Skip to main content Accessibility help
×
Home

Power of different F2 schemes for QTL detection in livestock

  • L. Alfonso (a1) and C. S. Haley (a1)

Abstract

The power for detection of quantitative trait loci (QTL) using marker information was compared in several schemes differing in the mating type and the number of parents involved. An experiment based on an F2 population of fixed size obtained by crossing two lines differing phenotypically for a single trait was simulated, assuming that QTLs could be fixed or segregating in the lines crossed. Different additive and dominant QTL effect values and allele frequencies were considered covering a range of different favourable situations for the detection of the QTL. Comparison was done by regression using flanking marker information. Mating animals at the F1 generation level minimizing relationships was not worse than mating at random or maximizing relationships. The number of parents used affected the power of the experiment when the QTL was segregating in the original crossed lines. Differences in power were mainly related to the number of males from the original line. When the power of the experiment was high as a result of genetic hypothesis assumed, considering several males increased the power. However, when the genetic hypothesis assumed led there to be less power to detect a QTL, the power was higher when fewer males were used.

Copyright

References

Hide All
Andersson, L., Haley, C. S., Ellegren, H., Knott, S. A., Johansson, M., Andersson, K., Andersson-Eklund, L., Edfors-Lilja, I., Fredholm, M., Hansson, I., Häkansson, J. and Lundstrom, K. 1994. Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science 263: 17711774.
Beckmann, J. S. and Soller, M. 1988. Detection of linkage between marker loci and loci affecting quantitative traits in crosses between segregating populations. Theoretical and Applied Genetics 76: 228236.
Bidanel, J. P., Milan, D., Chevalet, C., Woloszyn, N., Caritez, J. C., Cruand, J., Le Roy, P., Bonneau, M., Renard, C., Vaiman, M., Gellin, J. and Ollivier, L. 1996. Mapping quantitative trait loci in a Meishan × Large White F2 population. Forty-seventh annual meeting of the European Association for Animal Production, Lillehammer, Norway.
Blackman, R. G. and Tukey, J. W. 1958. The measurement of power spectra. Dover, New York.
Brenneman, R. A., Davis, S. K., Sanders, B. M., Burns, T. C., Wheeler, T. C., Turner, J. W. and Taylor, J. F. 1996. The polled locus maps to BTA1 in a Bos indicus × Bos taurus cross. Journal of Heredity 87: 156161.
Falconer, D. S. and Mackay, T. F. C. 1996. Introduction to Quantitative Genetics. Longman Group Ltd, Harlow, Essex.
Geldermann, H., Müller, E., Beeckmann, P., Knorr, C., Yue, G. and Moser, G. 1996. Mapping of quantitative-traitloci by means of marker genes in F2 generations of wild boar, Pietrain and Meishan pigs. Journal of Animal Breeding and Genetics 113: 381387.
Haley, C. S. and Knott, S. A. 1992. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69: 315324.
Haley, C. S., Knott, S. A. and Elsen, J. M. 1994. Mapping quantitative trait loci in crosses between outbred lines using least squares. Genetics 136: 11951207.
Morgan, B. J. T. 1984. Elements of simulation. Chapman and Hall, London.
Muranty, H. 1996. Power of test for quantitative trait loci detection using full-sib families in different schemes. Heredity 76: 156165.
Numerical Algorithms Group. 1992. The NAG Fortran Library manual. Numerical Algorithms Group Ltd, Oxford.
Rebai, A., Goffinet, B. and Mangin, B. 1995. Comparing power of different methods for QTL, detection. Biometrics 51: 8799.
Soller, M., Brody, T. and Genizi, A. 1976. On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines. Theoretical and Applied Genetics 47: 3539.
Visscher, P. M. and Haley, C. S. 1996. Detection of putative quantitative trait loci in line crosses under infinitesimal genetic models. Theoretical and Applied Genetics 93: 691702.
Xu, S. 1996. Mapping quantitative trait loci using four-way crosses. Genetical Research, Cambridge 68: 175181.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed