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Serum levels of carcinoembryonic antigen (CEA) in patients with bipolar disorder

  • Ibrahim Kaplan (a1), Mahmut Bulut (a2), Abdullah Atli (a2), Mehmet Güneş (a2), Mehmet Cemal Kaya (a2) and Leyla Çolpan (a1)...

Abstract

Objective

Carcinoembryonic antigen (CEA) is an oncofetal glycoprotein that is widely used as a tumour marker in adenocarcinomas. However, several non-neoplastic conditions, including acute and chronic inflammation and other inflammation-related conditions, are characterised by increased CEA concentrations.

Bipolar disorder (BD) ranks seventh among the worldwide burden of non-fatal diseases. Inflammatory biomarkers have been considered as one of the main key pillars of a multifactorial approach for prediction of BD in an at-risk population.

BP is accompanied by activation of inflammatory, cell-mediated and negative immunoregulatory cytokines.

Methods

We measured the levels of CEA in serum samples from 44 individuals with euthymic BP out-patients and 45 healthy controls. Patients were diagnosed according to the DSM-IV criteria. CEA was measured by an electrochemiluminescence immunoassay.

Results

The mean serum CEA concentration was 2.36±1.52 and 1.77±0.98 µg/l in patients and controls, respectively. CEA levels were significantly increased in euthymic BP patients when compared with controls (p=0.031).

Conclusions

This study suggests that CEA is increased in BD and supports a role for immune activation in the core pathological mechanisms of BP. CEA levels may be a secondary marker for diagnosing BP.

Copyright

Corresponding author

Ibrahim Kaplan, Department of Medical Biochemistry, Medical Faculty, Dicle University, Diyarbakır, Turkey. Tel: +90 505 451 2025; Fax: +90 412 248 8520; E-mail: dribrahimkaplan@hotmail.com

References

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Keywords

Serum levels of carcinoembryonic antigen (CEA) in patients with bipolar disorder

  • Ibrahim Kaplan (a1), Mahmut Bulut (a2), Abdullah Atli (a2), Mehmet Güneş (a2), Mehmet Cemal Kaya (a2) and Leyla Çolpan (a1)...

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