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Effect of naturally occurring and synthetic androgens on growth, body composition and muscle glucocorticoid receptors in wether lambs

Published online by Cambridge University Press:  02 September 2010

H. Gallbraith  and
A. D. Berry
H. Gallbraith
Affiliation:
University of Aberdeen, School of Agriculture, 581 King Street, Aberdeen AB9 1UD
A. D. Berry
Affiliation:
University of Aberdeen, School of Agriculture, 581 King Street, Aberdeen AB9 1UD
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Abstract

Twenty-five Border Leicester ♂ × Blackface ♀ wether lambs aged about 4 months and weighing on average 28·5 kg were allocated to be treated with the naturally occurring steroid testosterone or trenbolone acetate or nandrolone phenylpropionate which are steroids synthetically produced. Treatment groups were as follows: untreated controls (C); 50 mg testosterone (T); 50 mg trenbolone acetate (TA); 50 mg testosterone + 50 mg trenbolone acetate (TTA) or 50 mg nandrolone phenylpropionate (N). Implants were given at 100 and again at 63 days before slaughter. The lambs were offered to appetite a good quality diet containing, per kg dry matter, an estimated 11·0 MJ metabolizable energy and 185 g crude protein. Comparisons were made for the main effects of T and TA and also interactions between T and TA. Effects due to N were assessed statistically against untreated controls. Treatment with T, on average, increased live-weight gain (LWG), empty body weight (EBW) and reduced backfat thickness and the weight (g/kg EBW) of perirenal and retroperitoneal fat. Main effects due to TA were increases in killing-out ratio and depth of the gigot joint and reductions in backfat thickness. Treatment with N increased the empty body weight and (g/kg) carcass ash. Non-significant (P > 0·05) trends were suggested for increases in carcass crude protein due to T and TA treatments. T and TA but not N treatments exhibited marked androgenic activity in increasing the weight (mg/kg EBW) of the accessary vesicular gland. TA and N, but not T, reduced the weight (g/kg EBW) of the thymus gland.

The maximum binding capacity of post-morte m skeletal muscle (m. gluteus) for (3H)-dexamethasone was reduced by TA but increased by T and N. These results suggest differences in the binding capacity of corticosteroid receptors which may be related to differences in the effects of T and TA on protein metabolism in skeletal muscle.

Keywords

androgensbody compositionglucocorticoidsgrowthsheep
Type
Research Article
Information
Animal Production , Volume 58 , Issue 3 , June 1994 , pp. 357 - 364
Copyright
Copyright © British Society of Animal Science 1994

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References

Bohorov, O., Buttery, P. J., Correia, J. H. R. D. and Soar, J. B. 1987. The effect of the β-2-adrenergic agonist clenbuterol or implantation with oestradiol plus trenbolone acetate on protein metabolism in wether lambs. British Journal of Nutrition 57:99–107.CrossRefGoogle ScholarPubMed
Coelho, J. F. S., Galbraith, H. and Topps, J. H. 1981. The effect of a combination of trenbolone acetate and oestradiol-17β on growth performance and blood, carcass and body characteristics of wether lambs. Animal Production 32:261–266.Google Scholar
Everitt, G. C. and Jury, K. E. 1966. Effect of sex and gonadectomy on the growth and development of Southdown × Romney Cross lambs. Part 1. Effects of live-weight growth and components of live weight. Journal of Agricultural Science, Cambridge 66:1–14.CrossRefGoogle Scholar
Galbraith, H. 1980. The effect of trenbolone acetate on growth, blood hormones and metabolites and nitrogen balance of beef heifers. Animal Production 30:389–394.Google Scholar
Galbraith, H., Hatendi, P. R., Alderson, E. M. and Scaife, J. R. 1990. The effect of cimaterol and oestradiol-17β alone or combined on growth and body composition of wether lambs. Animal Production 51:311–319.Google Scholar
Galbraith, H. and Topps, J. H. 1981. Effect of hormones on the growth and body composition of animals. Nutrition Abstracts and Reviews, series B 51:521–540.Google Scholar
Hancock, D. R., Wagner, J. F. and Anderson, D. B. 1991. Effects of estrogens and androgens on animal growth. In Growth regulation in farm animals. Advances in meat research volume 7 (ed. Pearson, A. M. and Dutson, T. R.), pp. 255–297. Elsevier Applied Science, London.Google Scholar
Heitzman, R. J. 1976. The effectiveness of anabolic agents in increasing growth rate in farm animals. In Anabolic agents in animal production (ed. Rendel, F. C. Lu and J.), pp. 89–98. Georg Thieme Publishers, Stuttgart.Google Scholar
Lawes Agricultural Trust. 1977. Genstat V, mark 4.01. Rothamsted Experimental Station, Harpenden, Hertfordshire.Google Scholar
MacVinish, L. J. and Galbraith, H. 1988. The effect of implantation of trenbolone acetate and oestradiol-17β in wether lambs at two initial live weights on concentrations of steroidal residues and blood glucose, urea and thyroid hormones. Animal Production 47:75–85.Google Scholar
MacVinish, L. J. and Galbraith, H. 1993. A note on the concentrations of steroidal residues in tissues of mature female sheep implanted with trenbolone acetate. Animal Production 56:277–280.Google Scholar
Neumann, F. 1976. Pharmacological and endocrinological studies on anabolic agents. In Anabolic agents in animal production (ed. Rendel, F. C. Lu and J.), pp. 253–264. Georg Thieme Publishers, Stuttgart.Google Scholar
Sharpe, P. M., Buttery, P. J. and Haynes, N. B. 1986. The effect of manipulating growth in sheep by diet or anabolic agents on plasma cortisol and muscle glucocorticoid receptors. British journal of Nutrition 56:289–304.CrossRefGoogle ScholarPubMed
Singh, S. B., Galbraith, H., Scaife, J. R. and Hunter, E. A. 1985. Effect of oestrogenic and androgenic compounds on growth and body composition of male castrate lambs. Proceedings of the Nutrition Society 44:93A (abstr.).Google Scholar
Skeggs, L. T. and Hochstrasser, H. 1964. Multiple automatic sequestrial analysis. Clinical Chemistry 10:918–926.CrossRefGoogle ScholarPubMed
Snowchowski, M., Dahlberg, E. and Gustafsson, J. A. 1980. Characterisation and quantification of the androgen and glucocorticoid receptors in cytosol from rat skeletal muscle. European Journal of Biochemistry III:603–616.CrossRefGoogle Scholar
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1986. Growth performance and body composition of early weaned wether lambs treated with trenbolone acetate combined with oestradiol-17β. Animal Production 43:109–114.Google Scholar
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1988. Growth performance and body composition of wether lambs implanted at two different initial live weights with trenbolone acetate combined with oestradiol-17β. Animal Production 47:65–74.Google Scholar
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1992. Growth performance and body composition of mature female sheep implanted with trenbolone acetate. Animal Production 54:53–58.Google Scholar