Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-19T02:14:08.619Z Has data issue: false hasContentIssue false
  • English
  • Français

Update on bacterial pathogenesis in BRD

Published online by Cambridge University Press:  15 December 2009

Anthony W. Confer
Anthony W. Confer*
Affiliation:
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078-2007, USA
*
E-mail: anthony.confer@okstate.edu
Get access Rights & Permissions [Opens in a new window]

Abstract

Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Mycoplasma bovis and Arcanobacterium pyogenes are all frequently implicated in bovine respiratory disease (BRD). M. haemolytica is considered the most important of the group. These bacteria are commensals in the nasopharynx and establish infection in the lungs of cattle that are subjected to a variety of stresses. Factors that permit adherence to and proliferation in the lungs and factors that cause tissue destruction and inflammation have been identified as having major roles in pathogenesis. These virulence factors include protein adhesins, capsular polysaccharide, outer membrane proteins, iron-binding proteins, lipopolysacharide or lipooligosaccharide, enzymes and toxins. These bacterial products function to evade the immune system, damage the immune system and induce a severe inflammatory response.

Keywords

Mannheimia haemolyticaPasteurella multocidaHistophilus somniArcanobacterium pyogenesBibersteinia trehalosiMycoplasma bovis
Type
Review Article
Information
Animal Health Research Reviews , Volume 10 , Issue 2 , December 2009 , pp. 145 - 148
Copyright
Copyright © Cambridge University Press 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allen, JW, Viel, L, Bateman, KG, Nagy, E, Røsendal, S and Shewen, PE (1992). Serological titers to bovine herpesvirus 1, bovine viral diarrhea virus, parainfluenza 3 virus, bovine respiratory syncytial virus and Pasteurella haemolytica in feedlot calves with respiratory disease: associations with bacteriological and pulmonary cytological variables. Canadian Journal of Veterinary Research 156: 281–288.Google Scholar
Blackall, PJ, Bojesen, AM, Christensen, H and Bisgaard, M (2007). Reclassification of [Pasteurella] trehalosi as Bibersteinia trehalosi gen. nov., comb. nov. International Journal of Systematic and Evolutionary Microbiology 57: 666–674.CrossRefGoogle ScholarPubMed
Booker, CW, Abutarbush, SM, Morley, PS, Jim, GK, Pittman, TJ, Schunicht, OC, Perrett, T, Wildman, BK, Fenton, RK, Guichon, PT and Janzen, ED (2008). Microbiological and histopathological findings in cases of fatal bovine respiratory disease of feedlot cattle in Western Canada. Canadian Veterinary Journal 49: 473–481.Google ScholarPubMed
Caswell, JL and Archambault, M (2007). Mycoplasma bovis pneumonia in cattle. Animal Health Research Reviews 8: 161–186.CrossRefGoogle ScholarPubMed
Caswell, JL and Williams, KJ (2007). Respiratory system. In: Maxie, MG (ed) Jubb, Kennedy and Palmer's Pathology of Domestic Animals, Vol. 2. Edinburgh, UK: Elsevier Ltd, pp. 601–615.Google Scholar
Catry, B, Croubels, S, Schwarz, S, Deprez, P, Cox, B, Kehrenberg, C, Opsomer, G, Decostere, A and Haesebrouck, F (2008). Influence of systemic fluoroquinolone administration on the presence of Pasteurella multocida in the upper respiratory tract of clinically healthy calves. Acta Veterinaria Scandinavica 50: 36–39.CrossRefGoogle ScholarPubMed
Confer, AW, Clinkenbeard, KD and Murphy, GL (1995). Pathogenesis and virulence of Pasteurella haemolytica in cattle: an analysis of current knowledge and future approaches. In: Donachie, W, Lainson, FA and Hodgson, JC (eds) Haemophilus, Actinobacillus and Pasteurella. London: Plenum, pp. 51–62.CrossRefGoogle Scholar
Corbeil, LB (2007). Histophilus somni host–parasite relationships. Animal Health Research Reviews 8: 151–160.CrossRefGoogle ScholarPubMed
