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Involvement of NLRP3 inflammasome in schizophrenia-like behaviour in young animals after maternal immune activation

Published online by Cambridge University Press:  14 July 2020

Letícia Ventura ,
Viviane Freiberger ,
Vinicius B. Thiesen ,
Paula Dias ,
Matheus L. Dutra ,
Bruna B. Silva ,
Aline D. Schlindwein  and
Clarissa M. Comim Open the ORCID record for Clarissa M. Comim [Opens in a new window]
Letícia Ventura
Affiliation:
Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270Palhoça, SC, Brazil
Viviane Freiberger
Affiliation:
Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270Palhoça, SC, Brazil
Vinicius B. Thiesen
Affiliation:
Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270Palhoça, SC, Brazil
Paula Dias
Affiliation:
Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270Palhoça, SC, Brazil
Matheus L. Dutra
Affiliation:
Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270Palhoça, SC, Brazil
Bruna B. Silva
Affiliation:
Research Group on Allergy, Inflammation and Infectious Disease, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270Palhoça, SC, Brazil
Aline D. Schlindwein
Affiliation:
Research Group on Allergy, Inflammation and Infectious Disease, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270Palhoça, SC, Brazil
Clarissa M. Comim*
Affiliation:
Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270Palhoça, SC, Brazil
*
Author for correspondence: Clarissa M. Comim, Email: clarissa.comim@unisul.br
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Abstract

Objective:

To evaluate the involvement of nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome in schizophrenia-like behaviour in young animals exposed to maternal immune activation (MIA).

Methods:

To this aim, on the 15th gestational day, the females received an injection of lipopolysaccharides. When the animals completed 7, 14 and 45 postnatal days, they were killed and the whole brain was dissected for biochemical analysis. Animals with 45 postnatal days were submitted to behavioural tests of locomotor activity, social interaction and stereotyped movements.

Results:

It was observed that the animals presented schizophrenia-like behaviour at 45 postnatal days associated with the increase of NLRP3 inflammasome expression and IL-1β levels on 7, 14 and 45 postnatal days.

Conclusion:

This study shows that MIA may be associated with a schizophrenia-like behaviour. This behaviour can be induced to a neuroinflammatory profile in the brain. These evidences may base future studies on the relationship between neuroinflammation and psychiatric disorders.

Keywords

maternal immune activationNLRP3 inflammasomeIL-1β levelsschizophrenia-like behaviour
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 32 , Issue 6 , December 2020 , pp. 321 - 327
Copyright
© Scandinavian College of Neuropsychopharmacology 2020

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