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Dementia with Lewy bodies

Published online by Cambridge University Press:  02 January 2018

E. Jane Byrne
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Dementia with cortical Lewy bodies (LBD) was first described by Okazaki et al in 1961 and is now recognised as a relatively common cause of the dementia syndrome. The true prevalence of LBD is unknown. In post-mortem studies of patients diagnosed as having dementia in life, the mean frequency of Lewy body dementia is 12.5% (Byrne, 1997). Clinically diagnosed LBD (using operational clinical criteria) is found in 10–23% of patients presenting to, or in the care of, psychogeriatric services (Collerton et al, 1996). What is not yet certain is its nosological status; opinion is divided between regarding it as a variety of Alzheimer's disease (the Lewy body variant), a distinct disease (senile dementia of the Lewy body type) or a spectrum disorder related to both Parkinson's disease and to Alzheimer's disease (Byrne, 1992).

Type
Research Article
Information
Advances in Psychiatric Treatment , Volume 4 , Issue 6 , November 1998 , pp. 360 - 363
Copyright
Copyright © The Royal College of Psychiatrists 1998 

References

Armstrong, M., Daly, A. K., Cholerton, S. et al (1992) Mutant debrisoquine hydroxylation genes in Parkinson's disease. Lancet, 399, 1017–1018.Google Scholar
Broe, G. & Caird, F. I. (1973) Levadopa for Parkinsonism in elderly and demented patients. Medical Journal of Australia, 1, 630–635.Google Scholar
Byrne, E. J. (1992) Diffuse Lewy body disease: Disease, spectrum disorder or variety of Alzheimer's disease. International Journal of Geriatric Psychiatry, 7, 229–234.Google Scholar
Byrne, E. J. (1996) The nature of the cognitive decline in Lewy body dementia. In Dementia with Lewy Bodies (eds Perry, R., McKeith, I. & Perry, E.) pp. 57–66. Cambridge: Cambridge University Press.Google Scholar
Byrne, E. J. (1997) Lewy body dementia. Journal of the Royal Society of Medicine, 90 (suppl. 32), 14–15.Google Scholar
Cockrell, J. R. & Folstein, M. F. (1988) Mini mental state examination (MMSE). Pharmacology Bulletin, 24, 689–692.Google ScholarPubMed
Collerton, D., Davies, C. & Thompson, P. (1996) Lewy body dementia in clinical practice. In Dementia with Lewy Bodies (eds Perry, R., McKeith, I. & Perry, E.) pp. 171–186. Cambridge: Cambridge University Press.Google Scholar
Crystal, H. A., Dickson, D. W., Lixarni, J. E. et al (1990) Antemortem diagnosis of diffuse Lewy body disease. Neurology, 40, 1523–1528.Google Scholar
Denson, M. A., Wszolek, Z. K., Pfeipfer, R. F. et al (1997) Familial parkinsonism, dementia and Lewy body disease: Study of familial G. Annals of Neurology, 42, 638–643.Google Scholar
Dickson, D. W., Crystal, H. P., Davies, P. et al (1996) Cytoskel and Alzheimer-type pathology in Lewy body disease. In Dementia with Lewy Bodies (eds Perry, R., McKeith, I. & Perry, E.) pp. 224–237. Cambridge: Cambridge University Press.Google Scholar
Förstl, H., Burns, A., Luthert, P. et al (1993) The Lewy-body variant of Alzehimer's disease. Clinical and pathological findings. British Journal of Psychiatry, 162, 385–392.Google Scholar
Galasko, D., Hansen, L. A., Katzman, R. et al (1994) Clinical neuropathological correlations in Alzehimer's disease and related dementia. Archives of Neurology, 51, 888–895.Google Scholar
Gnanalingham, K. K., Byrne, E. J., Thornton, A. et al (1997) Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases. Journal of Neurology, Neurosurgery and Psychiatry, 62, 243–252.Google Scholar
Hansen, L., Salmon, D., Galasko, D. et al (1990) The Lewy body variant of Alzheimer's disease: A clinical and pathological entity. Neurology, 40, 1–8.Google Scholar
Lennox, G. (1992) Lewy body dementia. Baillières Clinical Neurology, 1, 653–676.Google Scholar
Lipowski, Z. J. (1990) Delirium: Acute confusional states. Oxford: Oxford University Press.Google Scholar
Louis, E. D., Goldman, J. E., Powers, J. M. et al (1995) Parkinsonian features of eight pathological diagnosed cases of diffuse Lewy body disease. Movement Disorders, 10, 188–194.Google Scholar
Mattis, S. (1976) Mental status examination for organic mental syndrome in the elderly patient. In Geriatric Psychiatry (eds Bellack, R. & Karasie, ) pp. 77–121. New York: Grune & Stratton.Google Scholar
McKeith, I. G., Fairbairn, A. F., Perry, R. H. et al (1992). Neuroleptic sensitivity in patients with senile dementia of Lewy body type. British Medical Journal, 305, 673–678.Google Scholar
McKeith, I. G., Galasko, D., Kosaka, K. et al (1996) Clinical and pathological diagnosis of dementia with Lewy bodies: report of the CLBD international workshop. Neurology, 47, 1113–1124.Google Scholar
Okasaki, H., Lipkin, L. E. & Aronson, S. M. (1961) diffuse intracytoplasmic ganglionic inclusions (Lewy type) associated with progressive dementia and quadriparesis in flexion. Journal of Neuropathology and Experimental Neurology, 20, 287–291.Google Scholar
Perry, E. K., Marshall, E., Kerwin, J. et al (1990a) Evidence of a monoaminergic-cholinergic imbalance related to visual hallucinations in Lewy body type dementia. Journal of Neurochemistry, 55, 1454–1456.Google Scholar
Perry, E. K. & Perry, R. H. (1996) Altered consciousness and transmitter signalling in Lewy body dementia. In Dementia with Lewy Bodies (eds Perry, R., McKeith, I. & Perry, E.) pp. 397–413. Cambridge: Cambridge University Press.Google Scholar
Perry, R. H., Irving, D., Blessed, G. et al (1990b) Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly. Journal of Neurological Sciences, 95, 119–139.Google Scholar
Saitoh, T., Xia, Y., Chen, X. et al (1995) The CYP2D6B mutant allele is overrepresented in the Lewy body bariant of Alzehimer's disease. Annals of Neurology, 37, 110–112.Google Scholar
Saitoh, T. & Katzman, R. (1996) Genetic correlations in Lewy body disease. In Dementia with Lewy Bodies (eds Perry, R., McKeith, I. & Perry, E.) pp. 336–349. Cambridge: Cambridge University Press.Google Scholar
Salman, D. P. & Galasko, D. (1996). Neuropsyhological aspects of Lewy body dementia. In Dementia with Lewy Bodies (eds Perry, R., McKeith, I. & Perry, E.) pp. 99–113. Cambridge: Cambridge University Press.Google Scholar
Williams, S. W., Byrne, E. J. & Stokes, P. (1993) The treatment of diffuse Lewy body disease: A pilot study of five cases. International Journal of Geriatric Psychiatry, 8, 731–739.Google Scholar
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