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The Value of Measurement of Pregnancy-Specific Proteins in Twin Pregnancies

Published online by Cambridge University Press:  01 August 2014

V. Jandial
Affiliation:
Department of Obstetrics and Gynaecology and Department of Pathology, University of Aberdeen, UK
C. H. W. Horne
Affiliation:
Department of Obstetrics and Gynaecology and Department of Pathology, University of Aberdeen, UK
R. G. Glover
Affiliation:
Department of Obstetrics and Gynaecology and Department of Pathology, University of Aberdeen, UK
A. D. Nisbet
Affiliation:
Department of Obstetrics and Gynaecology and Department of Pathology, University of Aberdeen, UK
D. M. Campbell
Affiliation:
Department of Obstetrics and Gynaecology and Department of Pathology, University of Aberdeen, UK
I. MacGillivray
Affiliation:
Department of Obstetrics and Gynaecology and Department of Pathology, University of Aberdeen, UK

Abstract

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In this study of 53 twin pregnancies, the plasma concentrations of the placental proteins, placental lactogen (hPL), and pregnancy-specific glycoprotein (SP1) were measured. Placental lactogen was found to be of more value than SP1 both in the detection of twins and in assessment of fetal growth. Serial measurement of either protein would seem to be more useful in assessment of fetal growth than single measurements. Preliminary studies of the less well known placental protein, PP5, in a small series of twin pregnancies indicate that it may also prove to be of clinical value in the detection and monitoring of twin pregnancies.

Type
Session III: Management of Twin Pregnancy
Copyright
Copyright © The International Society for Twin Studies 1979

References

REFERENCES

1. Bonn, H (1972): Detection and characterization of soluble antigens in the human placenta. Arch Gynäkol 212:165175.Google Scholar
2. Bohn, H, Winckler, W (1977): Isolation and characterization of the placental protein PP5. Arch Gynäkol 223:179186.CrossRefGoogle ScholarPubMed
3. Chesworth, JM (1977): Radioimmunoassays of ovine LH and ovine prolactin using polymerized second antisera. Anal Biochem 80:3140.Google Scholar
4. Gordon, YB, Grudzinskas, JG, Jeffrey, D, Chard, T, Letchworth, AT (1977): Concentrations of pregnancy-specific β 1-glycoprotein in maternal blood in normal pregnancy and in intrauterine growth retardation. Lancet 1:331333.Google Scholar
5. Grennert, L, Persson, P-H, Grennser, G, Kullander, S, Thorell, J (1977): Ultrasound and human-placental-lactogen screening for early detection of twin pregnancies. Lancet 1:46.Google Scholar
6. Grudzinskas, JG, Gordon, YB, Jeffrey, D, Chard, T (1977): Specific and sensitive determination of pregnancy-specific β 1-glycoprotein by radioimmunoassay. A new pregnancy test. Lancet 1:333335.Google Scholar
7. Horne, CHW (1978): Unpublished data.Google Scholar
8. Horne, CHW, Towler, CM, Pugh-Humphreys, RGP, Thomson, AW, Bohn, H (1976): Pregnancy-specific β 1-glycoprotein – A product of the syncitiotrophoblast. Experientia 32:11971199.Google Scholar
9. Jandial, V, Towler, CM, Horne, CHW, Abramovich, DR (1978): Plasma pregnancy-specific β 1-glycoprotein in complications of early pregnancy. Br J Obstet Gynaecol 85:832836.CrossRefGoogle Scholar
10. Jovanovic, L, Landesman, R, Saxenna, BB (1977): Screening for twin pregnancy. Science 198:738.Google Scholar
11. Laurell, CB (1966): Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem 15:4552.CrossRefGoogle ScholarPubMed
12. Lin, T-M, Halbert, SP (1976): Placental localisation of human pregnancy-associated plasma proteins. Science 193:12491252.Google Scholar
13. Mancini, G, Carbonara, AO, Heremans, JF (1965): Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2:235254.Google Scholar
14. Obiekwe, BC, Grudzinskas, JG, Gordon, YB, Bohn, H, Chard, T (1979): Circulating levels of placental protein 5 (PP5) in the third trimester of pregnancy. In Lehmann, F-G (ed): “Carcino-Embryonic Proteins,” Vol II. Amsterdam: Elsevier, pp 629632.Google Scholar
15. Sedlacek, HH, Rehkopf, R, Bohn, H (1976): Immunofluorescence histological localisation of human pregnancy and placenta proteins in the placenta of man and monkeys. Behring Inst Mitt 59:8191.Google Scholar
16. Tatarinov, YS, Falaleeva, DM, Kalashnikov, VV, Toloknov, BO (1976): Immunofluorescent localisation of human pregnancy-specific β 1-globulin in placenta and chorioepithelioma. Nature 260:263.CrossRefGoogle Scholar
17. Tatra, G, Placheta, P, Breitenecker, G (1975): Pregnancy-specific β 1-glycoprotein (SP1). Clinical aspects. Wiener Klin Wochenschr 87:279281.Google Scholar
18. Teisner, B, Westergaard, JG, Folkersen, J, Husby, S, Svehag, SE (1978): Two pregnancy-associated serum proteins with pregnancy-specific-glycoprotein determinants. Am J Obstet Gynecol 131: 262266.Google Scholar
19. Thomson, AM, Billewicz, WZ, Hytten, FE (1968): The assessment of fetal growth. J Obstet Gynaecol Br Commonw 75:903916.CrossRefGoogle ScholarPubMed
20. Towler, CM, Horne, CHW, Jandial, V, Campbell, DM, Macgillivray, I (1976): Plasma levels of pregnancy-specific β 1-glycoprotein in normal pregnancy. Br J Obstet Gynaecol 83:775779.Google Scholar
21. Towler, CM, Horne, CHW, Jandial, V, Campbell, DM, Macgillivray, I (1977): Plasma levels of pregnancy-specific β 1-glycoprotein in complicated pregnancies. Br J Obstet Gynaecol 84:258263.Google Scholar
22. Towler, CM, Glover, RG, Horne, CHW (1978): Problems encountered in the measurement of pregnancy-specific β 1-glycoprotein. Clin Chim Acta 87:289296.CrossRefGoogle Scholar