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How stress alters immune responses during respiratory infection

  • Philip Griebel (a1), Kevin Hill (a2) and Joseph Stookey (a3)

Abstract

Fall-weaned calves entering the feedlot experience a variety of psychological and physical stressors, including maternal separation, transportation, social mixing, restraint, and dietary changes. Mixing calves from multiple sources also exposes them to respiratory pathogens at a time when maternal immunity has waned. Using an experimental bovine respiratory disease (BRD) challenge, we analyzed the effects of specific stressors on clinical disease and immune responses following bovine herpes virus (BHV-1/IBR) infection of naïve calves. Transportation stress was compared to either abrupt weaning plus transportation or transportation following a two-step weaning process. Transportation alone significantly (P < 0.05) increased BHV-1 shedding in nasal secretions despite elevated interferon-gamma production in the upper respiratory tract. In contrast, abrupt weaning and transportation, significantly (P < 0.05) increased serum haptoglobin on day 3 post-infection (PI) and blood leukocyte tumor necrosis factor α secretion on day 5 PI. These systemic responses were reduced by instituting a two-step weaning process 4 days prior to transportation and BHV-1 infection. In conclusion, these observations are consistent with earlier studies implicating weaning and transportation as stressors contributing to BRD severity and mortality. Current studies also revealed that different stressors or combination of stressors have distinct effects on host responses to viral infection in naïve calves.

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Corresponding author

*Corresponding author. E-mail: Philip.griebel@usask.ca

References

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Aich, P, Babiuk, LA, Potter, A and Griebel, PJ (2009). Biomarkers for prediction of bovine respiratory disease outcome. OMICS A Journal of Integrative Biology 13: 111.
Babiuk, LA, Lawman, MJ and Gifford, GA (1987). Use of recombinant bovine alpha 1 interferon in reducing respiratory disease induced by bovine herpesvirus type 1. Antimicrobial Agents and Chemotherapeutics 31: 752757.
Blecha, F and Minocha, HC (1983). Suppressed lymphocyte blastogenic responses and enhanced in vitro growth of infectious bovine rhinotracheitis virus in stressed feeder calves. American Journal of Veterinary Research 44: 21454218.
Cole, NA, Camp, TH, Rowe, LD Jr, Stevens, DG and Hutcheson, DP (1988). Effect of transport on feeder calves. American Journal of Veterinary Research 49: 178183.
Duff, GC, Galyean, ML (2007). Board-invited review: recent advances in management of highly stressed, newly received feedlot cattle. Journal of Animal Science 85: 823840.
Godson, DL, Baca-Estrada, ME, Van Kessel, AG, Hughes, HP, Morsy, MA, Van Donkersgoed, J, Harland, RJ, Shuster, DE, Daley, MJ and Babiuk, LA (1995). Regulation of bovine acute phase responses by recombinant interleukin-1 beta. Canadian Journal of Veterinary Research 59: 249255.
Graham, NM, Douglas, RM and Ryan, P (1986). Stress and acute respiratory infection. American Journal of Epidemiology 124: 389401.
Haley, DB, Bailey, DW and Stookey, JM (2005). The effects of weaning beef calves in two stages on their behavior and growth rate. Journal of Animal Science 83: 22052214.
Hodgson, P, Stookey, J, Popowych, Y, Potter, A, Babiuk, L and Griebel, PJ (2012). Stress significantly increases mortality following a secondary bacterial respiratory infection. Veterinary Research 43: 2129.
Hoerlein, AB and Marsh, CL (1957). Studies on the epizootiology of shipping fever in calves. Journal of the American Veterinary Medical Association 131: 123127.
Jensen, R, Pierson, RE, Braddy, PM, Saari, DA, Lauerman, LH, England, JJ, Keyvanfar, H, Collier, JR, Horton, DP, McChesney, AE, Benitez, A and Christie, RM (1976). Shipping fever pneumonia in yearling feedlot cattle. Journal of the American Veterinary Medical Association 169: 500506.
Miles, DG (2009). Overview of the North American beef cattle industry and the incidence of bovine respiratory disease (BRD). Animal Health Research Reviews 10: 101103.
Mookherjee, N, Wilson, HL, Doria, S, Popowych, Y, Falsafi, R, Yu, J, Li, Y, Veatch, S, Roche, FM, Brown, KL, Brinkman, FSL, Hokamp, K, Potter, A, Babiuk, LA, Griebel, PJ and Hancock, REW (2006). Bovine and human cathelicidin cationic host defence peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide. Journal of Leukocyte Biology 80: 15681574.
Pastoret, P-P, Babiuk, LA, Misra, V and Griebel, P (1980). Reactivation of temperature-sensitive and non-temperature-sensitive infections of bovine rhinotracheitis vaccine virus. Infection and Immunity 29: 483488.
Raggo, C, Habermehl, M, Babiuk, LA and Griebel, PJ (2000). In vivo effects of a recombinant bovine herpesvirus-1 vector expressing bovine interferon-gamma. Journal of General Virology 81: 26652673.
Ribble, CS, Meek, AH, Shewen, PE, Jim, GK and Guichon, PT (1995). Effect of transportation on fatal fibrinous pneumonia and shrinkage in calves arriving at a large feedlot. Journal of the American Veterinary Medical Association 207: 612615.
Smith, RA (2009). North American cattle marketing and bovine respiratory disease (BRD). Animal Health Research Reviews 10: 105108.
Snowder, GD, Van Vleck, LD, Cundiff, LV and Bennett, GL (2006). Bovine respiratory disease in feedlot cattle: environmental, genetic, and economic factors. Journal of Animal Science 84: 19992008.
Stanton, A (2009). Challenges and opportunities for managing respiratory disease in dairy calves. Animal Health Research Reviews 10: 113115.
Step, DL, Krehbiel, CR, DePra, HA, Cranston, JJ, Fulton, RW, Kirkpatrick, JG, Gill, DR, Payton, ME, Montelongo, MA and Confer, AW (2008). Effects of commingling beef calves from different sources and weaning protocols during a forty-two-day receiving period on performance and bovine respiratory disease. Journal of Animal Science 86: 31463158.

Keywords

How stress alters immune responses during respiratory infection

  • Philip Griebel (a1), Kevin Hill (a2) and Joseph Stookey (a3)

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