We have developed a technique to determine the dissolved solid components of water and other liquids by Energy- Dispersive X-Ray Fluorescence (EDXRF) spectrometry. The liquid samples are presented to the spectrometer as small dried spots of the residue remaining after evaporation of the liquid. The dried residues are mounted on thin plastic films cemented to 35 mm plastic slide mounts. Elements from sodium through uranium are detected with detection limits less than one nanogram in favorable cases. Precision of the measurement is better than 2 % relative in favorable cases for secondary-target excitation, and is typically 5 to 10 % for direct excitation given the geometry of the instrument. Detection limits are as low as a part per billion relative to the original liquid for solutions whose total dissolved solid content is 1000 part per million or less.