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No borna disease virus-specific RNA detected in blood of race horses and jockeys

  • Yong-Ku Kim (a1), Kyung-Bo Noh (a2), Chang-Su Han (a1), Ju-Young Moon (a2), Do-Kyung Yoon (a3), Ki-Joon Song (a2), Dai-Jin Kim (a4), Marta Kubera (a5), Michael Maes (a6) and Jin-Won Song (a2)...

Abstract

Background:

Borna disease virus (BDV) predominantly infects horses and sheep, causing a broad range of behavioural disorders. It is controversial whether BDV infects humans and causes psychiatric disorders.

Objectives:

We searched for BDV-derived nucleic acids in blood of race horses and jockeys riding the horses.

Methods:

We assayed for the BDV genome in RNA extracted from peripheral blood mononuclear cells (PBMC) of 39 race horses and 48 jockeys. Two polymerase chain reaction protocols [one-tube reverse transcription–polymerase chain reaction (RT-PCR) and two-step RT-PCR] were used to assay BDV p24 and p40 transcripts.

Results:

The p24 and p40 viral nucleic acid sequences were not detected in the PBMC RNAs from any of the race horses or jockeys.

Conclusions:

These data do not support an epidemiological association between BDV infection, race horses and humans.

Copyright

Corresponding author

Professor Yong-Ku Kim, Department of Psychiatry, Korea University Ansan Hospital, 516, Gojan Dong, Danwon Gu, Ansan city, Kyunggi Province 425-020, South Korea. Tel: +82 31 412 5140; Fax: +82 31 412 5144; E-mail: yongku@korea.ac.kr

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