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Some Biomedical Applications of Charged-Particle-Induced X-Ray Fluorescence Analysis

Published online by Cambridge University Press:  06 March 2019

J. L. Campbell
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
A. W. Herman
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
L. A. McNelles
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
B. H. Orr
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
R. A. Willoughby
Affiliation:
University of Guelph, Guelph Ontario, N1G 2W1, Canada
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Abstract

X-ray fluorescence induced by charged particles has been employed in trace element analysis of both animal and human blood, tissue and bone samples. Preparation techniques included microtome slicing and wet digestion in nitric acid, internal chemical standards being used in the latter case.

Most of the specimens arose from a study of interactions between the toxic elements lead and zinc in growing foals; this was motivated by reports of sickness and death in foals raised near lead-zinc smelters. The cause of toxicity in animals from environmental pollution is often attributed to Single factors, whereas in reality interactions among many factors, including a variety of toxic and nutrient trace elements, should be considered.

A variety of spectra are presented and elemental concentrations derived. Agreement between the X-ray data and atomic absorption spectrophotometry is encouraging. The results demonstrate the potential of particle-excited X-ray fluorescenee as a broad-range analytical technique for the study of trace element interactions.

Type
Research Article
Copyright
Copyright © International Centre for Diffraction Data 1973

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References

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