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Swine vesicular disease virus. Pathology of the disease and molecular characteristics of the virion

Published online by Cambridge University Press:  28 February 2007

Estela Escribano-Romero ,
Miguel Angel Jiménez-Clavero  and
Victoria Ley
Estela Escribano-Romero
Affiliation:
Instituto Nacional de Investigaciones Agrarias y Alimentarias, 28040, Madrid, Spain
Miguel Angel Jiménez-Clavero
Affiliation:
Instituto Nacional de Investigaciones Agrarias y Alimentarias, 28040, Madrid, Spain
Victoria Ley*
Affiliation:
Instituto Nacional de Investigaciones Agrarias y Alimentarias, 28040, Madrid, Spain
*
*INIA, Crta Coruña Km 7.5, 28040 Madrid, Spain e-mail: ley@inia.es
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Abstract

Swine vesicular disease is a highly contagious disease of pigs that is caused by an enterovirus of the family Picornaviridae. The virus is a relatively recent derivative of the human coxsackievirus B5, with which it has high molecular and antigenic homology. The disease is not severe, and affected animals usually show moderate general weakening and slight weight loss that is recovered in few days, as well as vesicular lesions in the mucosa of the mouth and nose and in the interdigital spaces of the feet. However, the similarity of these lesions to those caused by foot-and-mouth disease virus has led to the inclusion of this virus in list A of the Office International des Epizooties. The disease has been eradicated in the European Union except in Italy, where it is considered endemic in the south. Nevertheless, as occasional outbreaks still appear and must be eliminated rapidly, European countries are on the alert and farms are monitored routinely for the presence of the virus. This circumstance has led to a considerable effort to study the pathology of the disease and the molecular biology and antigenicity of the virus, and to the development of optimized methods for the diagnosis of the infection.

Type
Research Article
Information
Animal Health Research Reviews , Volume 1 , Issue 2 , December 2000 , pp. 119 - 126
Copyright
Copyright © CAB International 2000

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