No CrossRef data available.
Article contents
Biologic Effects of Recent Antimitotic Compounds: A comparative evaluation
Published online by Cambridge University Press: 01 August 2014
Summary
Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
An evaluation of the antimitotic activity of a group of antitumoral agents was performed. Their action was first assayed on chick embryo blood forming tissue, determining its survival, mitotic index and mitotic differential count: the statistically most active compounds were demecolcin, vinblastine and cyclophosphamide.
The same compounds were also tested on the in vitro blastic transformation of human leukocytes and their incorporation of tritiated DNA and RNA precursors.
The most active compounds in this assay was 5 fluorouracil; a lesser degree of inhibition was caused by vinblastine, cyclophosphamide and mechloretamine.
The effect of a single massive dose of the same compounds in vivo was also studied determining the in vitro activity of leukocytes of such patients, removed 48 hrs after the administration.
Preliminary results show that such leukocytes lose in variable degree their phyto-responsiveness in vitro.
- Type
- Research Article
- Information
- Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 1 , January 1968 , pp. 78 - 98
- Copyright
- Copyright © The International Society for Twin Studies 1967
References
Astaldi, G., Sauli, S. (1963). Ricerche sull'influenza del cortisone sulla trasformazione staminale dei linfociti per effetto della Fitoemagglutamina. Boll. Soc. Ital. Biol. Sper., 40: 329.Google Scholar
Astaldi, G., Sauli, S.
et al. (1966). Is the defective reaction to phytohaemagglutinin shown by the lymphocytes from lymphocytic leukemia depending on their innate structure or plasmatic characteristics?
Acta Med. Scandinav. Suppl., 445: 319.Google Scholar
Berneis, K.
et al. (1963). The degradation of deoxyribonucleic acid by new tumor inhibiting compounds: the intermediate formation of hydrogen peroxide. Experientia, 19: 132.Google Scholar
Bianchi, P.
et al. (1964). Deoxyribonucleic acid synthesis and thymidine phosphorylation in Ehrlich ascites tumor cells. In: Acidi nucleici e loro funzione biologica. Convegno A. Bosetti, 162; Milano.Google Scholar
Carrara, P. M., Eridani, S. (1958). A comparative study of the activity of some cytostatic agents on a biological test ‘in vivo’. Acta Haemat., 19: 289.Google Scholar
Cohen, S. S.
et al. (1958). The mode of action of 5-fluorouracil and its derivatives. Proc. Nat. Acad. Sci. USA, 44: 1004.CrossRefGoogle ScholarPubMed
Cooper, E. H.
et al. (1963). Observation on the proliferation of human leucocytes cultured with phytohaemagglutinin. Brit. J. Haemat., 9: 101.Google Scholar
Creasey, W. A., Markiw, M. E. (1964). Biochemical effects of the Vinca alkaloids. II. A comparison of the effect of Colchicine, Vinblastine and Vincristine on the synthesis of ribonucleic acids in Ehrlich ascites carcinoma cells. Biochem. Biophys. Acta, 87: 601.Google Scholar
Cronkite, E. P.
et al. (1962). Tritium-labelled thymidine (H3TDR): its somatic toxicity and use in the study of the growth rates and potentials in normal and malignant tissue of man and animals. In: Tritium in the Physical and Biological Science. Int.At.En.Ag., 2: 189. Gerin, Vienna.Google Scholar
Elves, M. W.
et al. (1964). The place of the lymphocyte in the reticulo-endothelial system: A study of the ‘in vitro’ effect of prednisolone on lymphocytes. Acta Haemat., 32: 100.Google Scholar
Eridani, S.
et al. (1961). Cytological effects of an antagonist of Vitamin B12
. Acta Haemat., 25: 35.CrossRefGoogle ScholarPubMed
Foley, G. E.
et al. (1958). A comparative study of the use of micro-organisms in the screening of potential antitumor agents. Ann. N. Y. Acad. Sci., 76: 413.Google Scholar
Hayhoe, F. G. I., Quaglino, D. (1965). Leukocytes cultured with phytohaemagglutinin: uridine-53H as a specific precursor of RNA. Nature, 205: 151.Google Scholar
Lawley, P. D. (1964). The action of alkylating agents on DNA in relation to biological effects of the alkylating agents. In: Acidi nucleici e loro funzione biologica. Convegno A. Bosetti, 25; Milano.Google Scholar
Osborn, M. J.
et al. (1958). Inhibition of dihydrofolic reductase by aminopterin and amethopterin. Proc. Soc. Exp. Biol. Med., 97: 429.CrossRefGoogle ScholarPubMed
Polli, E., Bianchi, P. A. (1965). Studi sulla sintesi del DNA nei leucociti normali e leucemici. Proc. Congr. Ital. Soc. Haemat., 73. E.M.E.S., Roma.Google Scholar
Polli, E., Bianchi, P. A.
et al. (1965). The role of corticosteroids in the treatment of myeloproliferative disorders and lymphoma. In: Hormonal Steroids, Biochemistry, Pharmacology and Therapeutics, 2: 367. Acad. Press, New York.Google Scholar
Rauen, H. M.
et al. (1964). Zum biochemischen Wirkungsmechanismus von Cyclophosphamid. Arzneimittelforschung, 3: 176.Google Scholar
Robbins, J. H. (1964). Human periferal blood in tissue culture and the action of phytohaemagglutinin. Experientia, 20: 164.Google Scholar
Rubini, J. R.
et al. (1962). In vitro metabolism of H3Thymidine. In: Tritium in the physical and biological science. Int. At. En. Ag., 2: 247. Gerin, Vienna.Google Scholar
Taglioretti, D.
et al. (1965). Metabolismo di leucociti normali e leucemici stimolati con fitoemagglutinina. Boll. Soc. hai. Emat., 13: 239.Google Scholar
Valentini, E.
et al. (1964). Studio sull'attività citostatica di alcuni recenti composti: Vinblastina, Vincristina, Daunomicina e Metilidrazina. Boll. Soc. Ital. Emat., 12: 3.Google Scholar
Villa, L.
et al. (1963). Azione della talidomide sull'attività mitotica di cellule ematiche embrionali. Ric. Sci., 23: 323.Google Scholar
You have
Access