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Alphavirus replicon vaccines

Published online by Cambridge University Press:  21 March 2012

Ryan L. Vander Veen*
Harrisvaccines Inc., Ames, IA 50010, USA Immunobiology Program, Iowa State University, Ames, IA 50011, USA Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
D. L. Hank Harris
Harrisvaccines Inc., Ames, IA 50010, USA Department of Animal Science, College of Agriculture, Iowa State University, Ames, IA 50011, USA Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Ames, IA, 50011, USA
Kurt I. Kamrud
Harrisvaccines Inc., Ames, IA 50010, USA Department of Animal Science, College of Agriculture, Iowa State University, Ames, IA 50011, USA
*Corresponding author: E-mail:


The alphavirus replicon technology has been utilized for many years to develop vaccines for both veterinary and human applications. Many developments have been made to the replicon platform recently, resulting in improved safety and efficacy of replicon particle (RP) vaccines. This review provides a broad overview of the replicon technology and safety features of the system and discusses the current literature on RP and replicon-based vaccines.

Review Article
Copyright © Cambridge University Press 2012

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