Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-19T21:20:16.312Z Has data issue: false hasContentIssue false
  • English
  • Français

Chronological Changes in Genetic Variance and Heritability of Systolic and Diastolic Blood Pressure Among Chinese Twin Neonates

Published online by Cambridge University Press:  01 August 2014

M.-W. Yu ,
C.-J. Chen ,
C.-J. Wang ,
S.-L. Tong ,
M. Tien ,
T.-Y. Lee ,
H.-C. Lue ,
F.-Y. Huang ,
C.-C. Lan  and
K.-H. Yang
...Show all authors
M.-W. Yu
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
C.-J. Chen*
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
C.-J. Wang
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
S.-L. Tong
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
M. Tien
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
T.-Y. Lee
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
H.-C. Lue
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
F.-Y. Huang
Affiliation:
Mckay Memorial Hospital, Taiwan, Republic of China
C.-C. Lan
Affiliation:
Mckay Memorial Hospital, Taiwan, Republic of China
K.-H. Yang
Affiliation:
Taipei Municipal Maternal and Child Hospital, Taiwan, Republic of China
H.-C. Wang
Affiliation:
Taipei Municipal Maternal and Child Hospital, Taiwan, Republic of China
H.-Y. Shih
Affiliation:
National Nursing School Hospital, Taipei, Taiwan, Republic of China
C.-Y. Liu
Affiliation:
National Nursing School Hospital, Taipei, Taiwan, Republic of China
J.-S. Chen
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
*
Institute of Public Health, National Taiwan University College of Medicine, 1, Jen-Ai Road Section 1, Taipei 10018, Taiwan, Republic of China

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In order to examine the chronological changes in genetic variance and heritability of arterial systolic and diastolic blood pressure (SBP and DBP) of Chinese infants in Taiwan, a total of 339 same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on placentation and 12 red blood cell antigens, 274 monozygotic (MZ) and 65 dizygotic (DZ) twin pairs were identified and followed up to the age of one year. Both SBP and DBP were measured by Doppler blood pressure monitor. Within-pair mean squares of SBP and DBP were consistently smaller in MZ than DZ twins at ages one month and over. The findings remained unchanged after the adjustment for the effects of age, sex, gestational age, placentation and physical state during blood pressure measurement. Falconer's heritability indices for adjusted SBP and DBP at ages two months and over ranged from 0.29 to 0.55 and from 0.27 to 0.45, respectively. The study indicates an important genetic influence on blood pressure during infancy.

Keywords

HeritabilityBlood pressureInfantsTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 1 , January 1990 , pp. 99 - 108
Copyright
Copyright © The International Society for Twin Studies 1990

