The semiarid regions (SARs) are characterized by extreme temperature changes, low and unevenly distributed precipitation, hazardous torrential rains, and frequent early spring droughts. Barley is the most highly adapted cereal in SARs, but durum wheat is the most widely cultivated. The area in cereals varies considerably from year to year, and yields are low. Tillage practices are used to conserve both soil and moisture and to prepare the seed bed. However, improved fertilizer use and weed control practices are not being used. Without development of needed cultural and tillage practice systems, the genetic potential of today's varieties cannot be realized. Planting depth and rate, row spacing, fertilizer application, and weed control were investigated under conventional tillage and reduced tillage systems. In on-farm trials, reduced tillage did not significantly affect durum wheat yield but slightly increased barley yield compared with traditional practices. Optimum planting depth for both wheat and barley was 7 cm. Higher seeding rates increased the yield of both crops. Highest yields were obtained at planting rates of 140 kg/ha for wheat and 100 kg/ha for barley. At these rates, maximum yields were achieved at row spacings of 30 cm for barley and 20 cm for durum wheat. Use of fertilizer and weed control increased yields substantially. Sustained and increased production in SARs can be achieved with a “package of practices” approach that incorporates these cultural and tillage practices.