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Plasma glial cell line-derived neurotrophic factor in patients with major depressive disorder: a preliminary study

Published online by Cambridge University Press:  30 June 2015

Bun-Hee Lee ,
Jin-Pyo Hong ,
Jung-A Hwang ,
Kyoung-Sae Na ,
Won-Joong Kim ,
Jose Trigo  and
Yong-Ku Kim
Bun-Hee Lee
Affiliation:
Department of Psychiatry, Seoul Eunpyeong Hospital, Seoul, Republic of Korea
Jin-Pyo Hong
Affiliation:
Department of Psychiatry, Samsung Medical Center, Seoul, Republic of Korea
Jung-A Hwang
Affiliation:
Department of Psychiatry, Korea University Ansan Hospital, Kyunggi, Republic of Korea
Kyoung-Sae Na
Affiliation:
Department of Psychiatry, Gacheon University Gil Medical Center, Incheon, Republic of Korea
Won-Joong Kim
Affiliation:
Translational Addiction Research Laboratory, Center for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada Department of Health Science, McMaster University, Hamilton, Ontario, Canada
Jose Trigo
Affiliation:
Translational Addiction Research Laboratory, Center for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada
Yong-Ku Kim*
Affiliation:
Department of Psychiatry, Korea University Ansan Hospital, Kyunggi, Republic of Korea
*
Professor Yong-Ku Kim, Department of Psychiatry, Korea University Ansan Hospital, Gojan-dong, Ansan, Kyunggi, Republic of Korea.Tel: +82 31 412 5140; Fax: +82 31 412 5144; E-mail: yongku@korea.ac.kr
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Abstract

Background

Some clinical studies have reported reduced peripheral glial cell line-derived neurotrophic factor (GDNF) level in elderly patients with major depressive disorder (MDD). We verified whether a reduction in plasma GDNF level was associated with MDD.

Method

Plasma GDNF level was measured in 23 healthy control subjects and 23 MDD patients before and after 6 weeks of treatment.

Results

Plasma GDNF level in MDD patients at baseline did not differ from that in healthy controls. Plasma GDNF in MDD patients did not differ significantly from baseline to the end of treatment. GDNF level was significantly lower in recurrent-episode MDD patients than in first-episode patients before and after treatment.

Conclusions

Our findings revealed significantly lower plasma GDNF level in recurrent-episode MDD patients, although plasma GDNF levels in MDD patients and healthy controls did not differ significantly. The discrepancy between our study and previous studies might arise from differences in the recurrence of depression or the ages of the MDD patients.

Keywords

affective disorderglial cell line-derived neurotrophic factormajor depressive disorderprotein analysis
Type
Short Communications
Information
Acta Neuropsychiatrica , Volume 28 , Issue 1 , February 2016 , pp. 45 - 50
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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