References

REFERENCES

1.Annest, JL, Sing, CF, Biron, P, et al (1979): Familial aggregation of blood pressure and weight in adopted families. II. Estimation of the relative contributions of genetic and common environmental factors to blood pressure correlations between family members. Am J Epidemiol 110:492.Google Scholar
2.Austin, MA, King, M, Bawol, RD, et al (1987): Risk factors for coronary heart disease in adult female twins: Genetic heritability and shared environmental influences. Am J Epidemiol 125:308.CrossRefGoogle ScholarPubMed
3.Borhani, NO, Feinleib, M, Garrison, RJ, et al (1976): Genetic variance in blood pressure. Acta Genet Med Gemellol 25:137.Google Scholar
4.Buzzard, IM, Uchida, IA, Norton, JA Jr, et al (1983): Birth weight and placental proximity in like-sexed twins. Am J Hum Genet 35:318.Google ScholarPubMed
5.Chazan, JA, Winkelstein, W Jr (1964): Household aggregation of hypertension: Report of a preliminary study. J Chronic Dis 17:9.Google Scholar
6.Chen, CJ, Cohen, BH, Diamon, EL, et al (1984): Genetic variance and heritability of cardiovascular risk factors in Chinese adolescent twins. Acta Genet Med Gemellol 33:363.Google ScholarPubMed
7.Christian, JC, Norton, JA Jr (1977): A proposed test of the difference between the means of monozygotic twins. Acta Genet Med Gemellol 26:49.CrossRefGoogle Scholar
8.Christian, JC (1979): Testing twin means and estimating genetic variance: Basic methodology for the analysis of quantitative twin data. Acta Genet Med Gemellol 28:35.Google ScholarPubMed
9.Christian, JC, Kang, KW, Norton, JA Jr (1976): Choice of an estimate of genetic variance from twin data. Am J Hum Genet 26:154.Google Scholar
10.Corey, LA, Kang, KW, Christian, JC, et al (1976): Effects of chorion type on variation in cord blood cholesterol of monozygotic twins. Am J Hum Genet 28:433.Google Scholar
11.Falconer, DS (1960): Quantitative Genetics. New York: Ronald.Google Scholar
12.Feinleib, M, Garrison, RJ, Fabsitz, R, et al (1977): The NHLBI twin study of cardiovascular disease risk factors: Methodology and summary of results. Am J Epidemiol 106:284.CrossRefGoogle ScholarPubMed
13.Feinleib, M, Garrison, RJ, Havlik, RJ (1980): Environmental and genetic determinants of blood pressure in children. In: Lauer, RM, Shekelle, RB (eds): Childhood Prevention of Atherosclerosis and Hypertension. New York: Raven Press, p 271.Google Scholar
14.Haseman, JK, Elston, RC (1970): The estimation of genetic variance from twin data. Behav Genet 1:11.Google Scholar
15.Havlik, RJ, Garrison, RJ, Katz, SH, et al (1979): Detection of genetic variance in blood pressure of seven-year-old twins. Am J Epidemiol 109:512.CrossRefGoogle ScholarPubMed
16.Hennekens, CH, Jesse, MJ, Klein, BE, et al (1976): Aggregation of blood pressure in infants and their siblings. Am J Epidemiol 103:457.CrossRefGoogle ScholarPubMed
17.Kannel, WB, Dawber, TR, McGee, DL (1980): Perspectives on systolic hypertension: The Framingham study. Circulation 61:1179.Google Scholar
18.Katz, SH, Hediger, ML, Schall, JI, et al (1980): Blood pressure, growth and maturation from childhood through adolescence: Mixed longitudinal analyses of the Philadephia Blood Pressure Project. Hypertension 2 (Suppl I):55.Google Scholar
19.Kempthorne, O, Osborne, RH (1961): The interpretation of twin data. Am J Hum Genet 13:320.Google ScholarPubMed
20.Levine, RS, Hennekens, CH, Perry, A, et al (1982): Genetic variance of blood pressure levels in infant twins. Am J Epidemiol 116:759.Google Scholar
21.Levin, SE, Herman, AAB, Irwig, LM (1987): Systolic blood pressure differences in black, colored, and white infants. Am J Epidemiol 125:221.Google Scholar
22.Ljung, B, Stage, D, Carlsson, C (1975): Postnatal ontogenetic development of neurogenic and myogenic control in the rat portal vein. Acta Physiol Scand 94:112.Google Scholar
23.Miall, WE, Oldham, PD (1958): Factors influencing arterial blood pressure in the general population. Clin Sci 17:409.Google Scholar
24.Miall, WE, Kass, EH, Ling, J, et al (1962): Factors influencing arterial pressure in the general population in Jamaica. Brit Med J 2:497.CrossRefGoogle ScholarPubMed
25.Morton, NE, Gulbrandsen, CL, Rao, OC, et al (1980): Determinants of blood pressure in Japanese-American families. Am J Hum Genet 53:261.Google Scholar
26.Ostfeld, AM, Paul, O (1963): The inheritance of hypertension. Lancet i:575.CrossRefGoogle Scholar
27.Share, L, Crofton, JT, Rockhold, RW, et al (1982): Vasopressin secretion and responses to Captopril and a vasopressin antagonist in the Dahl rat. In: Rascher, W, Clough, D, Ganten, D (eds): Hypertensive Mechanisms: The Spontaneously Hypertensive Rat as a Model to Study Human Hypertension. Stuttgart: Schattauer, p 574.Google Scholar
28.Task Force on Blood Pressure Control in Children (1987): Report of the second task force on blood pressure control in children - 1987. Pediatrics 79:1.Google Scholar
29.Ward, RH, Chin, PG, Prio, IA (1980): Tokelau Island migrant study. Effect of migration on the familial organization of blood pressure. Hypertension 2 (Suppl I):43.Google Scholar
30.Welin, L, Svardsudd, K, Wilhelmsen, L, et al (1987): Analysis of risk factors for stroke in a cohort of men born in 1913. N Engl J Med 317:521.CrossRefGoogle Scholar
31.Wilson, TA, Kaiser, DL, Wright, EM Jr, et al (1981): Ontogeny of blood pressure and the renin-angiotensin-aldosterone system. Circ Res 49:416.Google Scholar
32.Zinner, SH, Levy, PS, Kass, EH (1971): Familial aggregation blood pressure in childhood. N Engl J Med 284:401.Google Scholar