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Effects of the adrenal steroidogenesis inhibitor trilostane on serum cortisol concentrations and growth in pigs

Published online by Cambridge University Press:  02 September 2010

M. N. Sillence  and
T. D. Etherton
M. N. Sillence
Affiliation:
Department of Dairy and Animal Science, Pennsylvania State University, University Park, PA 16802, USA
T. D. Etherton
Affiliation:
Department of Dairy and Animal Science, Pennsylvania State University, University Park, PA 16802, USA
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Abstract

There is evidence that the growth of female rats and sheep may be constrained by physiological concentrations of glucocorticoid hormones. This study was designed to examine the effects of trilostane, an inhibitor of adrenal steroidogenesis, on serum cortisol concentrations and growth in pigs.

First, trilostane was tested at three doses (250 mg, 500 mg and 1000 mg per pig) to examine its effect on serum cortisol concentrations. A reduction in serum cortisol concentration was observed 2 to 4 h after oral administration of trilostane (P < 0·05) and the adrenal response to a challenge dose of ACTH was reduced 4 to 6 h after administration (P < 0·05), at all doses tested. In a second experiment, trilostane (9·24 mg/kg body weight) was administered orally to 10 pigs twice daily for 35 days to examine its effects on growth rate. A further 10 pigs received a placebo. Trilostane did not affect weight gain or carcass composition, but caused a reduction in food intake (P < 0·05). Adrenal weight was increased by trilostane treatment and liver weight was reduced.

These results show that trilostane is effective at lowering serum cortisol concentrations acutely, but suggest that physiological concentrations of glucocorticoid hormones may not retard growth rate in barrows.

Type
Papers
Information
Animal Production , Volume 48 , Issue 3 , June 1989 , pp. 585 - 589
Copyright
Copyright © British Society of Animal Science 1989

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References

REFERENCES

Jones, S. J. 1987. The effects of trilostane, an antiglucocorticoid, on muscle growth in broiler chickens. Journal of Animal Science 65: Suppl. 1, p. 262 (Abstr.).Google Scholar
Komanicky, P., Spark, R. F. and Melby, J. C. 1978. Treatment of Cushing's Syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. Journal of Clinical Endocrinology and Metabolism 47: 1042–1051.CrossRefGoogle ScholarPubMed
McGrath, J. A., Kelly, F. J. and Goldspink, D. F. 1981. The influence of contractile activity and age on the responsiveness of rat skeletal muscle to catabolic steroids. Advances in Physiological Science 24: 179–184.Google Scholar
Millward, D. J., Brown, J. G. and Odedra, B. 1981. Protein turnover in individual tissues with special emphasis on muscle. In Nitrogen Metabolism in Man (ed. Waterlow, J. C. and Stephen, J. M. L.), pp. 475–494. Applied Science Publishers, London.Google Scholar
National Research Council. 1979. Nutritional Requirements of Swine. 8th ed. National Academy of Sciences, Washington, DCGoogle Scholar
Odedra, B., Bates, P. C. and Millward, D. J. 1983. Time course of the effect of catabolic doses of corticosterone on protein turnover in rat skeletal muscle and liver. Biochemical Journal 214: 617–627.CrossRefGoogle ScholarPubMed
Potts, G. O., Creange, J. E., Harding, H. R. and Schane, H. P. 1978. Trilostane, an orally active inhibitor of adrenal steroid biosynthesis. Steroids 32: 257–267.CrossRefGoogle Scholar
Sharpe, P. M., Buttery, P. J. and Haynes, N. B. 1984. Glucocorticoid status and growth manipulation in sheep. Canadian Journal of Animal Science 64: Suppl., pp. 310–311.CrossRefGoogle Scholar
Sillence, M. N. 1985. The role of the adrenal gland in the control of growth, pp. 161–174. Ph.D. Thesis, University of Leeds.Google Scholar
Sillence, M. N. and Etherton, T. D. 1987. Determination of the temporal relationship between porcine growth hormone, serum IGF-1 and cortisol concentrations in pigs. Journal of Animal Science 64: 1019–1023.CrossRefGoogle ScholarPubMed
Sillence, M. N. and Rodway, R. G. 1987. Age- and sex-dependent stimulation of growth rate in rats by the adrenal inhibitor trilostane. Journal of Endocrinology 113: 479–484.CrossRefGoogle ScholarPubMed
Sillence, M. N., Thomas, K. M., Anil, H., Redfern, E. J. and Rodway, R. G. 1987. Adrenal function in lambs treated with androgenic and oestrogenic growth stimulants. Animal Production 44: 241–249.Google Scholar
Thomas, K. M. and Rodway, R. G. 1983. Effects of trenbolone acetate on adrenal function and hepatic enzyme activities in female rats. Journal of Endocrinology 98: 121–127.CrossRefGoogle ScholarPubMed
Young, V. R. 1970. The role of skeletal and cardiac muscle in the regulation of protein metabolism. In Mammalian Protein Metabolism (ed. Munro, H. N.), Vol. 4, pp. 585–675. Academic Press, New York.CrossRefGoogle Scholar
Wangsness, P. J., Martin, R. J. and Gahagan, J. H. 1977. Insulin and growth hormone in lean and obese pigs. American Journal of Physiology 233: E104–E108.Google ScholarPubMed