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Genetic Variance and Heritability of Serum Cholesterol and Triglycerides Among Chinese Twin Neonates

  • C.-J. Chen (a1), M.-W. Yu (a1), C.-J. Wang (a1), S.-L. Tong (a1), M. Tien (a1), T.-Y. Lee (a2), H.-C. Lue (a2), F.-Y. Huang (a3), C.-C. Lan (a3), K.-H. Yang (a4), H.-C. Wang (a4), H.-Y. Shin (a5), C.-Y. Liu (a5) and J.-S. Chen (a2)...

Abstract

In order to examine the genetic variance and heritability of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides, a total of 349 pairs of same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on the placental pattern and 12 red blood cell antigens, 271 monozygotic (MZ) and 78 dizygotic (DZ) twin pairs were identified. There was a significant genetic variance for total cholesterol, HDL-C, LDL-C, and triglycerides both unadjusted and adjusted for sex, gestational age and placentation. The unadjusted heritability of total cholesterol, HDL-C, LDL-C, and triglycerides was 0.59, 0.30, 0.25 and 0.75, respectively; while the corresponding adjusted heritability was 0.74, 0.38, 0.31, and 0.49, respectively. Intrapair variance of serum lipids was not significantly different between monochorionic and dichorionic MZ twins.

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Corresponding author

Institute of Public Health, National Taiwan University College of Medicine, 1, Jen-Ai Road Section 1, Taipei 10018, Taiwan, Republic of China

References

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1.Berg, K (1981): Twin research in coronary heart disease. In Gedda, L, Parisi, P, Nance, WE (eds): Twin Research 3: Part C, Epidemiology and Clinical Studies. New York: Alan R Liss, pp 117.
2.Chen, CJ, Cohen, BH, Diamond, EL, et al (1984): Genetic variance and heritability of cardiovascular risk factors in Chinese adolescent twins. Acta Genet Med Gemellol 33:363.
3.Chen, CJ, Lin, TM, Chang, C, et al (1987): Epidemiological characteristics of twinning rates in Taiwan. Acta Genet Med Gemellol 36:335.
4.Christian, JC (1979): Testing twin means and estimating genetic variance: basic methodology for the analysis of quantitative twin data. Acta Genet Med Gemellol 28:35.
5.Corey, LA, Kang, KW, Christian, JC, et al (1976): Effects of chorion type on variation in cord blood cholesterol of monozygotic twins. Am J Hum Genet 28:433.
6.Daccini Dal Colleto, GM, Krieger, H, Magalhaes, JR (1981): Estimates of genetic and environmental determinants of serum lipid and lipoprotein concentrations in Brazilian twins. Hum Hered 31:132.
7.Department of Health, Executive Yuan, Republic of China (1987): Health statistics. II. Vital statistics. Taipei: Department of Health.
8.Falconer, DS (1960): Quantitative genetics. New York: Ronald.
9.Garrison, RJ, Castelli, WP, Feinleib, M, et al (1979): The association of total cholesterol, triglycerides and plasma lipoprotein cholesterol levels in first degree relatives and spouse pairs. Am J Epidemiol 110:313.
10.Haseman, JK, Elston, RC (1970): The estimation of genetic variance from twin data. Behav Genet 1:11.
11.Hewitt, D, Milner, J, Breckenridge, C, et al (1976): A twin study on the heritability of lipoprotein fractions. Acta Genet Med Gemellol 25:150.
12.Kempthorne, O, Osborne, RH (1961): The interpretation of twin data. Am J Hum Genet 13:320.
13.Martin, AO, Kurczynski, TW, Steinberg, AG (1973): Familial studies of medical and anthropometric variables in a human isolate. Am J Hum Genet 25:584.
14.McMillan, GC (1973): Development of arteriosclerosis. Am J Cardiol 32:542.
15.Orchard, TJ, Rodgers, M, Hedley, AJ, et al (1981): Serum lipids in a teenage population. Geographic, seasonal and familial factors. Int J Epidemiol 10:161.
16.Shear, CL, Frerichs, RR, Weinberg, R, et al (1978): Childhood sibling aggregation of coronary artery disease risk factor variables in a biracial community. Am J Epidemiol 107:522.
17.Sing, CF, Orr, JD (1978): Analysis of genetic and environemtnal sources of variation in serum cholesterol in Tecumseh, Michigan. IV. Separation of polygene from common environment effects. Am J Hum Genet 30:491.
18.US National Institute of Health (1974): Manual of laboratory operations of the Lipid Research Clinics Programs. Lipids and lipoprotein analysis. Washington, DC: Govemment Printing Office (DHEW Publication No. (NIH) 75-628).
19.Weinberg, R, Avet, LM, Gardner, MJ (1976): Estimates of the heritability of serum lipoprotein and lipid concentrations. Clin Genet 9:588.

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Genetic Variance and Heritability of Serum Cholesterol and Triglycerides Among Chinese Twin Neonates

  • C.-J. Chen (a1), M.-W. Yu (a1), C.-J. Wang (a1), S.-L. Tong (a1), M. Tien (a1), T.-Y. Lee (a2), H.-C. Lue (a2), F.-Y. Huang (a3), C.-C. Lan (a3), K.-H. Yang (a4), H.-C. Wang (a4), H.-Y. Shin (a5), C.-Y. Liu (a5) and J.-S. Chen (a2)...

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