Czuprynski, CJ and Welch, RA (1995). Biological effects of RTX toxins: the possible role of lipopolysaccharide. Trends in Microbiology 3: 480–483.CrossRefGoogle ScholarPubMed
Czuprynski, CJ, Leite, F, Sylte, M, Kuckleburg, C, Schultz, R, Inzana, T, Behling-Kelly, E and Corbeil, L (2004). Complexities of the pathogenesis of Mannheimia haemolytica and Haemophilus somnus infections: challenges and potential opportunities for prevention? Animal Health Research Reviews 5: 277–282.CrossRefGoogle ScholarPubMed
Dabo, SM, Taylor, JD and Confer, AW (2007). Pasteurella multocida and bovine respiratory disease. Animal Health Research Reviews 8: 129–150.CrossRefGoogle ScholarPubMed
Dungworth, DC (1985). The respiratory system. In: Jubb, KVF, Kennedy, PC and Palmer, N (eds) Pathology of Domestic Animals. Orlando, FL: Academic Press, pp. 448–489.Google Scholar
Gagea, MI, Bateman, KG, Shanahan, RA, van Dreumel, T, McEwen, BJ, Carman, S, Archambault, M and Caswell, JL (2006a). Naturally occurring Mycoplasma bovis-associated pneumonia and polyarthritis in feedlot beef calves. Journal of Veterinary Diagnostic Investigation 18: 29–40.CrossRefGoogle ScholarPubMed
Gagea, MI, Bateman, KG, van Dreumel, T, McEwen, BJ, Carman, S, Archambault, M, Shanahan, RA and Caswell, JL (2006b). Diseases and pathogens associated with mortality in Ontario beef feedlots. Journal of Veterinary Diagnostic Investigation 18: 18–28.CrossRefGoogle ScholarPubMed
Goodwin-Ray, KA, Stevenson, MA and Heuer, C (2008). Effect of vaccinating lambs against pneumonic pasteurellosis under New Zealand field conditions on their weight gain and pneumonic lung lesions at slaughter. Veterinary Record 162: 9–11.CrossRefGoogle ScholarPubMed
Harper, M, Boyce, JD and Adler, B (2006). Pasteurella multocida pathogenesis: 125 years after Pasteur. FEMS Microbiology Letters 265: 1–10.CrossRefGoogle ScholarPubMed
Hoshinoo, K, Sasaki, K, Tanaka, A, Corbeil, LB and Tagawa, Y (2009). Virulence attributes of Histophilus somni with a deletion mutation in the ibpA gene. Microbial Pathogenesis 46: 273–282.CrossRefGoogle ScholarPubMed
Jost, BH and Billington, SJ (2005). Arcanobacterium pyogenes: molecular pathogenesis of an animal opportunist. Antonie Van Leeuwenhoek 88: 87–102.CrossRefGoogle ScholarPubMed
Khodakaram-Tafti, A and López, A (2004). Immunohistopathological findings in the lungs of calves naturally infected with Mycoplasma bovis. Journal of Veterinary Medicine A: Physiology, Pathology, and Clinical Medicine 51: 10–14.CrossRefGoogle ScholarPubMed
Lopez, A (2007). Respiratory system. In: McGavin, MD and Zachary, JF (eds) Pathologic Basis of Veterinary Disease, 4th edn.St. Louis, MO: Mosby, pp. 463–558.Google Scholar
Pietrocola, G, Valtulina, V, Rindi, S, Jost, BH and Speziale, P (2007). Functional and structural properties of CbpA, a collagen-binding protein from Arcanobacterium pyogenes. Microbiology 153: 3380–3389.CrossRefGoogle ScholarPubMed
Rice, JA, Carrasco-Medina, L, Hodgins, DC and Shewen, PE (2007). Mannheimia haemolytica and bovine respiratory disease. Animal Health Research Reviews 8: 117–128.CrossRefGoogle ScholarPubMed
Rudnick, ST, Jost, BH and Billington, SJ (2008). Transcriptional regulation of pyolysin production in the animal pathogen, Arcanobacterium pyogenes. Veterinary Microbiology 132: 96–104.CrossRefGoogle ScholarPubMed
Sandal, I, Shao, JQ, Annadata, S, Apicella, MA, Boye, M, Jensen, TK, Saunders, GK and Inzana, TJ (2009). Histophilus somni biofilm formation in cardiopulmonary tissue of the bovine host following respiratory challenge. Microbes and Infection 11: 254–263.CrossRefGoogle ScholarPubMed
Thomson, RG (1984). Pathogenesis of pneumonia in feedlot cattle. In: Loan, RW (ed.) Bovine Respiratory Disease: A Symposium. College Station, TX: Texas A&M University Press, pp. 326–346.Google Scholar
Welsh, RD, Dye, LB, Payton, ME and Confer, AW (2004). Frequency of isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994–2002. Journal of Veterinary Diagnostic Investigation 16: 426–431.CrossRefGoogle Scholar