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Down's Syndrome and Maternal Inbreeding*

  • Ei Matsunaga (a1)

Summary

In order to test the possible effect of maternal inbreeding upon non-disjunction, ancestors of 104 children with Down's syndrome born to younger mothers were identified on the basis of official records. Among them, 6 had related parents, while 10 of the fathers and 12 of the mothers had also such parents. The relationship comprises first-cousins, first-cousins once removed, and second cousins. It was concluded that recessive genes are unlikely to be involved in the aetiology of non-disjunction of the 21st autosome, at least in younger mothers.

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Copyright

Footnotes

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*

This paper is dedicated to Professor Dr. O. Frhr. von Verschuer in honour of his seventieth birthday. Contribution no. 618 from the National Institute of Genetics, Japan.

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References

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Forssman, H., Åkesson, H. O. (1966). Consanguineous Marriages and Mongolism. The Study Group on Mongolism. The Ciba Foundation, London.
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Hamerton, J. L. et al. (1965). Cytogenetics of Down's syndrome (Mongolism). I. Data on a consecutive series of patients referred for genetic counselling and diagnosis. Cytogenetics, 4: 171185.
Kamada, N. et al. (1965). Cytogenetic studies on Down's syndrome in Hiroshima and Nagasaki. Proc. Tenth Ann. Meet. Jap. Soc. Hum. Genet., Kumamoto, 10 9-10, (in Japanese).
Matsunaga, E. (1966). Parental age, live-birth order and pregnancy free interval in Down's syndrome in Japan. The Study Group on Mongolism. The Ciba Foundation, London.
Penrose, L. S. (1933). The relative effects of paternal and maternal age in mongolism. J. Genet., 27: 219224.
Penrose, L. S. (1961). Mongolism. Brit. Med. Bull., 17: 184189.
Sigler, A. T. et al. (1965). Parental age in Down's syndrome (mongolism). J. Pediat., 631642.
Tonomura, A. et al. (1965). Cytogenetic studies of 100 cases of Down's syndrome. Proc. Tenth Ann. Meet. Jap. Soc. Hum. Genet., Kumamoto, 10 9-10, (in Japanese).

Down's Syndrome and Maternal Inbreeding*

  • Ei Matsunaga (a1)

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