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Pharmacotherapy for co-occurring alcohol and drug disorders in schizophrenia and bipolar disorder: where is the evidence?

  • Dan I. Lubman (a1) and Michael Berk (a1)


Corresponding author

Associate Professor Dan I. Lubman, Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, 35 Poplar Rd (Locked Bag 10), Parkville, Victoria 3052, Australia. Tel: 61 3 9342 2888; Fax: 61 3 9342 2941; E-mail:


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1.Regier, DA, Farmer, ME, Rae, DSet al. Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiological Catchment Area (ECA) study. JAMA 1990;264:25112518.
2.Lubman, DI, Sundram, S.Substance misuse in patients with schizophrenia: a primary care guide. Med J Aust 2003;178:S71S75.
3.Green, AI, Noordsy, DL, Brunette, MF, O’Keefe, C.Substance abuse and schizophrenia: pharmacotherapeutic intervention. J Subst Abuse Treat 2008;34:6171.
4.Lambert, M, Conus, P, Lubman, DIet al. The impact of substance use disorders on clinical outcome in 643 patients with first-episode psychosis. Acta Psychiatr Scand 2005;112:141148.
5.Kemp, DE, Gao, K, Ganocy, SJ, Elhaj, O, Bilali, SR, Conroy, C, Findling, RL, Calabrese, JR.A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and co-occurring substance abuse or dependence. J Clin Psychiatry 2009;70:113121.
6.Mathias, S, Lubman, DI, Hides, L.Substance-induced psychosis: a diagnostic conundrum. J Clin Psychiatry 2008;69:358367.
7.San, L, Arranz, B, Martinez-Raga, J.Antipsychotic drug treatment of schizophrenic patients with substance abuse disorders. Eur Addict Res 2007;13:230243.
8.Baker, A, Hides, L, Lubman, DI.Treatment of cannabis use among people with psychotic and depressive disorders: a systematic review. J Clin Psychiatry 2010 (in press).
9.Rubio, G, Martinez, I, Ponce, G, Jimenez-Arriero, MA, Lopez-Munoz, F, Alamo, C.Long-acting injectable risperidone compared with zuclopenthixol in the treatment of schizophrenia with substance abuse comorbidity. Can J Psychiatry 2006;51:531539.
10.Brown, ES, Garza, M, Carmody, TJ.A randomized, double-blind, placebo-controlled add-on trial of quetiapine in outpatients with bipolar disorder and alcohol use disorders. J Clin Psychiatry 2008;69:701705.
11.Nejtek, VA, Avila, M, Chen, LAet al. Do atypical antipsychotics effectively treat co-occurring bipolar disorder and stimulant dependence? A randomized, double-blind trial. J Clin Psychiatry 2008;69:12571266.
12.Salloum, IM, Cornelius, JR, Daley, DC, Kirisci, L, Himmelhoch, JM, Thase, ME.Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study. Arch Gen Psychiatry 2005;62:3745.
13.Petrakis, IL, Nich, C, Ralevski, E.Psychotic spectrum disorders and alcohol abuse: a review of pharmacotherapeutic strategies and a report on the effectiveness of naltrexone and disulfiram. Schizophr Bull 2006;32:644654.
14.Drake, RE, O’Neal, EL, Wallach, MA.A systematic review of psychosocial research on psychosocial interventions for people with co-occurring severe mental and substance use disorders. J Subst Abuse Treat 2008;34:123138.
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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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