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Emoglobine fetali abnormi nella popolazione italiana1

Published online by Cambridge University Press:  01 August 2014

E. Silvestroni  and
I. Bianco
E. Silvestroni
Affiliation:
Istituto d'Igiene dell'Università di Roma
I. Bianco
Affiliation:
Centro di Studi della Microcitemia e delle Anemie Microcitemiche di Roma

Summary

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The authors explain 9 cases of Bart's Hb. and one case of Hb. Alexandra, identified on 3.556 blood samples from the umbilical-cord in human newborn in time. Electrophorectical and spectrophotometrical examinations showed that Bart's Hb. is identical to Hb. H2 (the least fast of the two Hb. fractions present into the bearers of Hb. H).

In 7 newborn infants, it has been possible with Bart's Hb. to reexamine them, some months after they were born; it was observed that the said haemoglobins had disappeared; at the same time, in 4 of those subjects, a clear microcytemic picture was noted while in 3 others, still very small, the microcytemic picture appeared still uncertain. In 8 families with newborn babies with Bart's Hb., the two parents were also examined, and in 7 of these families one of the two parents presented a microcytemic picture; in one of them the hematologic traits were normal in both parents, except a very hight alteration of the eritrocyte morphology in the mother.

None of the examined parents presented any abnormal haemoglobin; furthermore, all microcytemic parents (except one) and all children with Bart's Hb. presented a normal rate of Hb. A2. This fact, absolutely similar to that observed in the bearers of Hb. H and in their microcytemic relatives, allow to put forward the hypothesis that Bart's Hb. and Hb. H appear in the same families in which we find that special type of microcytemia without any increase of Hb. A2, which would correspond to the microcytemia of the α chain.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 10 , Issue 4 , October 1961 , pp. 470 - 484
Copyright
Copyright © The International Society for Twin Studies 1961

Footnotes

1

Le presenti ricerche sono state eseguite con un contributo del Consiglio Nazionale delle Ricerche.

References

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