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Plasma Protein Variability in Monozygotic Twins: Further Studies and Applications

  • M. Milani-Comparetti (a1), F. Britti (a2), D. Casini (a2), F. Saccucci (a1) and L. Gedda (a2)...

Abstract

Previous collaborative studies have shown the substantial superimposability of electrophoretic patterns of non-Ig plasma proteins in twin pairs only if MZ. The above findings provide the basis for (a) twin pair zygosity determinations and (b) studies aimed at discriminating genetic and environmental factors in the alteration of protein patterns in various diseases (especially neoplastic). Such studies require adequate standardization of methods, and the present paper offers a substantial contribution to the standardization of pattern comparisons.

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Copyright

Corresponding author

Istituto di Biologia e Genetica, Via Grotte di Posatora, 60100 Ancona, Italy

References

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Gedda, L., Milani-Comparetti, M., D'Alessandro, E. 1974. Equivocalness and other empirical methods in zigosity assessment. 1st Int. Congr. Twin Studies, Rome. Acta Genet. Med. Gemellol., (1976) 25: 117120.
Milani-Comparetti, M., Saccucci, F. 1974. Plasma protein variability in MZ twins. 1st. Int. Congr. Twin Studies, Rome. Acta Genet. Med. Gemellol., (1976) 25: 154156.
Sega, E., Isabella, F., Citro, G. 1971. Elettroforesi a disco su gel di acrilammide. Nota 1: Considerazioni preliminari su alcuni patterns normali e patologici. Boll. 1st. Sieroter. Milanese, 50: 422.

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