Skip to main content Accessibility help
×
Home

CADASIL: a guide to a comparatively unrecognised condition in psychiatry

  • Mark H. Taylor and Gillian A. Doody

Abstract

This guide to the neurological disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leuco encephalopathy (CADASIL) is specifically targeted at psychiatrists. The aims are to enhance awareness, provide educational clinical information and offer practical guidance on management of the disorder. An overview of diagnostic algorithms and recent research is also provided.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      CADASIL: a guide to a comparatively unrecognised condition in psychiatry
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      CADASIL: a guide to a comparatively unrecognised condition in psychiatry
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      CADASIL: a guide to a comparatively unrecognised condition in psychiatry
      Available formats
      ×

Copyright

References

Hide All
Alexopoulos, G. S., Meyers, B. S., Young, R. C. et al (1997) ‘Vascular depression’ hypothesis. Archives of General Psychiatry, 54, 915922.
Committee on Safety of Medicines (2004) Atypical Antipsychotic Drugs and Stroke: 9 March 2004. Medicines and Healthcare products Regulatory Agency (http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safetywarningsandmessagesformedicines/CON1004298).
Davies, S. J. C., Jackson, P. R., Potokar, J. et al (2004) Treatment of anxiety and depressive disorders in patients with cardiovascular disease. BMJ, 328, 939943.
Davous, P. (1998) CADASIL: a review with proposed diagnostic criteria. European Journal of Neurology, 5, 219233.
Desmond, D. W., Moroney, J. T., Lynch, T. et al (1999) The natural history of CADASIL: a pooled analysis of previously published cases. Stroke, 30, 12301233.
Dichgans, M., Mayer, M., Uttner, I. et al (1998) The phenotypic spectrum of CADASIL: clinical findings in 102 cases. Annals of Neurology, 44, 731739.
Dichgans, M., Markus, H. S. et al (2008) Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. Lancet Neurology, 7, 310318.
Faculty for the Psychiatry of Old Age (2006) Atypical Antipyschotics and Behavioural and Psychiatric Symptoms of Dementia: Prescribing Update for Old Age Psychiatrists. Royal College of Psychiatrists (http://www.rcpsych.ac.uk/PDF/BPSD.pdf).
Holtmannspotter, M., Peters, N., Opherk, C. et al (2005) Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two year follow-up study. Stroke, 36, 25592565.
Joutel, A., Vahedi, K., Corpechot, C. et al (1997) Strong clustering and stereotyped nature of notch3 mutations in CADASIL patients. Lancet, 350, 15111515.
Kalaria, R. N., Viitanen, M., Kalimo, H. et al (2004) The pathogenesis of CADASIL: an update. Journal of Neurological Sciences, 226, 3539.
Kennedy, G. J. & Marcus, P. (2005) Use of antidepressants in older patients with co-morbid medical conditions: guidance from studies of depression in somatic illness. Drugs and Aging, 22, 273287.
Kessing, L. V. (2005) Severe brain pathology: underdiagnosed in psychiatric patients? (Invited comment). Acta Psychiatrica Scandinavica, 111, 396397.
Keverne, J. S., Low, W. C., Ziabreva, I. et al (2006) Cholinergic neuronal deficits in CADASIL. Stroke, 38, 188191.
Kumar, P. & Clark, M. (2005) Clinical Medicine (6th edn). Elsevier.
Lagas, P. A. & Juvonen, V. (2001) Schizophrenia in a patient with cerebral autosomally dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL disease). Nordic Journal of Psychiatry, 55, 4142.
Leyhe, T., Wiendl, H., Buchkremer, G. et al (2005) CADASIL: underdiagnosed in psychiatric patients? Acta Psychiatrica Scandinavica, 111, 392396.
Markus, H. S., Martin, R. J., Simpson, M. A. et al (2002) Diagnostic strategies in CADASIL. Neurology, 59, 11341138.
Mesulam, M., Siddique, T. & Cohen, B. (2003) Cholinergic denervation in a pure multi-infarct state. Neurology, 60, 11831185.
National Collaborating Centre for Mental Health (2006) Dementia: Supporting People with Dementia and Their Carers in Health and Social Care (NICE Clinical Guideline 42). National Institute for Health and Clinical Excellence.
Opherk, C., Peters, N., Holtmannspotter, M. et al (2006), Heritability of MRI lesion volume in CADASIL: evidence for genetic modifiers. Stroke, 37, 26842689.
O'Sullivan, M., Jarosz, J. M., Martin, R. J. et al (2001) MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology, 56, 628634.
Pantoni, L., Pescini, F., Inzitari, D. et al (2005) Postpartum psychiatric disturbances as an unrecognised onset of CADASIL. Acta Psychiatrica Scandinavica, 112, 241.
Razvi, S. S. M., Davidson, R., Bone, I. et al (2005) The prevalence of CADASIL in the West of Scotland. Journal of Neurology, Neurosurgery and Psychiatry, 76, 739741.
Schon, F., Martin, R. J., Prevett, M. et al (2003) ‘CADASIL coma’: an underdiagnosed acute encephalopathy. Journal of Neurology, Neurosurgery and Psychiatry, 74, 249252.
Singhal, S., Bevan, S., Barrick, T. et al (2004) The influence of genetic and cardiovascular risk factors on the CADASIL phenotype. Brain, 127, 20312038.
Singhal, S., Rich, P. & Markus, H. S. (2005) The spatial distribution of MR imaging abnormalities in CADASIL and their relationship to age and clinical features. American Journal of Neuroradiology, 26, 24812487.
Spalletta, G., Bossa, P., Ciaramella, A. et al (2006) The aetiology of post-stroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines. Molecular Psychiatry, 11, 984991.
Taylor, D., Paton, C. & Kerwin, R. (2007) Maudsley Prescribing Guidelines (9th edn). Informa Healthcare.
Verin, M., Rolland, Y., Landgraf, F. et al (1995) New phenotype of the cerebral autosomal dominant arteriopathy mapped to chromosome 19: migraine as the prominent clinical feature. Journal of Neurology, Neurosurgery and Psychiatry, 59, 579585.
Viswanathan, A., Guichard, J. P., Gschwendtner, A. et al (2006) Blood pressure and haemoglobin A1c are associated with microhaemorrhage in CADASIL: a two-centre cohort study. Brain, 129, 23752383.
Waldemar, G., Dubois, B., Emre, M. et al (2007) Recommendations for the diagnosis and management of Alzheimer's and other disorders associated with dementia: EFNS (European Federation of Neurological Science) guideline. European Journal of Neurology, 14, e1e26.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

CADASIL: a guide to a comparatively unrecognised condition in psychiatry

  • Mark H. Taylor and Gillian A. Doody
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *