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Incident psychopharmacological treatment and psychiatric hospital contact in individuals with newly developed type 2 diabetes – a register-based cohort study

Published online by Cambridge University Press:  28 October 2020

Christopher Rohde ,
Norbert Schmitz ,
Reimar W. Thomsen  and
Søren D. Østergaard Open the ORCID record for Søren D. Østergaard [Opens in a new window]
Christopher Rohde*
Affiliation:
Department of Affective Disorders, Aarhus University Hospital – Psychiatry, Aarhus, Denmark Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Norbert Schmitz
Affiliation:
Department of Psychiatry, McGill University, Montreal, Canada Douglas Research Centre, McGill University, Montreal, Canada Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada Montreal Diabetes Research Centre, Montreal, Canada
Reimar W. Thomsen
Affiliation:
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
Søren D. Østergaard
Affiliation:
Department of Affective Disorders, Aarhus University Hospital – Psychiatry, Aarhus, Denmark Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
*
Author for correspondence: Christopher Rohde, Email: CHRROH@rm.dk
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Abstract

To investigate the association between newly developed type 2 diabetes (T2D) and incident psychopharmacological treatment and psychiatric hospital contact. Via Danish registers, we identified all 56 640 individuals from the Central and Northern Denmark Regions with newly developed T2D (defined by the first HbA1c measurement ≥6.5%) in 2000–2016 as well as 315 694 age- and sex-matched controls (without T2D). Those having received psychopharmacological treatment or having had a psychiatric hospital contact in the 5 years prior to the onset of T2D were not included. For this cohort, we first assessed the 2-year incidence of psychopharmacological treatment and psychiatric hospital contact. Secondly, via Cox regression, we compared the incidence of psychopharmacological treatment/psychiatric hospital contact among individuals with T2D to propensity score-matched controls – taking a wide range of potential confounders into account. Finally, via Cox proportional hazards regression, we assessed which baseline (T2D onset) characteristics were associated with subsequent psychopharmacological treatment and psychiatric hospital contact. A total of 8.3% of the individuals with T2D initiated psychopharmacological treatment compared to 4.6% of the age- and sex-matched controls. Individuals with T2D were at increased risk of initiating psychopharmacological treatment compared to the propensity score-matched controls (HR = 1.51, 95% CI = 1.43–1.59), whereas their risk of psychiatric hospital contact was not increased to the same extent (HR = 1.14, 95% CI = 0.98–1.32). Older age, somatic comorbidity, and being divorced/widowed were associated with both psychopharmacological treatment and psychiatric hospital contact following T2D. Individuals with T2D are at elevated risk of requiring psychopharmacological treatment.

Keywords

diabetes mellitustype 2mental disorderspsychotropic drugspsychiatryhospitalspsychiatric
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 33 , Issue 2 , April 2021 , pp. 72 - 84
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Copyright
© Scandinavian College of Neuropsychopharmacology 2020

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