Skip to main content Accessibility help
×
Home

Effect of naturally occurring and synthetic androgens on growth, body composition and muscle glucocorticoid receptors in wether lambs

  • H. Gallbraith (a1) and A. D. Berry (a1)

Abstract

Twenty-five Border Leicester ♂ × Blackface ♀ wether lambs aged about 4 months and weighing on average 28·5 kg were allocated to be treated with the naturally occurring steroid testosterone or trenbolone acetate or nandrolone phenylpropionate which are steroids synthetically produced. Treatment groups were as follows: untreated controls (C); 50 mg testosterone (T); 50 mg trenbolone acetate (TA); 50 mg testosterone + 50 mg trenbolone acetate (TTA) or 50 mg nandrolone phenylpropionate (N). Implants were given at 100 and again at 63 days before slaughter. The lambs were offered to appetite a good quality diet containing, per kg dry matter, an estimated 11·0 MJ metabolizable energy and 185 g crude protein. Comparisons were made for the main effects of T and TA and also interactions between T and TA. Effects due to N were assessed statistically against untreated controls. Treatment with T, on average, increased live-weight gain (LWG), empty body weight (EBW) and reduced backfat thickness and the weight (g/kg EBW) of perirenal and retroperitoneal fat. Main effects due to TA were increases in killing-out ratio and depth of the gigot joint and reductions in backfat thickness. Treatment with N increased the empty body weight and (g/kg) carcass ash. Non-significant (P > 0·05) trends were suggested for increases in carcass crude protein due to T and TA treatments. T and TA but not N treatments exhibited marked androgenic activity in increasing the weight (mg/kg EBW) of the accessary vesicular gland. TA and N, but not T, reduced the weight (g/kg EBW) of the thymus gland.

The maximum binding capacity of post-morte m skeletal muscle (m. gluteus) for (3H)-dexamethasone was reduced by TA but increased by T and N. These results suggest differences in the binding capacity of corticosteroid receptors which may be related to differences in the effects of T and TA on protein metabolism in skeletal muscle.

Copyright

References

Hide All
Bohorov, O., Buttery, P. J., Correia, J. H. R. D. and Soar, J. B. 1987. The effect of the β-2-adrenergic agonist clenbuterol or implantation with oestradiol plus trenbolone acetate on protein metabolism in wether lambs. British Journal of Nutrition 57:99107.
Coelho, J. F. S., Galbraith, H. and Topps, J. H. 1981. The effect of a combination of trenbolone acetate and oestradiol-17β on growth performance and blood, carcass and body characteristics of wether lambs. Animal Production 32:261266.
Everitt, G. C. and Jury, K. E. 1966. Effect of sex and gonadectomy on the growth and development of Southdown × Romney Cross lambs. Part 1. Effects of live-weight growth and components of live weight. Journal of Agricultural Science, Cambridge 66:114.
Galbraith, H. 1980. The effect of trenbolone acetate on growth, blood hormones and metabolites and nitrogen balance of beef heifers. Animal Production 30:389394.
Galbraith, H., Hatendi, P. R., Alderson, E. M. and Scaife, J. R. 1990. The effect of cimaterol and oestradiol-17β alone or combined on growth and body composition of wether lambs. Animal Production 51:311319.
Galbraith, H. and Topps, J. H. 1981. Effect of hormones on the growth and body composition of animals. Nutrition Abstracts and Reviews, series B 51:521540.
Hancock, D. R., Wagner, J. F. and Anderson, D. B. 1991. Effects of estrogens and androgens on animal growth. In Growth regulation in farm animals. Advances in meat research volume 7 (ed. Pearson, A. M. and Dutson, T. R.), pp. 255297. Elsevier Applied Science, London.
Heitzman, R. J. 1976. The effectiveness of anabolic agents in increasing growth rate in farm animals. In Anabolic agents in animal production (ed. Rendel, F. C. Lu and J.), pp. 8998. Georg Thieme Publishers, Stuttgart.
Lawes Agricultural Trust. 1977. Genstat V, mark 4.01. Rothamsted Experimental Station, Harpenden, Hertfordshire.
MacVinish, L. J. and Galbraith, H. 1988. The effect of implantation of trenbolone acetate and oestradiol-17β in wether lambs at two initial live weights on concentrations of steroidal residues and blood glucose, urea and thyroid hormones. Animal Production 47:7585.
MacVinish, L. J. and Galbraith, H. 1993. A note on the concentrations of steroidal residues in tissues of mature female sheep implanted with trenbolone acetate. Animal Production 56:277280.
Neumann, F. 1976. Pharmacological and endocrinological studies on anabolic agents. In Anabolic agents in animal production (ed. Rendel, F. C. Lu and J.), pp. 253264. Georg Thieme Publishers, Stuttgart.
Sharpe, P. M., Buttery, P. J. and Haynes, N. B. 1986. The effect of manipulating growth in sheep by diet or anabolic agents on plasma cortisol and muscle glucocorticoid receptors. British journal of Nutrition 56:289304.
Singh, S. B., Galbraith, H., Scaife, J. R. and Hunter, E. A. 1985. Effect of oestrogenic and androgenic compounds on growth and body composition of male castrate lambs. Proceedings of the Nutrition Society 44:93A (abstr.).
Skeggs, L. T. and Hochstrasser, H. 1964. Multiple automatic sequestrial analysis. Clinical Chemistry 10:918926.
Snowchowski, M., Dahlberg, E. and Gustafsson, J. A. 1980. Characterisation and quantification of the androgen and glucocorticoid receptors in cytosol from rat skeletal muscle. European Journal of Biochemistry III:603616.
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1986. Growth performance and body composition of early weaned wether lambs treated with trenbolone acetate combined with oestradiol-17β. Animal Production 43:109114.
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1988. Growth performance and body composition of wether lambs implanted at two different initial live weights with trenbolone acetate combined with oestradiol-17β. Animal Production 47:6574.
Sulieman, A. H., Galbraith, H. and Topps, J. H. 1992. Growth performance and body composition of mature female sheep implanted with trenbolone acetate. Animal Production 54:5358.

Keywords

Related content

Powered by UNSILO

Effect of naturally occurring and synthetic androgens on growth, body composition and muscle glucocorticoid receptors in wether lambs

  • H. Gallbraith (a1) and A. D. Berry (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.