Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-24T18:16:13.517Z Has data issue: false hasContentIssue false
  • English
  • Français

Feasibility Studies of X-ray Fluorescence as a Method for the In Vivo Determination of Platinum and Other Heavy Metals

Published online by Cambridge University Press:  06 March 2019

J. Dutton ,
C. J. Evans ,
S. B. Samat ,
W. D. Morgan  and
A. Sivyer
J. Dutton
Affiliation:
Department of Physics University College of Swansea Singleton Park, Swansea SA2 8PP, UK
C. J. Evans
Affiliation:
Department of Physics University College of Swansea Singleton Park, Swansea SA2 8PP, UK
S. B. Samat
Affiliation:
Department of Physics University College of Swansea Singleton Park, Swansea SA2 8PP, UK
W. D. Morgan
Affiliation:
Department of Medical Physics Singleton Hospital Swansea SA2 8QA, UK
A. Sivyer
Affiliation:
Department of Medical Physics Singleton Hospital Swansea SA2 8QA, UK
Get access

Extract

There has recently been growing interest in various atomic and nuclear techniques for the measurement of elements in the body. This has arisen through the realisation that (a) clinically-important amounts of toxic elements can be absorbed as a result of low-level environmental exposure, and (b) important information about the nutritional status of a patient can be obtained from measurements of major body elements. Where such information can be obtained by taking samples, a very wide range of analytical techniques is available, some capable of a sensitivity measured in parts-per-billion. Sampling is not possible, however, when the whole-body content (e.g. of nitrogen) is required, and is clinically undesirable when the element in question is concentrated in particular organs, for example as lead accumulates in the bones, and cadmium and many other toxic elements accumulate in the kidneys. It is in such cases that the various in vivo techniques are particularly important.

Type
V. Applications of XRF and XRD to Life Sciences and the Environment
Information
Advances in X-Ray Analysis , Volume 28: Thirty-Third Annual Conference on Applications of X-ray Analysis, July 30 - August 3, 1984 , 1984 , pp. 145 - 154
Copyright
Copyright © International Centre for Diffraction Data 1984

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ahlgren, L., Grönberg, T., and Mattsaon, S., 1980, In vivo x-ray fluorescence analysis for medical diagnosis, Adv. in x-ray anal., 23:185–191.Google Scholar
Ahlgren, L., Christofferson, J -O., Grönberg, T., and Mattsson, S., 1982, In vivo x-ray fluorescence analysis of lead cadmium and iodine in man, in: “X-ray fluorescence (XRF and PIXE) in medicine,” Field Educational Italia, Rome.Google Scholar
Aiginger, H., and Wobrauschek, P., 1980, X-ray fluorescence analysis in the nanogram region with a Bragg polarised primary beam, in: “Trace element analytical chemistry in medicine and biology,” De Gruyter, Berlin and New York.Google Scholar
Bloch, P., Mack, O., Glover, I., Goodman, R. L., Goodman, I. E., and Shapiro, I. E., 1983, An x-ray fluorescence, XRF, technique to assay Pt in urine samples from patients receiving cis-platinum, Med. Phys., 10:517.Google Scholar
Manaka, R. C., and Wolf, W., 1980, Radiopharmacokinetics of cisplatin, in: “Cisplatin current status and new developments”, Academic Press, London and New York.Google Scholar
Morgan, W. D., Dutton, J., Sivyer, A., Evans, C. J., Samat, S. B., and Kyde, S. J., 1985, The role of in vivo analytical techniques in the assessment of environmental exposure to heavy metals, in: 4th International Conference on Heavy Metals in the Environment, Heidelberg, CEP Consultants Ltd., Edinburgh.Google Scholar
Wielopolski, L., Slatkin, D. K., Vartsky, D., Ellis, K. J., and Cohn, S. H., 1981, Feasibility study for the in vivo measurement of lead in bone using L - x -ray fluorescence, IEEE Trans, on Nucl. Sci., US - 28: 114–116.Google Scholar
World Health Organisation, 1977, Use of ionising radiation and radionuclides on human beings for medical research, training, and non medical purposes, Technical report series 611, Geneva.Google Scholar