D 1994. A comparison of stress in surgically and non-surgically mulesed sheep. Australian Veterinary Journal 71, 243247.
Coetzee, JF, Mosher, R and Allen, PS 2009. Phatmacokentics of intraveous and oral Meloxicam in ruminant calves. Veterinary Therapeutics 10, 18.
Coetzee, H and Smith, R 2010. Recommendations for castration and dehorning of cattle. In Proceedings of the 43rd Annual Conference of the American Association of Bovine Practitioners, Albuquerque, NM, USA, 19–21 August 2010, pp. 40–45.
Colditz, I, Paull, D, Hervault, G, Aubriot, D and Lee, C 2011. Development of a lameness model in sheep for assessing efficacy of analgesics. Australian Veterinary Journal 89, 297304.
Davies, P, Bailey, PJ, Goldenberg, MM and Ford-Hutchinson, AW 1984. The role of arachidonic acid oxygenation products in pain and inflammation. Annual Review of Immunology 2, 335357.
Fell, L and Shutt, D 1989. Behavioural and hormonal responses to acute surgical stress in sheep. Applied Animal Behaviour Science 22, 283294.
Grant, C 2004. Behavioural responses of lambs to common painful husbandry procedures. Applied Animal Behaviour Science 87, 255273.
Keita, A, Pagot, E, Prunier, A and Guidarini, C 2010. Pre-emptive meloxicam for opst-operative analgesia in piglets undergoing surgical castration. Veterinary Anaesthesia and Analgesia 37, 367374.
Lane, J, Jubb, T, Shephard, R, Webb-Ware, J and Fordyce, G 2015. Priority list of endemic diseases for the red meat industries. Meat & Livestock Australia, Sydney, NSW, Australia.
Lee, C and Fisher, AD 2007. Welfare consequences of mulesing of sheep. Australian Veterinary Journal 85, 8993.
Lees, P, McKellar, Q, Foot, R and Gettinby, G 1998. Pharmacodynamics and pharmacokinetics of tolfenamicacid in ruminating calves: evaluation in models of acute inflammation. The Veterinary Journal 155, 275288.
Lomax, S, Sheil, M and Windsor, P 2008. Impact of topical anaesthesia on pain alleviation and wound healing in lambs after mulesing. Australian Veterinary Journal 86, 159168.
Lomax, S, Sheil, M and Windsor, P 2013. Duration of action of a topical anaesthetic formulation for pain management of mulesing in sheep. Australian Veterinary Journal 91, 160167.
Mathews, KA 2002. Non‐steroidal anti‐inflammatory analgesics: a review of current practice. Journal of Veterinary Emergency and Critical Care 12, 8997.
Mellor, D and Murray, L 1989. Effects of tail docking and castration on behaviour and plasma cortisol concentrations in young lambs. Research of Veterinary Science 46, 387391.
Molony, V and Kent, J 1997. Assessment of acute pain in farm animals using beahvioural and physiological measurements. Journal of Animal Science 75, 266272.
Molony, V, Kent, J and McKendrick, I 2002. Validation of a method for assessment of an acute pain in lambs. Applied Animal Behaviour Science 76, 215238.
Paull, D, Lee, C, Atkinson, S and Fisher, A 2008. Effects of meloxicam or tolfenamic acid administration on the pain and stress responses of Merino lambs to mulesing. Australian Veterinary Journal 86, 303311.
Paull, D, Lee, C, Colditz, I, Atkinson, S and Fisher, A 2007. The effect of a topical anaesthetic formulation, systemic flunixin and carprofen, singly or in combination, on cortisol and behavioural responses of Merino lambs to mulesing. Australian Veterinary Journal 85, 98106.
Phillips, CJ 2009. A review of mulesing and other methods to control flystrike (cutaneous myiasis) in sheep. Animal Welfare 18, 113121.
Ricciotti, E and FitzGerald, GA 2011. Prostaglandins and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology 31, 9861000.
Sackett, D, Holmes, P, Abbott, K, Jephcott, S and Barber, M 2006. Assessing the economic cost of endemic disease on the profitability of Australian beef cattle and sheep producers. Meat and Livestock Australia, Sydney, NSW, Australia.
Schweitzer, A, Hasler-Nguyen, N and Zijlstra, J 2009. Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats. BMC Pharmacology 9, 5.
Sheil, ML 2015. Analgesia for surgical husbandry procedures in sheep and other livestock. Animal Ethics Pty Ltd, Associate Sydney University Faculty of Veterinary Science, Sydney, NSW, Australia.
Shukla, M, Singh, G, Sindhura, B, Telang, A, Rao, G and Malik, J 2007. Comparative plasma pharmacokinetics of meloxicam in sheep and goats following intravenous administration. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 145, 528532.
Shutt, D, Fell, L, Connell, R, Bell, A, Wallace, C and Smith, A 1987. Stress-induced changes in plasma concentrations of immunoreactive ß-endorphin and cortisol in response to routine surgical procedures in lambs. Australian Journal of Biological Sciences 40, 97104.
Small, A, Belson, S, Holm, M and Colditz, I 2014. Efficacy of a buccal meloxicam formulation for pain relief in Merino lambs undergoing knife castration and tail docking in a randomised field trial. Australian Veterinary Journal 92, 381388.
Stock, ML, Coetzee, JF, KuKanich, B and Smith, BI 2013. Pharmacokinetics of intravenously and orally administered meloxicam in sheep. American Journal of Veterinary Research 74, 779783.
Thornton, P and Waterman-Pearson, A 1999. Quantification of the pain and distress responses to castration in young lambs. Research of Veterinary Science 66, 107118.
VSN International 2017. Genstat Reference Manual. VSN International, Hemel Hempstead, UK.
Welsh, E, McKellar, Q and Nolan, A 1993. The pharmacokinetics of flunixin meglumine in the sheep. Journal of Veterinary Pharmacology and Therapeutics 16, 181188.
Zöls, S, Ritzmann, M and Heinritzi, K 2005. Effect of analgesics on the castration of male piglets. Berliner Und Munchener Tierarztliche Wochenschrift 119, 193196.

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